Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"viral RNA polymerase"”.
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RNA replication by poliovirus RNA-dependent RNA polymerase: effects of residue 5 on elongation complex stability and processivity
The poliovirus (PV) RNA-dependent RNA polymerase (RdRP) is a small, single-subunit, enzyme that is responsible for the replication of the viral genome. PV genome replication is much more involved than just repetitively incorporating a single nucleotide into an oligonucleotide primer. The polymerase …
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Investigating the mechanisms behind the immunostimulatory activity of influenza A virus RNA polymerase mutations
… essential for the development of protective antiviral responses. However, uncontrolled release of proinflammatory cytokines is also associated with severe and fatal disease caused by highly pathogenic avian and pandemic IAV strains. IAV infections are primarily detected by the retinoic …
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The Diversion of Macromolecular Synthesis in L-Cells Towards Ends Dictated by Mengovirus
… last few years. In the case of the details of viral nucleic acid metabolism, the pioneering work of S.S. Cohen and A. Kornberg and the many studies which followed on bacterial viruses have provided much knowledge about the enzymes involved in bacteriophage multiplication and the physiological …
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Poliovirus Replication: Interactions with Cytoplasmic Membranes and with Compounds Which Affect Virus Biosynthesis
<p>Picornavirus multiplication is intimately associated with intracellular membranes and affects their production and distribution within the cell. We have shown that the density distribution of cytoplasmic membranes separated by isopycnic centrifugation in discontinuous sucrose gradients is …