Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"viral restriction"”.
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Interactions Between APOBEC3 and Murine Retroviruses: Mechanisms of Restriction and Drug Resistance
APOBEC3 proteins are important for antiretroviral defense in mammals. The activity of these factors has been well characterized in vitro, identifying cytidine deamination as an active source of viral restriction leading to hypermutation of viral DNA synthesized during reverse transcription. These …
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Host Proteins Interact with the Hiv-1 Core to Facilitate and Restrict
<p>Host cell proteins, termed restriction factors, which inhibit viral replication at various stages of the viral life cycle, determine the species-specific tropism of numerous retroviruses. Many members of the TRIM family of proteins act as viral restriction factors. One well-characterized example …
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Genetic variation in the IFITM locus and its phenotypic consequences
… proteins have been identified as important antiviral factors. The current understanding of IFITMs suggests that they localise within distinct cellular compartments from where they exert their broad antiviral role. For example, IFITM1 localises to the plasma membrane and restricts viruses that do …
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Role of endogenous retrovirus in control of feline leukemia virus infection and implications for cross species transmission
… retroviruses (ERV) are markers of ancient retroviral infections, though evolutionary forces have limited the capacity for ERV replication and virulence. While they are seldom considered infectious alone, they maintain the ability to interact with their exogenous retroviral (XRV) progenitors. In …
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Characterizing novel molecular regulators of antiviral gene expression
<p>The intracellular innate immune response to viral infection is among the first lines of defense against these pathogens. For the early establishment of an antiviral cellular state and initiation of inflammatory responses, type I interferons (IFNs) are particularly important, as they potently …