Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"viral dynamics"”.
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Dissecting the Contribution of the Carboxyl-Terminal Domain and Tail of HIV-1 Integrase to Viral Dynamics and Enzymatic Function
… Deficiency Syndrome (AIDS). Combination antiviral therapy has proven to be particularly effective at suppressing viral replication, yet complete eradication of the virus from an infected individual remains elusive. Recently, a new class of antiviral drugs targeting the viral integrase (IN) …
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Modeling HIV-1 Infection in the Brain: The Effect of the Blood-Brain Barrier
Despite the advancement of antiretroviral therapy (ART), the development of HIV associated neurocognitive disorders (HAND) remains a major concern among HIV infected patients. As many ART drugs may fail to penetrate the blood-brain barrier (BBB), the long-term presence of viral RNA in the brain is …
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Mathematical modelling of host-disease-drug interactions in HIV disease
… aim at achieving and maintaining a low viral burden and typically involve multiple drugs. The choice of optimal combinations of these drugs is crucial, particularly in the background of treatment failure having occurred previously with certain other drugs. An understanding of the …
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Mathematical Models of Immune Responses to Infectious Diseases
… HIV and HPV co-infection, ii) A germinal center dynamics model, iii) A study of monoclonal antibody therapy. We predict that the condition leading to HPV persistence during HIV/HPV co-infection is the permissive immune environment created by HIV, rather than the direct HIV/HPV interaction. In the …
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In silico vaccine design for hepatitis C: A computational platform for fighting disease
… physics, Bayesian inference, population dynamics, and high-performance computing to define empirical fitness landscapes and conduct viral dynamics simulations to determine vulnerable viral targets and rationally design vaccine immunogens. This computational design protocol will guide and …
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Spillover and emergence of bat-origin viral infections
… research to quantify and characterise the system dynamics of bat-origin viral emergence events. Chapters 2–5 are comprised of four quantitative analyses: a compartmental model comparison of stochastic henipavirus serological dynamics in captive bats (Eidolon helvum in Ghana), a quantitative …
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Efficacy of Antibody and T cell Therapies for Highly Mutable Viruses like Human Immunodeficiency
… we develop a stochastic computational model of viral dynamics to help characterize the regimes where viral control or cure may be possible. We study the efficacy of either bnAb therapy or therapeutic vaccination that elicits T cell responses that target mutationally-constrained regions, as well …
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Scaling in the immune system
… It is not known how rates of immune response and viral dynamics vary from species to species and how they depend on species body size. Metabolic scaling theory predicts that intracellular processes are slower in larger animals since cellular metabolic rates are slower. We test how rates of …
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Development And Validation Of Novel Transmitted/founder Shivs For Hiv-1 Persistence And Cure Research
… at Env residue 375 that confers consistent early viral kinetics in RM, although longitudinal kinetics are more variable. Further, TF SHIVs have not been evaluated for their suitability for HIV latency and cure research. For my first aim, I evaluated two promising TF SHIVs, SHIV.191859 and …
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Why Pass On Fashion Viral Message? The Moderating Role of Consumers’ Fashion Traits, Message Traits and Individual Dynamics Traits in Social Media
Social media is being used as platforms for viral marketing. Although there is some evidence on the usefulness of viral marketing from the marketers’ perspective, little is known about the motivations, attitudes, and behaviors of consumers engaged in this marketing instrument. As the social media …
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Evaluating pooled testing designs in community and healthcare settings for infectious disease management and in particular for epidemics
… the population (such as compliance) and disease dynamics that best suit pooled testing, and 3) designing new pooled testing policies fit for purpose for the contexts studied. To perform these analyses, systematic simulation frameworks are developed. One important aspect that the frameworks …
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Within-host population dynamics and collective interactions of SARS-CoV-2 and influenza virus
Viral populations are comprised of an ever-diversifying assortment of individuals. This diversity can be observed from the global scale down to the most granular levels of infection, where genetically distinct viral genomes interact within a cell. Because every virus that circulates within a host …
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Drivers of Dengue Within-Host Dynamics and Virulence Evolution
… statistically fit these mathematical models to viral load data of dengue patients to understand the mechanisms that drive variation in viral load. I specifically consider the roles that immune status, clinical disease manifestation, and serotype may play in explaining viral load variation …