Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 152 for “"viral RNA"”.
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In Vitro Studies of Viral Rna Replication
Made available in DSpace on 2014-12-09T22:04:17Z (GMT). No. of bitstreams: 1 6801824.pdf: 3616523 bytes, checksum: f87239971fd149ef4b618b9ef8e9fae3 (MD5) Previous issue date: 1967
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Darwinian Selection Experiment With Q Beta Viral Rna
Made available in DSpace on 2015-05-13T22:12:02Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 6910797.PDF: 3602494 bytes, checksum: 45bc646954f82f571e545bf723cd4190 (MD5) Previous issue date: 1968
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Studies of the Intermediates in Viral Rna Replication
Made available in DSpace on 2014-12-09T22:04:19Z (GMT). No. of bitstreams: 1 6910730.pdf: 3631190 bytes, checksum: 2f37bfb90a50d0ceecba65806ad9e004 (MD5) Previous issue date: 1968
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Single molecule pull-down of viral RNA-protein complexes
Protein and RNA molecules interact with multiple protein partners to perform essential cellular processes such as post-transcriptional regulation of mRNA. Recently, a single molecule pull-down (SiMPull) assay was developed to isolate and study single protein complexes directly from cell lysates. …
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In Vitro Experiments on the Specificity of Viral Rna Replication
Made available in DSpace on 2014-12-11T00:00:12Z (GMT). No. of bitstreams: 1 7105170.pdf: 5614570 bytes, checksum: 5c746d2e25ba9a02fe30c4d5d6023bb8 (MD5) Previous issue date: 1970
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Methods toward investigating viral RNA capping enzymes and antibody breadth expansion
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Modulation of West Nile Virus Capsid Protein and Viral RNA Interaction through Phosphorylation
… aims to characterize the interaction between WNV viral RNA and the capsid (C) protein and also elucidate how the processes of nucleocapsid assembly are regulated. Initial in vitro C protein and viral RNA interaction studies showed that this interaction was not specific. This suggested the presence …
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Aptamer-based sequence verification platform for rapid multiplexed detection of viral RNA targets
… signal readout, and sensitivity, expose gaps in viral surveillance. To address these limitations, we have developed a novel Point-of-Care aligned method for the rapid isothermal amplification of viral RNA targets using RT-LAMP, and amplicon sequence verification using an aptamer-based …
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The Evolution of the Viral RNA Sensor OAS1 in Old World Monkeys and Cetartiodactyls
… environment poised to detect and respond to viral infection. The oligoadenylate synthetase family of enzymes comprises a crucial part of this innate immune response, directly signaling endonuclease activity responsible for inhibiting viral replication. Oligoadenylate synthetase 1 plays a …
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Crystal structure and functional studies of a viral RNA pseudoknot involved in ribosomal frameshifting
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1999.
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Antiviral activity of 3D8 single chain Fv against RNA virus infection
… in preventive or therapeutic fields to target viral antigens effectively. 3D8 is an anti-DNA catalytic antibody that binds to DNA and RNA then degrades them without sequence specificity as well known as Abzymes. Previously it was reported that 3D8 single chain variable fragment (scFv) has …
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Molecular characterization and nucleotide sequence of the coat protein gene of the NL-3 strain of bean common mosaic virus
… The NL-3 strain of the virus was purified and viral RNA extracted. Complementary DNA was synthesized from the viral RNA using Moloney-murine leukemia reverse transcriptase and Xho I oligo-dT priming. The single-stranded cDNA was converted into ds DNA by DNA polymerase and directionally cloned …
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Development of a Mouse Model of NY99 West Nile Virus-Induced Neurological Changes
… inflammatory changes after infection, and if the viral RNA persisted in the brain. Mice infected with WNV that were euthanized over one month post-infection tended to perform worse than uninfected mice on memory testing, and had persistent inflammatory lesions and viral RNA in multiple brain …
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Electron microscopic studies on barley yellow dwarf virus infection in oats
… The virus is transmitted by aphids that inject viral particles into the phloem of the host during the feeding process. BYDVs remain restricted to the phloem tissue and cause cytopathological alterations that ultimately lead to complete obliteration of the infected cell. Phloem cells are …
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Method development in chemical and biological selection platforms Part one: Reaction mining: A platform for the discovery of novel chemical reactivity Part two: Synthetic platforms for the characterization and targeting of viral RNA-capping enzymes
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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CHARACTERIZATION OF INFLUENZA NUCLEOPROTEIN BODY DOMAIN AS ANTIVIRAL TARGET
<p>Influenza is a segmented negative strand RNA virus. Each RNA segment is encapsulated by viral nucleoprotein (NP) and bound by the viral RNA dependent RNA polymerase (RdRP) to form viral ribonucleoproteins (vRNPs) responsible for RNA synthesis. NP is a structural component of the vRNP but also …
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Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
… secretes similar levels of infectious virus and viral RNA than WA1-infected cells but produces higher levels of intracellular viral RNA than WA1 and outcompetes parental WA1 in a competition experiment. Lastly, ΔSGF-WA1 infected mice have higher levels of viral RNA than WA1-infected mice and …
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Techniques of RNA Isolation and Characterization in Infectious Pancreatic Necrosis Virus-Infected Chinook Salmon Embryo Cells
… making it the most economically devastating viral disease for fish hatcheries. This prototype naked, double-stranded RNA virus of the Birnaviradae family was studied to test new techniques for isolation and characterization of its ambiguous early post-infection viral RNA products. RNA was …
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Mechanisms of retroviral replication
Specific encapsidation of viral RNA is an essential step of retroviral replication cycle. Extensive biochemical and genetic analyses suggest that majority of retroviruses employ similar mechanisms for specific RNA packaging. Better understanding of mechanisms of this process may help to develop new …
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In vitro inhibition of coronavirus replications
… Replications A search for new anti-coronaviral drugs to treat coronaviral infections was motivated by an outbreak of severe acute respiratory syndrome (SARS). In order to find drugs that treat coronavirus infections, including SARS, we screened traditional medicinal herbal extracts and …
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