Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"viral escape"”.
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A control theoretic approach to mitigate viral escape in HIV
… long asymptomatic period and a final increase in viral load with a simultaneous collapse in healthy CD4+T cell count during which AIDS appears. Motivated by the worldwide impact of HIV infection on health and the difficulties to test in vivo or in vitro the different hypothesis which help us to …
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Language Models Predict Drug Resistance from Complex Sequence Variation
… barrier to the development of vaccines, antiviral drugs, and antibiotics. Recently, neural language models trained on viral protein sequence evolution have shown promise in their ability to predict viral escape mutations, potentially enabling more intelligent therapeutic design [6]. Hie et …
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Therapeutic Uses of Broadly Neutralizing Anti-HIV-1 Antibodies in Humanized Mice
<p>Combination anti-retroviral drug therapy (ART) significantly suppresses HIV-1 viremia in most infected individuals, but is incapable of curing disease. The major barrier to HIV-1 cure is a population of long-lived cells that harbor replication-competent provirus and are refractory to current …
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Learning from pre-pandemic data to forecast viral antibody escape
… pandemic preparedness relies on anticipating viral mutations that are able to evade host immune responses in order to facilitate vaccine and therapeutic design. However, current strategies for viral evolution prediction are not available early in a pandemic – experimental approaches require …
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Mechanisms and Genetic Determinants of Alphavirus Infection of Mosquito Vectors
… and their vector indicate that the primary viral determinants for successful infection of epizootic mosquito vector can be mapped to the E2 glycoprotein region. I hypothesized that in addition to the E2 glycoprotein, regions outside of the E2 glycoprotein determine successful infection by …
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Dissecting Human Antibody Responses Against Influenza A Viruses And Antigenic Changes That Facilitate Immune Escape
… pre-existing antibodies, allowing the virus to escape population immunity in a process known as antigenic drift. Due to antigenic drift, individuals can be repeatedly infected by antigenically distinct influenza strains over the course of their life. Antigenic drift undermines the effectiveness …
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Phage host range and definition of genes implicated in Type III toxin-antitoxin-mediated abortive infection
Bacteria are under constant threat by their viral parasites, the bacteriophages (phages) and have evolved a range of anti-phage systems to defend themselves. One of these systems is termed abortive infection (Abi) where, upon phage infection, an Abi system may be activated which initiate a …
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Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection
… responses play a pivotal role in controlling viral replication during HCV infection. HCV evades the immune system by rapid viral evolution affording escape from immune selection pressure including at MHC-I restricted epitopes. However, some CTL epitopes remain conserved well past the time of …
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Interactions Between APOBEC3 and Murine Retroviruses: Mechanisms of Restriction and Drug Resistance
APOBEC3 proteins are important for antiretroviral defense in mammals. The activity of these factors has been well characterized in vitro, identifying cytidine deamination as an active source of viral restriction leading to hypermutation of viral DNA synthesized during reverse transcription. These …
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The identification of cytotoxic T lymphocyte (CTL) escape in a large, longitudinal subtype C HIV-1 sequence dataset
Human Immunodeficiency Virus (HIV) rapidly escapes cytotoxic T-cell lymphocyte (CTL) immune responses exerted by the host. Mutation patterns and HLA associated footprints linked to viral escape have been identified, making it possible to use viral sequence data, combined with the host HLA allele …
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Stochastic processes in T-cell signaling
… hypotheses. 3. While rare events, such as escapes from stable basins, take a long time (waiting time) to occur, they take little time to complete once they have started. We showed that for Markov processes characterized by detailed balance, successful transitions, on average, complete …
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Recall Germinal Center and Antibody Responses
… epitopes, thus enabling tailored targeting of viral escape epitopes. Our findings have implications for the understanding of OAS and for the design and testing of vaccines against evolving pathogens.</p>
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A study of immune responses during antiviral treatment for hepatitis C virus infection
… of HCV specific T cell responses caused by viral escape and T cell exhaustion considered to be mediated by constant antigen stimulation. Hepatitis C virus has developed strategies to escape innate immune responses leading to chronic infection in the face of ongoing innate immune activity. …
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The impact of neutralizing antibody and ADCC responses on HIV-1 envelope evolution in early infection
… with the primer ID method which barcodes each viral genome, enabled us to generate thousands of viral sequences to accurately track viral population dynamics in early infection. In all participants investigated, there was a significant drop in the relative frequency of wildtype (WT) virus …