Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"viral quasispecies"”.
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Computational Methods for Haplotype-aware De Novo Genome Assembly from Long Reads
… are particularly applied in diploid genome, viral quasispecies, polyploid genome and metagenome, respectively. Briefly, these methods firstly perform haplotype-aware sequencing error correction using different strategies, and subsequently construct haplotype-aware sequence graphs to generate …
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Genetic diversity of subtype C HIV-1 env variants in peripheral blood mononuclear cell (PBMC) DNA from infected mother-child pairs : a comparison of Heteroduplex Mobility Assay (HMA) and Base Excision Sequence Scanning (BESS) methods
… seen over time. The monitoring of changes in viral sequences can provide important information on the nature of the immune response and the correlates of protection. Viral diversification may also occur due to other selective pressures such as cell availability and differences in viral …
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Identification of Viral Determinants of Murine Norovirus Pathogenesis
… importance as human pathogens, knowledge of the viral life cycle and host pathogenesis is limited due to the lack of practical models to study. In contrast, murine norovirus: MNV) has been a critical surrogate for the study of human noroviruses as it is the only member of this genus that …
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Diversity in APOBEC3 and CCR5 host genes and HIV-1 in a South African population
… public health concern, even though Antiretroviral drugs (ARV), especially Highly Active Antiretroviral Therapy (HAART) has significantly reduced morbidity and mortality due to AIDS globally in developed and developing countries. However, there is still a great need to explore every avenue for …
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Genotypic and Molecular Determinants in the Continued Evolution of West Nile Virus in the United States
… progress has been made dissecting how and when viral outbreaks occur; therefore, the objective of this dissertation was to investigate both genotypic and molecular determinants involved in continued evolution of WNV by relating in silico and in vitro differences in the molecular epidemiology, …