Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"viral fusion"”.
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Heterotrimeric coiled-coils as viral fusion protein mimics
… incorporate trimeric coiled-coils in their fusion proteins, and, consequently, are involved in the pathway to infection. Through interactions at the electrostatic interfaces of the coiled-coils, these fusion proteins form a six-helix bundle called a trimer-of-hairpins. The formation of this …
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Solid-state NMR investigation of viral fusion glycoprotein 41 (gp41)
Protein-mediated membrane fusion is an integral part of numerous cellular processes and viral entry. The HIV envelope glycoprotein mediates viral entry into target cells by fusing the viral envelope with the cell membrane. This process requires large-scale and multi-step conformational changes of …
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On the role of conformational flexibility in viral fusion mechanisms - fusion by disorder
Viral diseases continue to contribute to leading causes of death around the world and are annually responsible for significant morbidity and mortality. Many envelope viruses infect cells through the use of fusion proteins, surface proteins which are responsible for fusing the viral and host …
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Characterization and Reconstitution of S-Palmitoylated IFITM3 Antiviral Activity
… These sensors recognize key components of viral, bacterial and fungal pathogens, and stimulate an inflammatory response which leads to the expression of an extensive network of host defense proteins. One such canonical network is regulated by type I interferon. This pathway responds to …
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The study of ancient viral class II envelope fusion proteins within the viral retroelements of Nematoda and the nuclear plasmids of Dictyostelium
… Bel/Pao LTR-retrotransposon encodes an ancient viral class II envelope fusion protein. Typically, retroviruses and related degenerate retrotransposons encode a hemagglutinin-like class I envelope fusion protein. A subset of Bel/Pao LTR-retrotransposons within the phylum Nematoda have acquired a …
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New approaches for the synthesis of unusual amino acids
… Protein-protein interactions are involved in viral fusion and so are promising targets for anti-viral drugs. Photoactivatable amino acids have been used to identify these interactions. Activation by ultraviolet light induces covalent cross-linking (known as photo cross-linking) of the …
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INNATE IMMUNITY IN ENCEPHALITIC BUNYAVIRUS INFECTION: OVERCOMING NEURONAL VULNERABILITY
… responses. Innate immunity, including the antiviral interferon (IFN) and inflammatory NF-κB pathways, coordinates host responses to pathogens. It is unclear whether neurons are able to detect RVFV and LACV and mount an effective antiviral response, as neurons have likely adapted to minimize …
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Proteins Inside Cells and On the Surface of Membranes: Developing Three Dimensional In-Cell NMR and Structural Characterization of a Trimeric Membrane Proximal External Region Construct from HIV-1 gp41
… the MPER might contribute to the mechanism of viral fusion by inducing strain in the viral membrane.</p>
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
… binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the GP-C complex, with emphasis on elucidating the role of SSP in arenavirus life cycle. We present genetic evidence that support the inclusion of G2 as a …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
… binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the GP-C complex, with emphasis on elucidating the role of SSP in arenavirus life cycle. We present genetic evidence that support the inclusion of G2 as a …
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USING SINGLE VIRION FUSION ASSAY TO STUDY INFLUENZA VIRUS ENTRY
… is critical for effectively developing anti-viral drugs and vaccines. The entry of influenza virus is mediated by two proteins: hemagglutinin (HA) and neuraminidase (NA). During virus infection, HA first binds to sialic acid moieties on epithelial cell membranes, triggering engulfment of the …
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Experimental and computational study of the mechanics of chikungunya
… of people in Africa. In Africa, viruses with a viral envelope, i.e. enveloped viruses, like HIV and influenza, cause thousands of deaths each year yet no cure exists. It has been proposed that the mechanical properties of enveloped viruses may play a role in viral entry into host cells. This …
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Development of an Assay to study the Kinetics of HIV-1 Capsid Uncoating
… Despite impressive developments in antiretroviral therapy, current medical intervention is unable to prevent or cure HIV-1 infection, necessitating expensive life-long treatment. Difficulties in establishing a vaccine or cure, arise from its capacity to cause life-long latent infection, and …
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Model membrane interactions with ions and peptides at the air/water interface
… across the blood-brain barrier and viral fusion processes. Alteration of peptide structure could be a cause of many diseases. Biological membranes are complex systems, therefore simplified models may be introduced in order to understand processes occurring in nature. The lipid …
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Contribution of the Membrane-Proximal Region of the Vesicular Stomatitis Virus Glycoprotein to Host Cell Entry and Membrane Fusion
… VSV has been used as the prototype to study viral entry, transcription, replication, and assembly. Viral entry, a critical step in the lifecycle of the virus, is mediated by the outer surface protein, G and will be the focus of this dissertation. </p> <p>We hypothesize that the highly …