Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"viral life cycle"”.
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The hepatitis B core promoter: Control of viral life cycle events
… aimed to investigate the importance of the CP in viral replication. Pairedsamples, pre- and post HBeAg seroconversion, were selected from 14 chronic HBVpatients who had a significant decrease in serum viral load after HBeAgseroconversion implying a drop in viral replication. The CP acitivty from …
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Conserved Residues in Murine Papillomavirus E2 Regulate the Viral Life Cycle
… successfully navigate the three stages of its life cycle: establishment, maintenance, and vegetative amplification. A major mechanism of regulating this viral program is post-translational modification on the viral E2 protein, which is responsible for orchestrating viral transcription, …
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Investigating the mechanisms of BK Polyomavirus egress and virus-host interactions.
… 70 – 90% of the world’s population and causes a lifelong, silently persistent infection. In immunocompromised individuals, BKPyV replication can result in serious pathology. Bone marrow transplant patients can develop haemorrhagic cystitis, and in kidney transplant patients BKPyV replication can …
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The Intracellular Kinetics of HIV-1 Replication
… rate of HIV-1 replication has an impact on the viral loads patients have and the time it takes for an infection to progress to AIDS. This replication rate is defined partly by the time it takes an infected cell to begin producing new infectious virus, and this, in turn, is defined by the time …
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HIV-1 protease as a target for antiretroviral therapy
… (AIDS). HIV employs three enzymes in its lifecycle, including a protease that enables maturation of polyprotein precursors. Despite decades of progress studying the lifecycle of HIV and elaboration of therapeutics targeting nearly every aspect of the viral life cycle, a cure remains …
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Host Proteins Interact with the Hiv-1 Core to Facilitate and Restrict
… termed restriction factors, which inhibit viral replication at various stages of the viral life cycle, determine the species-specific tropism of numerous retroviruses. Many members of the TRIM family of proteins act as viral restriction factors. One well-characterized example is the ability …
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Host Modulators of the Death Response to Influenza A Infection
… include vaccines and drugs that target viral proteins. However, both of these approaches have limitations, as vaccines require yearly development and the rapid evolution of viral proteins gives rise to drug resistance. In consequence additional intervention strategies, that target host …
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Development and characterization of an in vitro culture system as a physiological model for chronic Hepatitis B infection
… viruses that specifically target hepatocytes for viral replication. Although a vaccine has been available for more than 20 years chronic HBV infection afflicts 350-400 million worldwide. It is estimated that 0.5-1.2 million people die each year from HBV-attributable cases of chronic hepatitis, …
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Immunomodulation der Kartoffel-Blattrollvirus (PLRV) Multiplikation via Expression virusspezifischer rekombinanter Antikörper in planta
… of P1 and/or its derivate P1-C25 to the viral life-cycle the VH- and VL-domains of a monoclonal antibody mAbP1-C25 raised against the carboxy terminus of P1 was cloned in order to obtain a single chain variable fragment scFvP1-C25 that was subsequently analysed. The resulting antibody was …
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Dynamics of HIV-1 Infection and Therapy In Vivo
… while treatable with suppressive antiretroviral therapy drugs (ART), establishes lifelong persistence in the infected host as a natural consequence of the viral life cycle and the dynamic properties of the human immune cells in which HIV-1 propagates. This persistence is driven by …
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Dissecting the Contribution of the Carboxyl-Terminal Domain and Tail of HIV-1 Integrase to Viral Dynamics and Enzymatic Function
… Deficiency Syndrome (AIDS). Combination antiviral therapy has proven to be particularly effective at suppressing viral replication, yet complete eradication of the virus from an infected individual remains elusive. Recently, a new class of antiviral drugs targeting the viral integrase (IN) …
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Murine Cytomegalovirus Encodes Proteins that Regulate Viral Late Transcription
… (including AIDS patients), and is the leading viral cause of congenital birth defects. Murine Cytomegalovirus (MCMV) is the primary surrogate model for HCMV, and resembles the human virus with respect to virion structure, genome organization, gene expression, tissue tropism, and clinical …
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Understanding the Host Cellular Response to Astrovirus Infection
… known that autophagy can play a key role in the viral lifecycle, from entry to egress, and can be either pro-virus or pro-host depending on the virus. RNA viruses often exploit autophagy machinery to create double membrane vesicles (DMVs) as sites of replication and to protect viral RNAs from …
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Towards an antibody mediated resistance against Geminiviruses
… AV1 (coat protein) and AC1 (replicase enhancer) viral proteins were used for mice immunization and screening of phage display libraries and hybridoma clones. The binding properties of the isolated scFvs were determined by western blot, ELISA and BIACORE. The missing nucleotide found in the …
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Genetic and Biochemical Analyses of the Flaviviridae Capsid Proteins
… including hepatitis C, yellow fever, and bovine viral diarrhea. Efficient dissemination of these viruses is dependent on the production of infectious particles, thought to arise by budding of the capsid protein and associated genomic RNA through a host cell-derived lipid membrane outfitted with …
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Viral and cellular proteins involved in vaccinia virus egress
… site of replication. It has a complex life cycle that produces two distinct infectious virion forms, Intracellular Mature Virions (IMVs) and Extracellular Enveloped Virions (EEVs). The host cell microtubule trafficking machinery is hijacked by the virus at three distinct positions of …
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THE ADENOVIRUS E1B-55K AND E4ORF6 PROTEINS LIMIT PKR-MEDIATED EIF2A PHOSPHORYLATION DURING THE LATE PHASE OF INFECTION
… and E4orf6 proteins promote efficient late viral gene expression. The results presented in this dissertation reveal that the E1B-55K and E4orf6 proteins facilitate late viral protein synthesis by limiting phosphorylation of eIF2α by the dsRNA-dependent protein kinase R (PKR) during the late …
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Identification of Viral Determinants of Murine Norovirus Pathogenesis
… importance as human pathogens, knowledge of the viral life cycle and host pathogenesis is limited due to the lack of practical models to study. In contrast, murine norovirus: MNV) has been a critical surrogate for the study of human noroviruses as it is the only member of this genus that …
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Progress Towards Integrated Models of HCV Dynamics
… a complex regulatory scheme involving numerous viral and cellular components and which may be the key to its striking success in initiating and maintaining decades-long chronic disease in infected individuals. Lacking any known latent or integrated form, HCV must persist through ongoing RNA …
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RBP-J dependent and independent signalling of EBNA-2
EBNA-2 is a multifunctional viral oncogene involved in the immortalisation of B-cells by EBV. EBNA-2 regulates transcription of viral and cellular genes in the proliferative phase of the viral life cycle, which in vitro results in the outgrowth of EBV positive B-cells into lymphoblastoid cell lines …
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