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Showing 1 to 2 of 2 for “"viral genome delivery"”.
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Evading Innate and Adaptive Immunity During Adenovirus Cell Entry
… cells via clathrin-mediated endocytosis. For viral genome delivery to the nucleus, Ad must penetrate endosomal membranes to create defects sufficient for the passage of the 90 nm diameter capsid across cell membranes. Recent observations suggest that adenovirus type 5 (Ad5) capsid uncoating …
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A Role for Mindbomb 1 in Adenovirus Genome Delivery
… many of which must successfully deposit their genomes into the nucleus for replication. Viral capsids strategically navigate this vast distance (and all subsequent lifecycle steps) through the coordinated hijacking of a number of cellular proteins subsequently termed host factors. Given the …