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Showing 1 to 4 of 4 for “"viral hemorrhagic fevers"”.
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Countermeasures Against Viral Hemorrhagic Fevers
Viral hemorrhagic fevers (VHFs) are a group of viruses from four different virus families that are characterized by coagulation abnormalities with often fatal outcomes. VHFs can cause both internal and external bleeding. The virus families include: Filoviridae, Arenaviridae, Bunyaviridae, and …
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Investigations into endothelial cell permeability and adherens junction disruption induced by Junín virus infection.
… Junín is the causative agent of Argentine hemorrhagic fever (AHF) characterized by vascular dysfunction and fluid distribution abnormalities. Clinical, as well as experimental studies, have implicated involvement of the endothelium in pathogenesis of AHF, although the role it may play is …
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Using the host immune response to hemorrhagic fever Viruses to understand pathogenesis and improve diagnostics
Hemorrhagic fever viruses cause severe infections characterized by a hyperactive immune response that often leads to multiorgan failure and death. Current diagnostic tests are based on detecting viral proteins and nucleic acids in the blood. These are late-stage events during infection, which makes …
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Arenavirus Attenuation Mechanisms
… Junín virus, the etiological agent of Argentine hemorrhagic fever (AHF), causes up to 30% mortality in humans and is considered a National Institute of Allergy and Infectious Disease (NIAID) Category A Pathogen (Charrel and de Lamballerie, 2003). AHF affects numerous Argentineans each year and …