Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 140 for “"viral proteins"”.
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Capsid catalysis : de novo enzymes on viral proteins
… to reactions in myriad solvents. As the viral structure ensures semisynthetic enzymes remain linked to the genetic sequences responsible for catalysis, future work could tailor the biocatalysts to high-demand synthetic processes by evolving new activities, utilizing high-throughput …
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Computational investigation of membrane-associated phenomena and viral proteins
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
The search for new targets and antiviral agents is continuously growing, especially for agents with broad-spectrum activity. In fact, even though vaccines are the elective way to limit diseases and possibly eradicate pathogens, they are not always effective, particularly in people with compromised …
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The introduction of incompatibility between Junin virus Z protein and other viral proteins results in impaired replication and attenuation
… vitro characterization results of these chimeric proteins indicated that both domains I and III likely contribute to incompatibility with Can Z. These studies characterize a novel attenuation method for JUNV utilizing the Z protein in addition to elucidating further mechanisms caused by Z …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… an innate immune response that generates antiviral state to prevent virus replication and spread by expressing several IFN-stimulated genes. Type I interferon response depends on a set of germ-line encoded receptors called pattern recognition receptors (PRRs) that initiate antiviral signaling …
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Autophagy in Antiviral Immunity
… novel host genes involved in targeting viral proteins to the autophagy pathway. We found that the HSV-1 encoded neurovirulence protein ICP34.5 interacted with the host autophagy protein Beclin 1, and that this interaction was essential for HSV-1 neurovirulence. This was the first example …
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Host Modulators of the Death Response to Influenza A Infection
… include vaccines and drugs that target viral proteins. However, both of these approaches have limitations, as vaccines require yearly development and the rapid evolution of viral proteins gives rise to drug resistance. In consequence additional intervention strategies, that target host …
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Molecular Mechanisms Behind Sars-Cov-2 Induced Host Genome Restructuring
… and more severe than changes caused by other viral infections or immune stimulants. While these changes at the chromatin level are important for understanding the immune dysregulation seen in some cases of COVID-19, the underlying viral mechanism by which these changes occur remains unclear. …
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MOLECULAR MECHANISM OF HIV-1 TAT INDUCED NEURONAL DYSFUNCTION
… with the development of highly active antiretroviral therapy (HAART), many infected with HIV-1 are living much longer. In fact, it is estimated that by 2015, about half of all HIV-positive individuals will be older than 50. Yet those over 50 also progress to AIDS faster than adults in their 20s …
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Chaperoning viral protein evolution
Preventing viral pandemics and developing effective antiviral therapeutics demands understanding the molecular mechanisms that both potentiate and constrain viral evolution. The rapid evolution of viruses is mediated in part by their high mutation rates, enabling resistance to antiviral drugs, …
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Analysis of factors that affect parvovirus expression
… active in temporal order during infection. BPV proteins also appear in the same temporal order; the nonstructural (NS) proteins are produced before the capsid proteins. Northern blot analysis of BPV RNAs suggest that, like human parvovirus B19, all transcripts of BPV are initiated from a single …
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Single molecule pull-down of viral RNA-protein complexes
… a powerful tool that allows detection of diverse proteins present in a single complex and quantitation of the number of interacting partners when the proteins are stoichiometrically labeled. Using a similar principle, the objective of this study is to extend the SiMPull assay to isolate and study …
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The viral protein R in HIV-associated acute ischaemic stroke: a case-control study
Background: HIV-1 viral proteins have been implicated in endothelial dysfunction, which is a major determinant of ischaemic stroke risk in HIV-infected individuals. Polymorphisms in HIV-1 viral protein R (Vpr) may alter its potential to promote endothelial dysfunction, by modifying its effects on …
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Purification of Human Immunodeficiency Virus Type 1 Preintegration Complexes by Velocity Gradient Centrifugation.
… complexes are responsible for the conversion of viral RNA into viral DNA, transport through the cytoplasm, import into the nucleus, and the subsequent integration of the viral genomic DNA into the host chromosomal DNA. Several viral proteins are associated with the NPCs, including reverse …
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A Genetic-Proteomic Approach to Identify Cellular Components that Interact with HIV-1
… the cell. Indeed, it is remarkable that the viral genome, comprising only about 0.0003% of the entire genetic capacity of the cell, commandeers the cellular environment to its own advantage. However, to date, only a small group of cellular proteins have been shown to be required for viral …
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Characterization of the GBF1-Arf1 axis in enterovirus RNA replication
… the development of specialized domains harboring viral replication complexes, called replication organelles. The cellular protein Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1) is essential for the replication of enteroviruses, but its molecular role in the …
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Formation of membrane domains induced by the G and M proteins of vesicular stomatitis virus
… cells. These domains are composed mainly of viral proteins and they are enriched in certain lipid species. The properties of the two envelope-associated proteins of VSV, the glycoprotein (G) and the matrix protein (M), were investigated in reconstituted lipid vesicles in order to understand …
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Defining the Influence of Host Cell Proteostasis Networks and Temperature on Influenza Evolution
… to synthesize, fold, and degrade their proteins. These proteostasis machineries can influence the accessible sequence landscape of viral proteins, and thus shape their evolution. Furthermore, the entire viral replication cycle takes place within the host cell. Therefore, the environment …
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An ultrastructural and immunocytochemical study of the wheat soil-borne mosaic virus, Polymyxa graminis relationship
The effects of various fixatives on viral suspensions, the progress of wheat soil-borne mosaic virus (WSBMV) through Florida 302 wheat, and WSBMV relationship to Polymyxa graminis Led. were studied at the subcellular level. The utilization of electron immunocytochemical techniques using …
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Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
… lytic or latent infection. Latency is a state of viral quiescence where the virus can persist indefinitely yet remain poised to reactivate. Latency is unique to herpesviruses and key to HSV's success, but the molecular mechanisms that govern this state are unclear. A virus-encoded E3-ubiquitin …
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