Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"viral inhibition"”.
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Viral Inhibition of Mammalian Cell DNA Synthesis
<p>Eukaryotic cells replicate their DNA during a defined time period in the interphase between mitoses. Non-proliferating cells are generally found to be blocked in interphase prior to the DNA-synthetic period. It therefore appears that the control of cellular proliferation may be intimately …
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Glycoprotein mimetic materials - synthetic methods and study of viral inhibition properties
The human body houses some of the most unique materials on the planet and is a promising source of bioinspiration. The high molecular weight and glycosylation of mucin-type glycopeptides make them challenging to produce or even mimic. This material production challenge is one of the key limiting …
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Regulation of APOBEC3 activity and HIV-1 replication by P-body associated proteins
… play an important role in host mediated antiviral defence against retroelements, including HIV-1. Although much has been discerned regarding the anti-viral nature of these proteins, their cellular function, as well as mechanisms of functional regulation and cellular co-factors, remains poorly …
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HIV-1 Vpu Oligomerization in Membrane Mimetics
… for HIV-1 infection improve, new targets for viral inhibition have provided a means to reduce a once-lethal infection into a manageable chronic condition. Among other proteins, HIV-1 encodes the Vpu accessory protein which upregulates the process of viral release from infected cells, providing …
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Mononuclear phagocyte activation and its role in HIV-1 pathogenesis
… productive HIV-1 infection and that the level of viral inhibition was dependant on the polarization phenotype. Ml and M2a polarized MDM also differed in the capacity to transmit virus to CD4+ T cells with M2a cells efficiently transmitting HIV-1 via a DC-SIGN dependant mechanism. In a cohort of …
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Effect of Chinese Knotweed Extract on HSV-1 Infection of Vero Cells
… no signs of cytotoxicity. In order to quantify viral inhibition and determine the compounds potential mechanism of action (MOA), plaque reduction and binding assays were performed. These assays suggest that 0.1% CK concentrations are able to reduce viral infectivity by >99% by inhibiting viral …
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Biochemical and structural characterization of radical SAM enzymes Elp3 and viperin
… of the Elongator complex. The first response to viral infection in mammalian cells is the induction of the interferon system, which activates IFN-stimulated genes (ISGs) to inhibit various stages of viral replication. Viperin (for virus inhibitory protein, endoplasmic reticulum associated, …
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Natural Killer Cell Recruitment and Activation Following Orthopoxviral Infection
… cells and cytokine production. The innate anti-viral response following infection is associated with NK cell population expansion in draining LNs, where they are normally a rare population. We have identified mechanisms underlying NK cell expansion following orthopoxviral infection and have …
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Investigating Interferon-Inducible Antiviral Effectors Through a Virological and Evolutionary Lens
Interferons control viral infection by inducing expression of effector proteins encoded by interferon-stimulated genes (ISGs). The field has focused on identifying antiviral ISG effectors and defining their mechanisms of action. However, fundamental gaps in knowledge about the interferon response …
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Drug Resistance Mutations in Naive HIV-1 South African Patients, and Construction of Molecular Clones to Phenotype Putative Resistance Mutations
… is still low. Although combination antiretroviral therapy has resulted in a considerable improvement in the treatment of human immunodeficiency virus type 1 (HIV-1) infection, the emergence of resistant virus is a significant obstacle to the effective management of HIV infection and AIDS. …
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Counteracting Neuroinvasive RNA Viruses: Antiviral and Immune Modulation Strategies Against SARS-CoV-2 and VEEV
… played a critical role in decreasing viral spread among communities. In instances where social distancing practices were implemented (minimum 6 feet), people quarantine upon feeling ill or exposure to positive cases, proper mask usage by both the infected and uninfected individual, and …