Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"villin"”.
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Tyrosine Phosphorylation of Villin: Effects on Actin Dynamics, Cell Morphology and Cell Migration
… that an epithelial cell actin-binding protein, villin, plays a crucial role in the process of cell migration. Overexpression of villin in doxycyline-regulated HeLa Tet-off and MDCK Tet-off cells enhanced cell migration. We further demonstrate that tyrosine phosphorylation of villin by c-src is …
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The Modulating Effects of Dietary Fiber and Short-Chain Fatty Acids on Enterocyte Differentiation, Maturation and Turkey Coronavirus Infection
… was developed to determine relative levels of villin expression in turkey embryos. Villin is an actin-bound cytoskeletal protein known to be expressed in increasing quantities at the apical surfaces of maturing enterocytes. Villin expression level was found to increase linearly as a function of …
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Giardia Cathepsins and Their Role in Intestinal Disease
… proteases cleaved and disrupted cytoskeletal villin. This disruption of villin was sustained over time, at least in part, by host MLCK. Overall, this study establishes a reliable model for studying roles of parasitic cysteine proteases during host-parasite interactions. Further understanding …
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Charakterisierung des Zytoskelett-Proteins Villidin und einer dritten Profilin-Isoform in Dictyostelium discoideum
… villidin can be assigned to the gelsolin/villin-family as well as to the WD-repeat family. In principal, the group of the WD-repeat proteins includes regulatory proteins which are involved in signal transduction and other important cellular processes. The N-terminus of villidin harbours …
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Analysis of Molecular Dynamics Simulations of Protein Folding
… capabilities of nMDS by analyzing three complete villin headpiece folding and six norleucine mutant (NLE) folding trajectories simulated by Freddolino and Schulten [1]. Using these trajectories, I make comparisons between nMDS, PCA and clustering to demonstrate the superiority of nMDS. The three …
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Insights Into the Development of Gastrointestinal Brunner's Glands: Critical Stem Cells and Differentiation Factors
… used in order to test for the contribution of Villin to the formation of the Brunner’s Gland, and this is another intestinal marker important for differentiation. Our results showed that Brunner’s Glands do not express Villin. In addition, since Brunner’s Glands are secretory glands, we …
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Studies on Expression and Function of Vsig1 Gene
… Maus sowie der transgenen Cyto-und Vsig1 Villin-Vsig1 Maus. Expressionsanalysen zeigen, dass Vsig1 zwei alternative mRNA-Varianten transkribiert: das 2,4-kb lange Vsig1A und das 1,6-kb lange Vsig1B. Die Vsig1A Transkript wird durch Sequenzen die in der 5 'flankierenden Region des Exon1a …
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Application of All-Atom and Coarse-Grained Molecular Dynamics Simulations to Long Timescale Structural Transitions of Proteins
… the folding process of the WW domain and villin headpiece, the assembly and stability of a variety of viral capsids, the assembly and disassembly of high density lipoprotein particles, and the rotation of the bacterial flagellum. In each case, molecular dynamics simulations provided …
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Stromal Fibroblasts Restrain The Rate of Colon Cancer Progression and Metastasis By Suppressing Regulatory T Cells and Colon Cancer Stem Cells
… cancer model, which consists of 6 alleles: Villin-Cre-ERT2; APCflox/flox; p53flox/flox; tetO-LSL-KrasG12D; Rosa26-LSL-Luc; Rosa26-LSL-rtTA- eGFP. These mice were bred with αSMA-TK and αSMA-RFP transgenic mice for selective targeting and monitoring of myofibroblasts in the tumor …
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Non-Canonical Roles of Cytosolic Phosphoenolpyruvate Carboxykinase in Small Intestine Metabolism
… existing models to produce Pck1ff and Pck1ff+Villin-cre+/-, named Small Intestine PEPCK Knockout (SIPKO). Intestinal metabolism was evaluated in vivo and in vitro with respect to glucose, triglycerides, amino acids, and TCA cycle metabolism using a novel everted intestine perfusion model, …
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Vitras, Proteomizer, GhostBuster - A journey from Wet Lab to Machine Learning and back, pursuing Parkinson’s Disease
… overexpresses human 1-120 truncated αS under the villin promoter. I showed that, unexpectedly, the Vitras also expresses αS in the olfactory system, and specifically in the vomeronasal organ; from there, the protein travels to the first synaptic station, that is the accessory olfactory bulb, but …