Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 285 for “"viral replication"”.
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Functional Role of Hepatitis B Virus Core Protein in Viral Replication
… of HBV core protein for hepatitis B virus (HBV) replication, chimeric HBV core proteins were generated by substituting varying lengths of the carboxyl-terminus of duck hepatitis B virus (DHBV) core protein for the corresponding regions of HBV core protein. All chimeric core proteins formed core …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
… cancers. ORF59, a DNA processivity factor of the viral DNA polymerase, is essential for lytic reactivation and is highly expressed during de novo primary infection. To better understand the role of ORF59, we performed an ORF59-immunoprecipitation from KSHV infected cells and identified ORF59 …
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The Role of ORF59 and PAN ENE in Viral Replication of KSHV
… malignancies. During reactivation, multiple viral and cellular factors are required to ensure progression through the KSHV viral lytic cycle. One of these factors is the viral polymerase processivity factor ORF59. The main functions of ORF59 are to localize the viral polymerase to the nucleus …
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The roles of papain-like protease-related proteins in viral replication and host immunity
Viral papain-like proteases (PLPs)-related proteins have been shown to be actively involved in host innate immunity manipulation and virus replication. In this dissertation, the research were focused on the elucidation of biological roles of nidoviral PLPs-related proteins in innate immunity …
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Understanding Host-Pathogen Interactions of Rift Valley Fever Virus That Contribute to Viral Replication
… identified three host-protein interactors of the viral Gn and L proteins that aid in viral replication. UBR4 was determined to be an interactor of Gn via immunoprecipitation followed by either LC/MS/MS or western blot analysis. Its inhibition via siRNA or CRISPR-Cas9 knockout showed a reduction of …
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Cytokine patterns in a comparative model of arenavirus infection: Implications for virulence and control of viral replication
… associated with a suppression of potentially antiviral cytokines early in infection, and high levels of potentially pathogenic pro-inflammatory cytokines late in infection. Cytokine responses to P2 and P18 infection were measured from primary guinea pig peritoneal macrophages (PM) in vitro when …
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CHARACTERIZATION OF HUMORAL RESPONSE TO EPSTEIN-BARR VIRUS (EBV) INFECTION AND PROTEIN KINASES INVOLVED IN VIRAL REPLICATION
… B lymphocytes into plasma cells may activate viral lytic program in latently infected cells leading to a coordinated expression of majority of viral genes and production of progeny virions. Although most infections are asymptomatic, the primary clinical manifestation of EBV infection is …
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Discovering LC3-interacting region (LIR) motifs in hemorrhagic fever viruses: Implications for host autophagy and viral replication.
… infection can enhance our understanding of viral replication and lead to potential host-based therapeutic targets. Rift Valley fever virus (RVFV) is a HFV that causes significant disease in humans and livestock and was an initial model HFV for the present study. The RVFV nonstructural small …
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HIV-infected women who do and do not report intimate partner violence: Viral replication and adherence to antiretroviral medications
… relationship between intimate partner violence, viral replication and adherence to antiretroviral medications among HIV-infected women were identified. This research examined antiretroviral adherence and viral replication among HIV-infected women who did and did not report intimate partner …
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MicroRNA-122 and Poly(C)-Binding Protein 2 Bind to the Hepatitis C Virus Genome, Regulating Viral Replication and Genome Structure
… genome which is used as the template for both viral translation and negative-strand RNA synthesis. As both processes work in opposite directions on the genome the virus requires a mechanism to coordinate what process is acting on a given copy of genome. It has been suggested that the host …
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Induction of the <em>Chlamydia trachomatis</em> Persistent State by Herpes simplex Virus Type 2 Does Not Require Productive Viral Replication.
… chlamydial persistence; (ii) productive HSV-2 replication is required for induction of persistence in <em>C. trachomatis</em>; (iii) co-infection with <em>C. trachomatis</em> and HSV-2 alters accumulation of immuno-modulatory molecules in infected cells. To test these hypotheses, a cell culture …
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Understanding the Role of the Hypervariable Region in the Open Reading Frame 1 of the Hepatitis E virus in Viral Replication
… a major cause of enterically transmitted acute viral hepatitis in developing countries that lack proper hygienic infrastructure. Hepatitis E is globally distributed and has emerged as an important public health disease in both developing and industrialized countries. HEV is a non-enveloped virus …
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Design of a Tetracycline Operon Inducible System for the Control of Vaccinia Virus Replication: Implications for Vaccine Development
… to the effectiveness of VACV as a vaccine and viral vector include its ability to elicit strong, long-lived humoral and cell-mediated immune responses as a live-replicating virus and to accept large inserts of DNA into its genome. However, adverse events associated with its use as the smallpox …
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Molecular Mechanisms of Host Responses to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection
… of the molecular mechanisms involved in the replication of the virus. In order to better understand the molecular mechanisms of host responses to PRRSV replication, we first sought to evaluate the ability of the virus to induce stress granules (SGs) during PRRSV infection. SGs are …
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Functional Analysis of the Human Cytomegalovirus Ul82 Gene Product PP71 Protein During Virus Replication
… shown that pp71 is required for efficient virus replication at low multiplicities of infection and that it is a regulator of immediate-early gene expression. However, the mechanism whereby pp71 regulates IE gene expression and/or virus replication has not been elucidated. pp71 has also been shown …
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The hepatitis B core promoter: Control of viral life cycle events
… aimed to investigate the importance of the CP in viral replication. Pairedsamples, pre- and post HBeAg seroconversion, were selected from 14 chronic HBVpatients who had a significant decrease in serum viral load after HBeAgseroconversion implying a drop in viral replication. The CP acitivty from …
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The Interaction Between Host G3BP and Viral Nucleocapsid Protein Regulates SARS-CoV-2 Replication
… response to various cellular stresses, including viral infection. G3BP1/2 are prominent interactors of the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the functional consequences of the G3BP-N interaction in the context of viral infection have …
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The mechanism of component recognition of bipartite geminiviruses: Genetic studies of the replication of squash leaf curl virus, and, Genetic and functional studies of squash leaf curl virus coat protein AR1
… geminiviruses encode functions essential for viral infection: the A component replicates the viral genome and the B component systemically spreads the virus throughout the host. Thus, correct recognition between the two components is required to ensure a constant co-presence of the two viral …
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Modeling of [¹⁸F]-FHBG in tumor and normal tissues
… cancer treatment is dependent upon selective viral replication within cancer cells. In order for viral oncolysis to be successful in the clinical setting, the biodistribution of viral replication must be quantified. This study has used an enzyme-based positron emission tomography (PET) …
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