Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"viral-host interactions"”.
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Interactions between Cucumber mosaic virus proteins and host proteins
… that introduce virus particles directly into host cells. The 2b viral suppressor of RNA silencing (VSR) encoded by CMV is a potent counterdefence and pathogenicity factor that inhibits antiviral silencing by titration of short double-stranded RNAs. The 2b VSR not only influences infection, but …
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Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy
… of tumor cells and indirect augmentation of host anti-tumor immunity. Despite widespread interest in the direct anti-cancer activity of oncolytic viruses, only limited attention has been paid to the interaction between viral therapy and the tumor microenvironment. In Chapter 2 of this …
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Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies
… mechanistically mediated through FcγR-antibody interactions responsible for pathogen neutralization. Human DENV monoclonal antibodies (HmAbs) (1.6D and D11C) isolated from 2 different individuals have been characterized as neutralizing towards all DENV serotypes yet enhancing at sub-neutralizing …
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Evasion of interferon-gamma responses by Toxoplasma gondii in murine and human fibroblasts
Co-evolution of pathogen and host helps drive biological diversity. Unlike viral-host interactions, little is known about the co-evolution of eukaryotic pathogens with their hosts. The intracellular parasite Toxoplasma gondii is an excellent model organism for co-evolution studies because its hosts …
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A Genetic-Proteomic Approach to Identify Cellular Components that Interact with HIV-1
… the cell. Indeed, it is remarkable that the viral genome, comprising only about 0.0003% of the entire genetic capacity of the cell, commandeers the cellular environment to its own advantage. However, to date, only a small group of cellular proteins have been shown to be required for viral …