Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"viral rebound"”.
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Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following Discontinuation of ART
The earliest events of viral rebound following discontinuation of ART in people living with Human Immunodeficiency Virus-1 remain largely unknown. We investigated detailed reservoir characteristics and viral rebound dynamics in 18 Simian Immunodeficiency Virus-infected rhesus macaques treated with …
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Therapeutic Uses of Broadly Neutralizing Anti-HIV-1 Antibodies in Humanized Mice
<p>Combination anti-retroviral drug therapy (ART) significantly suppresses HIV-1 viremia in most infected individuals, but is incapable of curing disease. The major barrier to HIV-1 cure is a population of long-lived cells that harbor replication-competent provirus and are refractory to current …
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Mathematical models of coreceptor usage and a dendritic cell-based vaccine during HIV-1 infection
… dendritic cells based vaccine could reduce the viral load but not eliminate the virus resulting in a viral rebound. To maintain a low viral load, vaccination would have to be repeated. Unfortunately, repeated vaccination may lead to the overproduction of proinflamatory cytokines resulting in …
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Efficacy of Antibody and T cell Therapies for Highly Mutable Viruses like Human Immunodeficiency
… we develop a stochastic computational model of viral dynamics to help characterize the regimes where viral control or cure may be possible. We study the efficacy of either bnAb therapy or therapeutic vaccination that elicits T cell responses that target mutationally-constrained regions, as well …
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Evaluating individuals with extreme phenotypes of HIV-1 contributes towards better healthcare management of all HIV-1 positive individuals
… immediately initiating combination antiretroviral therapy (cART) (vs not immediately initiating) among those with high CD4 cell counts (>500cells/mm3) and high HIV-RNA (>100,000 copies/ml). We contributed towards the ‘what cART to start’ question; among individuals initiating boosted protease …
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Development And Validation Of Novel Transmitted/founder Shivs For Hiv-1 Persistence And Cure Research
… at Env residue 375 that confers consistent early viral kinetics in RM, although longitudinal kinetics are more variable. Further, TF SHIVs have not been evaluated for their suitability for HIV latency and cure research. For my first aim, I evaluated two promising TF SHIVs, SHIV.191859 and …
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Virologic outcomes of HIV-infected children undergoing a single-class drug substitution from Lopinavir/Ritonavir- to Efavirenz-based antiretroviral treatment: A retrospective cohort study
… of excellent adherence to combination antiretroviral therapy (cART) lifelong is required to achieve optimal benefits. In addition, treatment options for children are limited by potential drug-resistance following PMTCT exposure, availability of appropriate and palatable formulations, long-term …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… can reside and replicate even under antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown to lead to viral rebound independently. In response to the environmental stimuli, macrophages can be polarized into different phenotypes: the …
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A control theoretic approach to mitigate viral escape in HIV
… long asymptomatic period and a final increase in viral load with a simultaneous collapse in healthy CD4+T cell count during which AIDS appears. Motivated by the worldwide impact of HIV infection on health and the difficulties to test in vivo or in vitro the different hypothesis which help us to …
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Single-molecule diagnostics to support curative interventions for tuberculosis and HIV
… of HIV cures and longer-acting antiretroviral medications. These depend on a deeper understanding of the biology of HIV, and when they are ready for clinical trials, will also need highly sensitive tests to characterize the virus-host interactions and determine whether they are working. …
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Single Cell Analysis of the HIV-1 Latent Reservoir
… of HIV-1 infection with combinations of antiretroviral drugs has significantly reduced the death rate and improved the quality of life of HIV-1 infected individuals. Despite over thirty years of HIV-1 research, however, both a cure and a vaccine remain elusive. Complete eradication of HIV-1 by …