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Showing 1 to 12 of 12 for “"vinylation"”.
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Synthesis, Vinylation and Rearrangement of NH-Isoxazolines and Copper Catalyzed 6 Pi Electrocyclization
Enaminones are a privileged motif that have both nucleophilic and electrophilic reactivity embedded within. Finding new ways to access these compounds is of high interest. The Anderson group is interested in utilizing [3,3] sigmatropic rearrangements to access new N-heterocycles in …
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Studies on the 1-Aza-1 Prime -Oxa-(3,3)-Sigmatropic Rearrangement: Synthesis of Ortho-(beta-Oxoalkyl) Anilides and Regiospecifically Substituted Indoles
… substituent resulting from the O-vinylation of the hydroxamic acid and {3,3}-sigmatropic rearrangement.
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Oxidative Heck Reactions with Terminal Olefins
… mild and selective synthetic methods. The Heck vinylation uses orthogonally reactive C-H bonds and these bonds are often easy to carry through synthetic sequences. Despite this advantage, the synthetic potential of the intermolecular Heck reaction has not been realized in complex molecule …
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Total synthesis and study of myrmicarin alkaloids
… include a stereospecific palladium-catalyzed N-vinylation of a pyrrole with a vinyl triflate, a copper-catalyzed enantioselective conjugate reduction of a P-pyrrolyl enoate, and a regioselective Friedel-Crafts reaction. The synthesis of optically active and isomerically pure samples of …
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Total Synthesis of the 2-Nitropyrrole Natural Product Heronapyrrole C
… of the key intermediate, alkene 294, by a vinylation of iodide 299 with a suitable vinyl organometallic species (300). The iodide coupling partner 299 was successfully synthesised from 2-nitropyrrole 144. A successful model reaction between iodide 299 and vinyltributyltin indicated the …
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Zincative Functionalization of C–H Bonds Using Lithium Amide Zincate Bases
… allylation and copper-catalyzed arylation and vinylation with aryl iodides and vinyl iodides. In summary, lithium zincate bases have been demonstrated to be broadly useful for diverse and regioselective C–H functionalization to introduce valuable complexity from simple starting materials.</p>
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1,2,3-triazoles as X-factor in gold(I) activation of challenging C-C triple bond transformations
… have been developed such as arylation, vinylation, propargylation and allenation. Besides the new methods are benefiting the field related to triazole functionalization, new reactivity of ligand-metal complexes was revealed.;A series of 1,2,3-triazole gold complexes were …
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The Interplay Between Anions And Radicals In Synthesis, Spectroscopy, And Catalysis
… proposed mechanisms; however, the mechanism of vinylation was evidently more complicated than previously proposed. Next, our successful synthesis and isolation of a compound containing a CeIV–Caryl bond enabled the investigation of the complex by 13C NMR and computation. These studies determined …
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New lithiation methodologies to 2-substituted nitrogen heterocycles
… Additionally, a protocol for the lithiation-vinylation of N-Boc pyrrolidine is developed and used to carry out the first asymmetric synthesis of (R)-maackiamine. Chapter 5 details the development of a new diamine-free racemic lithiation procedure for the lithiation-trapping and …
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Lignin acrylate derivatives and their behaviors in free radical copolymerizations
… lignins and hydroxypropyl lignins to study their vinylation and copolymerization behaviors. Lignin model compounds and lignin were subjected to reaction with isocyanatoethyl methacrylate (IEM) using dibutyltin dilaurate as catalyst. The acrylate derivatives were characterized by elemental …
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Selective C—H oxidations for complex molecule synthesis and diversification
… A highly selective intermolecular oxidative Heck vinylation is also described that forms di- and polyenes from simple α-olefins. Notably the Heck reaction requires only one pre-activated coupling partner. While traditional intermolecular Heck reactions are generally limited to resonance-activated …
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Nitrogen-Oxidants Enable Group-Transfer Reactions
… deuteration, allylation, and vinylation to generate molecular diversity from a common intermediate. Building on this foundation, Chapter five documents a photoredox-mediated method to generate the requisite sulfamyl radicals for site-selective carbon-carbon and carbon-oxygen …