Global ETD Search
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Showing 1 to 15 of 15 for “"virotherapy"”.
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Enhancing Oncolytic Virotherapy Using Functional Genomic Screening
… of cancer patients with oncolytic vaccinia virotherapy has yielded encouraging results in early phase clinical trials, but there are yet unexplored opportunities for improving this therapy that could lead to even better outcomes for patients. To this end, we harnessed the power of functional …
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Improving the effectiveness of oncolytic virotherapy: insights from mathematical modelling
… whose application is not exclusive to oncolytic virotherapy. This framework adopts either a pointwise or a density-based description for the cells, according to their phenotype: transitions between the two descriptions are assumed to happen stochastically and are affected by environmental …
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Targeted Oncolytic Virotherapy Using Newcastle Disease Virus Against Prostate Cancer
… posed by radiation and chemotherapy. Oncolytic virotherapy of cancer is based on the use of replication competent, tumor selective viruses with limited toxicity. Newcastle Disease Virus (NDV), an avian paramyxovirus, is a safe and promising OV successfully used in many clinical trials. NDV is …
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Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy
… the oncolytic virus as a helper virus. Oncolytic virotherapy can recruit NKG2D bearing NK or T cells to the tumor site, and the simultaneous release of these chimeric engagers by the co-delivered amplicons mediate cytotoxicity against tumor cells by crosslinking them with the immune cells via the …
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Evaluation of Adoptive T Cell Therapy and Oncolytic Virotherapy for Treatment of Brain Tumors
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2013-01-22T11:00:26Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Neuroscience Program Dissertations (ID: 630) No. of bitstreams: 3 Thomas_Diana.pdf.txt: 257425 bytes, checksum: …
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The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
… Strategies to improve the efficacy of oncolytic virotherapy have aimed to heighten the immunogenicity of oncolytic viruses, either by incorporating immune-stimulating transgenes or by combining treatments with immune checkpoint blockades. However, such strategies may inadvertently trigger …
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A Partitioned Approach for Computing Fluid-Structure Interaction, With Application to Tumor Modeling and Simulation
… Fluid structure interaction (FSI) and virotherapy on tumor. Moreover, we substantiate a few preliminary results of FSI application on tumor.</p> <p>The FSI problem comprises of fluid forces exerted on the solid body and the motion of the structure affecting the fluid flow. FSI problems …
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ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
… Inside the wide viral repertoire for oncolytic virotherapy, Herpes simplex virus type 1 (HSV-1) stands out, due to its clinically demonstrated efficacy, safety and amenability to genetic modification. Finally, "immunolytic" capacity of HSV conferred by highly immunogenic cell death potential …
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Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer
… transgene nitroreductase for combined oncolytic virotherapy and enzyme/prodrug gene therapy. The latter of these two vectors, vNR6, expressing nitroreductase from the pIX virus promoter demonstrated the greatest cytotoxicity at low virus concentrations however also showed some lytic activity to …
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Virus-Based Nanoparticles for Tumor Selective Targeting and Oncolysis
… NDV-based nanoparticles (VBNP) for oncolytic virotherapy. VBNPs are non-infectious and non-replicating and are relatively safe. We obtained VBNPs by co-expressing matrix (M), hemagglutinin (HN), and fusion (F) proteins of NDV in avian/ mammalian cells. The budding characteristics, size and …
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Inhibition of adenosinergic signaling in the tumor immune environment: the effect of combination CD73 blockade and oHSV therapy on solid tumors
… analysis of patient tumors pre- and post-virotherapy with CAN-3110 revealed increased expression of the adenosine receptor gene <em>ADORA2B </em>after treatment. The accumulation of eADO in the TME is predominantly the responsibility of ectoenzyme CD73 (<em>NT5E</em>) which catalyzes the …
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Sterility and immunogenicity of gamma-irradiated respiratory viruses
Gamma (γ)-radiation is a method commonly applied to sterilise pathogens in the biomedical, food and pharmaceutical industries. γ-radiation inactivates pathogens by causing irreparable damage to genomes to prevent replication. However, proteins and other antigenic structures are left mostly intact. …
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Increased Risk of Cutaneous Immune-Related Adverse Events in Patients Treated with Talimogene Laherparepvec and Immune Checkpoint Inhibitors: A Multi-Hospital Cohort Study
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
<p>Oncolytic HSV-1 (oHSV) treatment induces Notch signaling and myelosuppression in the tumor microenvironment (TME) of preclinical models. In the clinic, upregulation of JAG1 gene expression was observed in recurrent high-grade glioma patients treated with CAN-3110. Since JAG1 is expressed on both …