Global ETD Search
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Showing 1 to 8 of 8 for “"viral integration"”.
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Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis
… (HPV) is the causative agent of cervical cancer. Integration of the HPV genome into the host genome is a key event in cervical carcinogenesis, with oxidative stress (OS) likely playing a major role in promoting DNA damage, and subsequently, integration. In our current study, we demonstrated a …
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The Influence of HIV-1 Subtype C LTR Genotype on Latency Potential
The persistence of latent viral reservoirs, that are insensitive to antiretroviral therapy (ART), remains the greatest barrier to HIV-1 eradication. The role that viral factors play in HIV-1 latency establishment and maintenance is poorly understood, and characterisation of these factors is …
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The Role of Meis1 in Hematopoietic Development
… cells, we identified myeloid ecotropic viral integration site 1: <italic>Meis1</italic>).</p><p>Meis1 forms a heterodimer with Pbx1 that augments Hox-dependent gene expression. In addition, <italic>Meis1</italic> has been associated with leukemogenesis and hematopoietic stem cell …
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The Impact of Radiation on Glioblastoma Evolution
… differences in survival, morphology/histology, Viral integration site analysis (VISA), and WES. Irradiated mice experienced a survival advantage and harboured less invasive tumours compared to control mice. VISA revealed that control tumours harbour fewer clones than in vitro lines and that …
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Pan-Cancer Genomic Characterization of Human Papillomavirus Associated Tumors
… to promote HPV-associated cancer formation. HPV integration rates vary by HPV genotype and anatomic site, and some studies have suggested that viral integration, viral load, and HPV type influence HPV-associated tumor prognosis. However, methods for determining HPV status, viral load, and …
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Chromosome and Genome Evolution in Culicinae Mosquitoes
… of the Ae. albopictus genome as well as mapping viral integration and polyphenol oxidase genes. Moreover, comparing our present Ae. albopictus physical map to the current Ae. aegypti assembly indicated the presence of multiple chromosomal inversions between them. To better understand population …
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Characteristics of an Endonuclease Associated with Adenovirus Types 2 and 12
… cellular DNA which contains some integrated viral DNA. The species which cosediments with DNA extracted from the mature virions is homogeneously distributed. This species represents the intact viral genome. The species of DNA which sediments slowly is homogeneously distributed hybridizes only …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
… are in urgent needs. Meis1 (myeloid ecotropic viral integration site 1) gene belongs to the three-amino-acid loop extension subclass of homeobox gene families, and it is a highly conserved transcription factor in all eukaryotes. Up to date, little is known about the role of Meis1 in regulating …