Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 149 for “"virulence factor"”.
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Mycobacterium Tuberculosis Virulence Factor Mpt64 Targets the Endoplasmic Reticulum
… of time. Many intracellular pathogens secret virulence factors targeting host membranes and organelles to remodel their intracellular environmental niche. I hypothesized that M. tuberculosis secreted proteins that target host membranes are vital for M. tuberculosis to adapt to and manipulate …
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The Convergence of Metabolism and Virulence Factor Regulation on Streptococcus pyogenes Pathogenesis
… of metabolism with the expression of virulence factors is necessary for colonization. Previous research examining the regulation of virulence factors in <italic>S. pyogenes</italic> identified a unique catabolite sensing regulatory pathway composed of the tagatose bis-phosphate …
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Impaired virulence factor production in a dihydroorotate dehydrogenase mutant (pyrD) of Pseudomonas aeruginosa.
… for pyrimidines but they were also impaired in virulence factor production. Such a correlation had not been previously reported for P. aeruginosa, a ubiquitous opportunistic pathogen in humans. In an earlier study it was reported that mutants blocked in one of the first three enzymes of the …
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Evaluating protein-protein interactions of CpsA, a virulence factor in Group B Streptococcus
… sepsis and meningitis in newborns. The virulence of GBS in part can be attributed to its ability to produce a polysaccharide capsule. CpsA has been recognized as an integral part of capsule synthesis as well as having a role in transcriptional regulation. We hypothesize that …
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Functional and Structural Characterisation of Spy0136, a Novel Group A Streptococcal Virulence Factor
… all over the world. GAS generates numerous virulence factors contributing to the bacteria's pathogenesis. However, the function of many of these factors has yet to be identified, and more studies to gain a better understanding of host and bacterial factors are required for developing …
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An investigation of Porphyromonas gingivalis peptidylarginine deiminase: a putative virulence factor in an animal model of inflammation.
… the influence of gingipains, key P. gingivalis virulence factors, on PgPAD activity was investigated. A limited histological survey was performed on selected tissues to investigate the effect of P. gingivalis in an animal model of adjuvant arthritis. A colourimetric assay to quantify citrulline …
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Isolation of a Pseudomonas aeruginosa Aspartate Transcarbamoylase Mutant and the Investigation of Its Growth Characteristics, Pyrimidine Biosynthetic Enzyme Activities, and Virulence Factor Production
… pyrimidines and decreased ability to produce virulence factors. In this work an organism with a mutation in the second step of the pathway, aspartate transcarbamoylase (ATCase), was created. Assays for pyrimidine intermediates, and virulence factors were performed. Results showed that the …
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The influence of non-inhibitory concentrations of purified pyocin S2 on Pseudomonas aeruginosa isolates
… isolate using S-type pyocins to decrease the virulence of other isolates in a Drosophila melanogaster model. We have reason to believe that this decrease in virulence may not only be because of the direct inhibition of the target isolates but additionally from a reduction in their virulence …
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The Colonization Strategies of Nontypeable Haemophilus influenzae - Bacterial Colonization Factors and Vaccine Development
… currently known, and identify novel, bacterial factors involved in the key processes of colonization and pathogenesis, namely adherence to host tissue and evasion of the host innate immunity. We have shown that the NTHi virulence factor Protein E mediates innate immune evasion by interacting …
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Mechanism of Signal Transduction By The Staphylococcus Aureus Quorum Sensing Receptor AGRC
… its overall population in order to synchronize virulence factor expression with the entire population. This task is carried out by the accessory gene regulator (agr) quorum sensing system. The agr autoinducing peptide (AIP) pheromone activates the AgrC receptor histidine kinase, resulting in …
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Comparative Whole-genome and Phenotype Analyses of Virulence Factors and Lethality in Nematode Challenge Assay among Aeromonas isolates
… septicemia in fish. Although many virulence factors have been described, determining which factors are most important in pathogenesis is ongoing. To examine this further, the genomes of five <em>Aeromonas</em> strains isolated from various animals were sequenced and annotated in …
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Characterization of the Staphylococcus aureus Immunodominant Surface Antigen B, IsaB
… not colonization, suggesting that IsaB may be a virulence factor and a possible novel therapeutic target. Interestingly, IsaB has no homology to proteins of known function and appears to be found only in Staphylococci. We sought to characterize the function of IsaB in S. aureus. We began our …
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Trimming Fat Upon Infection: Proteolytic Demyristoylation as a Novel Bacterial Pathogenic Strategy
… growing antibiotics resistance, understanding of virulence factors utilized by pathogenic bacteria is crucial for developing better treatment for infectious diseases. Shigella spp are food-borne bacterial pathogens and are one of the leading causes of bacterial dysentery worldwide. Similarly to …
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Pyrimidine Enzyme Specific Activity at Four Different Phases of Growth in Minimal and Rich Media, and Concomitant Virulence Factors Evaluation in Pseudomonas aeruginosa
… mortality in immunocompromised patients, given virulence factor production that suppresses antibiotic therapy and promotes persistent infection. This research is the first comprehensive report of the pyrimidine biosynthetic pathway for all phases of growth in minimal and rich media coupled with …
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Head-to-head terpene synthases: Mechanism of action and inhibition
… a carotenoid pigment, and a major virulence factor in S. aureus. Inhibitors targeting CrtM and staphyloxanthin biosynthesis are therefore of interest as “anti-virulence” based therapy for treating S. aureus infection. I studied the structure-activity-relationship of …
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Studies on the Molecular Biology of Naegleru Fowleri and Identification of N. Fowleri in the Environment
… environment, it is also important to determine virulence factors of the ameba. Although virulence factors have not been defined, resistance to complement lysis and production of phospholipases may account for pathogenicity of this ameba. Studies were performed to determine the gene encoding a …
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Role of new virulence mechanisms/factors (type 3 secretion system and TOX-R regulated lipoprotein [TAGA]) in the pathogenesis of the emerging human pathogen Aeromonas hydrophila
… diseases in humans, produces many different virulence factors. A clinical isolate SSU of A. hydrophila possesses a cytotoxic enterotoxin Act, a potent virulence factor that is secreted into the environment through the bacterium’s type 2 secretion system (T2SS) and possesses several biological …
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Role of the lactoferrin-binding protein in pathogenesis of streptococcus uberis
… We hypothesized that Lbp may play a role as a virulence factor. Structural similarity and amino acid sequence homology of Lbp to Mrelated proteins of Group A streptococci suggested a possible functional similarity between Lbp and M-like proteins, which are involved in evasion of host …
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The <i>C. neoformans</i> Cell Wall: A Scaffold for Virulence
… ~180,000 deaths each year worldwide. A primary virulence-associated trait of this organism is the production of melanin. Melanins are a class of diverse pigments produced via the oxidation and polymerization of aromatic ring compounds that have a characteristically complex, heterogenous, and …
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Identification of bacterial pathogenic gene classes subject to diversifying selection
… is dependent on its genomic complement of virulence factors. A bacterial virulence factor, within the context of this study, is defined as any endogenous protein product encoded by a gene that aids in the adhesion, invasion, colonization, persistence and pathogenesis of a bacterium within a …
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