Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"villin"”.
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Tyrosine Phosphorylation of Villin: Effects on Actin Dynamics, Cell Morphology and Cell Migration
… that an epithelial cell actin-binding protein, villin, plays a crucial role in the process of cell migration. Overexpression of villin in doxycyline-regulated HeLa Tet-off and MDCK Tet-off cells enhanced cell migration. We further demonstrate that tyrosine phosphorylation of villin by c-src is …
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The Modulating Effects of Dietary Fiber and Short-Chain Fatty Acids on Enterocyte Differentiation, Maturation and Turkey Coronavirus Infection
… was developed to determine relative levels of villin expression in turkey embryos. Villin is an actin-bound cytoskeletal protein known to be expressed in increasing quantities at the apical surfaces of maturing enterocytes. Villin expression level was found to increase linearly as a function of …
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Giardia Cathepsins and Their Role in Intestinal Disease
… proteases cleaved and disrupted cytoskeletal villin. This disruption of villin was sustained over time, at least in part, by host MLCK. Overall, this study establishes a reliable model for studying roles of parasitic cysteine proteases during host-parasite interactions. Further understanding …
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Charakterisierung des Zytoskelett-Proteins Villidin und einer dritten Profilin-Isoform in Dictyostelium discoideum
… villidin can be assigned to the gelsolin/villin-family as well as to the WD-repeat family. In principal, the group of the WD-repeat proteins includes regulatory proteins which are involved in signal transduction and other important cellular processes. The N-terminus of villidin harbours …
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Analysis of Molecular Dynamics Simulations of Protein Folding
… capabilities of nMDS by analyzing three complete villin headpiece folding and six norleucine mutant (NLE) folding trajectories simulated by Freddolino and Schulten [1]. Using these trajectories, I make comparisons between nMDS, PCA and clustering to demonstrate the superiority of nMDS. The three …
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Studies on Expression and Function of Vsig1 Gene
… Maus sowie der transgenen Cyto-und Vsig1 Villin-Vsig1 Maus. Expressionsanalysen zeigen, dass Vsig1 zwei alternative mRNA-Varianten transkribiert: das 2,4-kb lange Vsig1A und das 1,6-kb lange Vsig1B. Die Vsig1A Transkript wird durch Sequenzen die in der 5 'flankierenden Region des Exon1a …
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Application of All-Atom and Coarse-Grained Molecular Dynamics Simulations to Long Timescale Structural Transitions of Proteins
… the folding process of the WW domain and villin headpiece, the assembly and stability of a variety of viral capsids, the assembly and disassembly of high density lipoprotein particles, and the rotation of the bacterial flagellum. In each case, molecular dynamics simulations provided …
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Stromal Fibroblasts Restrain The Rate of Colon Cancer Progression and Metastasis By Suppressing Regulatory T Cells and Colon Cancer Stem Cells
… cancer model, which consists of 6 alleles: Villin-Cre-ERT2; APCflox/flox; p53flox/flox; tetO-LSL-KrasG12D; Rosa26-LSL-Luc; Rosa26-LSL-rtTA- eGFP. These mice were bred with αSMA-TK and αSMA-RFP transgenic mice for selective targeting and monitoring of myofibroblasts in the tumor …
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Non-Canonical Roles of Cytosolic Phosphoenolpyruvate Carboxykinase in Small Intestine Metabolism
… existing models to produce Pck1ff and Pck1ff+Villin-cre+/-, named Small Intestine PEPCK Knockout (SIPKO). Intestinal metabolism was evaluated in vivo and in vitro with respect to glucose, triglycerides, amino acids, and TCA cycle metabolism using a novel everted intestine perfusion model, …
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Vitras, Proteomizer, GhostBuster - A journey from Wet Lab to Machine Learning and back, pursuing Parkinson’s Disease
… overexpresses human 1-120 truncated αS under the villin promoter. I showed that, unexpectedly, the Vitras also expresses αS in the olfactory system, and specifically in the vomeronasal organ; from there, the protein travels to the first synaptic station, that is the accessory olfactory bulb, but …