Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"viral latency"”.
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FROM A PLACODE PROGENITOR PLATFORM TO A TRIGEMINAL GANGLION ORGANOID: MODELLING SENSORY DEVELOPMENT AND FUNCTION IN VITRO
… several human pathologies, such as migraine and viral diseases, including the establishment of viral latency in trigeminal sensory neurons by herpesviruses. TG-associated pathologies remain poorly understood in part due to a lack of human, scalable in vitro models of the ganglion. Human …
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Cell intrinsic innate immunity protein RPRD2 restricts transcription from the HIV-1 LTR in human cell lines
HIV-1 establishes latency after infection in resting CD4+ T-cells which prevents the host from clearing the virus. Highly active antiretroviral therapy effectively keeps HIV replication under control, however, the latent reservoir remains unaffected, thus therapy is never curative. The …
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Virus-Host Interactions during Epstein-Barr virus Latent Infection of B cells
… choice, and iii) host factor regulation of the viral latent/lytic switch. Here we undertook biochemical and structural approaches to investigate the protein-protein interactions between viral latency-associated proteins and RBPJ. This revealed new information differentiating the surfaces of RBPJ …
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Temporal Regulation of LMP1 and Apoptosis Resistance After Primary EBV Infection
… thought to be critical for the establishment of latency) is quite poor. We hypothesize that the interactions between the virus and the human host early after infection are ultimately important for the outcome of viral latency establishment. To answer this question we broadly profiled primary …
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Molecular Mechanisms and Host Factors Involved in HIV-1 Latency
… by host immune surveillance and antiretroviral therapy. This phenomenon is called proviral latency and the cells harbouring such viruses are part of the latently infected cell reservoir. In this situation, the viral genome integrates into the host's genome upon infection, whereby infected …
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Interdependent Regulation of Cytomegalovirus Proteins in Complex
… cytomegalovirus (CMV) pathogenesis as sites of viral latency and by supporting viral replication and disseminating virus throughout the body. We previously found that the localization of the M140/M141 gene products (pM140/pM141) is different when the proteins are co-expressed as compared to …
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Modulation of innate immune responses in nasopharyngeal epithelial cells by the Epstein-Barr virus (EBV)-encoded latent membrane proteins LMP2A and LMP2B
… B-cells, preventing BCR signalling and ensuring viral latency. Much less is known about the function of these proteins in epithelial cells, although LMP2A has been shown to modulate Wnt/\(\beta\)-catenin, MAPK and PI3K/Akt signalling, whilst LMP2A and LMP2B have been shown to promote cell …
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Pseudorabies Virus Latency Associated Transcript Gene: Expression, Regulation, and Role in the Establishment of Latency in Swine
… presented in Chapter 1 demonstrate that the PrV latency associated transcripts (LAT) gene is also active during an in vitro productive infection. Three polyadenylated [poly(A)] RNAs (about 1.0, 2.0, and 8.0 kb) made during a lytic in vitroinfection share similar physical properties with the in …
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Cellular and viral factors affecting HIV-1 silencing and reactivation
… approach. Here the established model system of latency ‘J-lat’ is used to probe optimum reactivation signals. Single clones are observed to respond to maximal stimulation with a single agent with a fixed proportion of cells. Here it is shown that this proportion can be overcome by dosing with …
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Modelling the impact of prevention strategies on cervical cancer incidence in South Africa
… Using simulated vaccine trials, we show that viral latency and reactivation of latent infections is necessary in the natural history of HPV to match results from empirical trials. The model's screening algorithm reflects findings from the Western Cape's public health sector – low levels of …
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Intrinsic Control Strategies for Herpesvirus-based Vaccine Vectors
… is based on deletion of a gene essential for viral latency to modify persistence in vivo. Studies by Thirion et al have shown that the bovine herpesvirus 4 (BoHV-4) ORF73 gene product is required for persistence through enabling episome tethering to mitotic chromosomes. The first aim of the …
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Characterisation of T cell responses to proteins expressed during Human Cytomegalovirus latency
… immune response to primary HCMV infection limits viral replication and dissemination, such that overt clinical disease is prevented. However, the immune system cannot prevent the virus establishing a latent infection, which enables lifelong persistence. Historically, a long-standing view was that …