Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 173 for “"viral infections"”.
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Equine innate and adaptive immunity to viral infections
… receptor for unmethylated bacterial and viral cytosine-phosphate-guanine DNA (CpG-DNA). West Nile virus (WNV) infection may result in meningitis and encephalitis in humans and horses, especially aged and immunocompromised individuals. Using flow cytometric analyses and quantitative …
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Comparative Respiratory Tract Pathology of Emerging Viral Infections
… could then be used to develop broad spectrum antivirals or vaccines. As such, we focused our studies on two recently emerged viruses, Nipah virus and the Middle East respiratory syndrome coronavirus (MERS-CoV), which have caused significant respiratory disease and death in humans.
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Spillover and emergence of bat-origin viral infections
… characterise the system dynamics of bat-origin viral emergence events. Chapters 2–5 are comprised of four quantitative analyses: a compartmental model comparison of stochastic henipavirus serological dynamics in captive bats (Eidolon helvum in Ghana), a quantitative literature review of …
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Helminth, protozoan and viral infections of the European eel, Anguilla anguilla
… latent.Overall, the prevalence of triple co-infections (A. crassus, T. granulosum and H.anguillae), varied significantly according to sampling location; however, there was noassociation between these infectious agents.
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Integrative analysis of transcriptional activity and genome architecture changes upon viral infections
… architecture and transcriptional activity during viral infections, I employed a genome-wide chromosome conformation capture approach (Hi-C) on infected murine and human cells and further enriched those libraries for genomic loci of interest and the viral genomes with biotinylated RNA baits. In …
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Modulators of Innate Gut Immunity to Enteric Viral Infections: Murine Norovirus (MNV) as a Model
… by the increased burden of gastrointestinal infections at the extremes of age. In this thesis, using the Murine Norovirus (MNV) oral infection model, I aimed to characterize intestinal mucosal antiviral-responses with specific focus on the role of IELs, the impact of aging and the influence …
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Within Host and Multiscale Models of Usutu and SARS-CoV-2 Viral Infections with Animal Hosts
… to uncover mechanistic interactions governing viral infections. To acquire a holistic understanding of the impact of viral infections, it is necessary to develop mathematical techniques and models that bridge knowledge on multiple biological scales. This dissertation explores the relationship …
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Plant Viral Infections as Influenced by Extracts From Some Known or Suspected Hosts of Stone-Fruit Viruses
Made available in DSpace on 2014-12-05T20:30:11Z (GMT). No. of bitstreams: 1 6003925.pdf: 2885495 bytes, checksum: a225bff512083183f64cadada1f03eb1 (MD5) Previous issue date: 1960
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ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS
… is the main line of defence against mucosal infections as it can provide pathogen blocking secretory IgA at the mucosal surface. CCL28 is a chemokine that binds to CCR3 and CCR10 and potently recruits IgA-secreting plasma cells (IgA-ASCs) in the mucosal lamina propria. Virus-like particles …
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Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
… therapeutic target in cancer and chronic viral infections, where blockade of PD-1/PD-L1 reverses CD8+ T cell exhaustion and improves outcomes. However, it remains unclear how PD-1 pathway signals shape the development and maintenance of memory CD8+ T cell responses following …
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The Virome in Primary and Secondary Immunodeficiency
… have historically been attributed to overt infections caused by bacterial and fungal pathogens. For this reason, treatment methods have focused on resolving these infections, with great success in terms of reducing short-term morbidity and mortality rates. This initial success only served to …
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Role of Multiple Toll-Like Receptor Activation in Regulating Cytotoxic T Cell Priming to Lympocytic Choriomeningitis Virus Infections
… activation and affect their abilities to clear viral infection. However, how TLR ligands (TLR-L) can regulate CD8+ T cell responses have not been fully elucidated. This thesis will focus on examining how the presence of components from foreign pathogens, e.g. viral or bacterial infection, can …
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Post transplant lymphoproliferative disoders in liver transplant recipients : cases at Red Cross Children's Hospital Cape Town
… Children's Hospital. In 46% of these cases, viral infections resulted in considerable morbidity and mortality. Included in this group were: de novo hepatitis B (5 patients, 2 deaths), EBV-related post-transplantation lymphoproliferative disease (6 patients, 4 deaths) and CMV disease (9 …
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Identification and characterisation of a novel gene, DWNN, isolated from promoter-trapped Chinese hamster ovary cells
… to the defence of the organism against viral infections. Defects in this process can lead to various autoimmune diseases and cancer. The aim of this study was to identify more genes involved in the cell death pathway and to link CTL killing, apoptosis and cancer.
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Discovery of Unique Antiviral Pathways in a Bat Viral Reservoir, the Black Flying Fox
Bats are asymptomatic reservoirs for a number of viral pathogens. How they manage to host highly pathogenic viruses such a Nipah and Marburg without showing clinical symptoms remains unclear. One of the earliest defenses vertebrates use to control viral infections is the interferon response. Upon …
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Interplay of Antibody Responses to Closely Related Viruses and Autoimmunity
… contribute to autoimmune disease. While pathogen infections have been associated with development of autoimmune diseases, the precise contributions of viral infections to autoimmunity remain elusive. The presence of autoreactive antibodies is associated with an increased risk of developing …
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Η ΑΝΤΙΙΚΗ ΔΡΑΣΗ IN VITRO ΠΑΡΑΓΟΜΕΝΩΝ ΙΝΤΕΡΦΕΡΟΝΩΝ ΣΕ ΣΧΕΣΗ ΜΕ ΤΑ ΣΥΣΤΗΜΑΤΑ ΜΕΤΡΗΣΗΣ - ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΑΝΙΧΝΕΥΣΗ IN VIVO ΠΑΡΑΓΟΜΕΝΩΝ ΙΝΤΕΡΦΕΡΟΝΩΝ
… IN VIVO IN HUMAN SERUM OF INDIVIDUALS WITH VIRAL INFECTIONS OF RESPIRATORY TRACT. THESE FACTORS WERE INVOLVED IN IFN-PRODUCTION (PRODUCER CELL AND INDUCER VIRUS) OF THE INDUCED TYPE OF IFN. FROM THE RESULTS WAS INDICATED THAT IFN PRODUCTION, IFN-ASSAY AS WELL IFN DETECTION IN HUMAN SERA …
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Molecular Mechanism of MDA5 RNA Sensing in Innate Immunity and Disease Pathogenesis
… a crucial role in recognising and combating viral infections. Double-stranded RNA (dsRNA) is a potent proinflammatory signal, and its recognition by MDA5 and its coregulatory factor, LGP2, is essential for initiating antiviral responses. This study aimed to investigate the structure and …
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The role of viral sequences in genetic aberrations and malignant transformation
Cancer is a leading cause of death worldwide and viral infections such as HBV/HCV and HPV have been known to be responsible for up to 20% of cancers in low- and middle-income countries. Approximately 500,000 of these deaths are due to oesophageal squamous cell carcinoma (OSSC) alone, one of the …
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