Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"virulence factor production"”.
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Impaired virulence factor production in a dihydroorotate dehydrogenase mutant (pyrD) of Pseudomonas aeruginosa.
… for pyrimidines but they were also impaired in virulence factor production. Such a correlation had not been previously reported for P. aeruginosa, a ubiquitous opportunistic pathogen in humans. In an earlier study it was reported that mutants blocked in one of the first three enzymes of the …
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Isolation of a Pseudomonas aeruginosa Aspartate Transcarbamoylase Mutant and the Investigation of Its Growth Characteristics, Pyrimidine Biosynthetic Enzyme Activities, and Virulence Factor Production
… pyrimidines and decreased ability to produce virulence factors. In this work an organism with a mutation in the second step of the pathway, aspartate transcarbamoylase (ATCase), was created. Assays for pyrimidine intermediates, and virulence factors were performed. Results showed that the …
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The influence of non-inhibitory concentrations of purified pyocin S2 on Pseudomonas aeruginosa isolates
… isolate using S-type pyocins to decrease the virulence of other isolates in a Drosophila melanogaster model. We have reason to believe that this decrease in virulence may not only be because of the direct inhibition of the target isolates but additionally from a reduction in their virulence …
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Pyrimidine Enzyme Specific Activity at Four Different Phases of Growth in Minimal and Rich Media, and Concomitant Virulence Factors Evaluation in Pseudomonas aeruginosa
… mortality in immunocompromised patients, given virulence factor production that suppresses antibiotic therapy and promotes persistent infection. This research is the first comprehensive report of the pyrimidine biosynthetic pathway for all phases of growth in minimal and rich media coupled with …
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Studying the Competence Regulon Quorum Sensing Circuity in Streptococcus mitis
… density and initiate the group behaviors such as virulence factor production, biofilm formation, and competence development bacteria rely on the production and release of signaling molecules into their environment. QS could thus be utilized as a potential non-antibiotic therapeutic strategy to …
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The synthesis and biological evaluation of a library of autoinducer-antibiotic conjugates
… and are involved in the control of swarming, virulence factor production and biofilm formation. The quorum sensing molecules produced by \textit{Pseudomonas aeruginosa} were chosen for investigation as \textit{P. aeruginosa} is a significant human pathogen which displays high resistance to …
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Nutritional modeling of bacterial infections : physiology and metabolism of Pseudomonas aeruginosa during growth in cystic fibrosis sputum
… medium. P. aeruginosa also demonstrates enhanced production of the cell-cell communication signal 2-heptyl-3-hydroxy-4-quinolone (the Pseudomonas quinolone signal, PQS), a critical regulator of virulence factor production, during growth in CF sputum. Further, I use chemical analyses of CF sputum …
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Evolution and Regulation of Virulence and Antimicrobial Resistance in Pseudomonas aeruginosa
… life-threatening infections. There are several factors that make P. aeruginosa a successful pathogen, including its metabolic versatility, its propensity to acquire antimicrobial resistance (AMR) and the ability to produce numerous virulence factors. However, the expression of virulence factors …
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I. Stereochemical Control of Chiral Assembly and Liquid Crystal Phase Formation of Nonamphiphilic Molecules in Water II. Control Bacterial Quorum Sensing and Quorum Sensing-mediated Activities Using Small Unnatural Molecules
… activities such as biofilm formation and virulence factor production, which were key factors in the pathogenicity of the bacteria. These compounds exhibited significant reduction in the toxicity of human neuroblastoma SK-N-SH and did not inhibit bacterial growth. Furthermore, one compound, …
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Catalase, superoxide dismutase, and hemolysin in the virulence of Listeria monocytogenes
… into ten-day-old chick embryos to relate virulence factor production with pathogenicity. The hemolytic strain gave an LD$\sb{50}$ less than a single cell when grown in many of the aforementioned media while the nonhemolytic strain exhibited a higher LD$\sb{50}$ when propagated in TSBW …
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Interaction of skin cells with skin microbiota
… NCTC 11047 supernatant on the biofilm formation, virulence factors production, and quorum sensing network of P. aeruginosa strains NCTC 10662 and PAO1 was investigated using a range of colorimetric assays and RT-qPCR. Also, the effect of S. epidermidis supernatant on the viability, migration, and …
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Comprehensive Investigation into the Molecular Mechanisms Driving the Emergence of emm4 Group A Streptococcus
… to augmented infection severity due to increased virulence factor production. Recently, we characterized a clonal emergence, expansion, and replacement involving <em>emm4 </em>GAS<em> </em>strains in the United States and the United Kingdom. Using strains collected as part of active surveillance, …
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Novel small molecules for modulation of bacterial signaling pathways
… to express various pathogenic traits such as virulence factor production and biofilm formation. Therefore, QS inhibition is a promising novel strategy to selectively control multidrug-resistant pathogenic bacteria, without exerting evolutionary pressures and development of resistance. This …