Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"vesicular monoamine transporter"”.
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MUTATION OF THE VESICULAR MONOAMINE TRANSPORTER-1 GENE ALTERS ITS PROTEIN PRODUCT
The vesicular monoamine transporter 1 (VMAT1) is essential for storage of monoamines, such as epinephrine and serotonin, in secretory vesicles of neuroendocrine cells. Recently the VMAT1 protein was detected in human and mouse brain, and mutations of the VMAT1 gene at single DNA nucleotides (single …
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Characterization of Vesicular Monoamine Transporter 2 and Its Role In Parkinson'S Disease Pathogenesis Using Drosophila
… to play a role in selective neuronal loss in PD. Vesicular Monoamine Transporter (VMAT) is essential for proper vesicular storage of monoamines such as DA and their regulated release. Increasing evidence have linked VMAT dysfunction with Parkinson’s disease. In this study, we re-examine the gain- …
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FUNCTIONAL AND BIOCHEMICAL CONSEQUENCES OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE HUMAN VESICULAR MONOAMINE TRANSPORTER 1 GENE (SLC18A1) By Sally Gamal Shukry, B.S.
… OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE HUMAN VESICULAR MONOAMINE TRANSPORTER 1 GENE (SLC18A1) By Sally Gamal Shukry, B.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Biology at Virginia Commonwealth University. Virginia Commonwealth …
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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
… and Pb-exposed mice were immunostained for the vesicular monoamine transporter 2 (VMAT2), serotonin, and dopamine beta hydroxylase (DβH, a marker for norepinephrine) in order to elucidate the effect of Pb on monoaminergic input into the SOC. In addition, sections were immunolabeled with …
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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
… and Pb-exposed mice were immunostained for the vesicular monoamine transporter 2 (VMAT2), serotonin, and dopamine beta hydroxylase (DβH, a marker for norepinephrine) in order to elucidate the effect of Pb on monoaminergic input into the SOC. In addition, sections were immunolabeled with …
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Platelet Dense Granules Mature Within Late Stages Of Megakaryocyte Differentiation By Cargo Delivery
… addresses the putative DG transmembrane protein vesicular monoamine transporter 2 (VMAT2) and its localization throughout MK differentiation. VMAT2 has been implicated as the transporter responsible for serotonin uptake into DGs and is therefore a likely candidate for a DG protein. Within MKs, …
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The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
… in nature. MDMA initially causes synaptic monoamine release, primarily of serotonin (5-HT), producing hyperthermia and hyperactivity (5-HT syndrome). Conversely, the long-term effects of MDMA manifest as a prolonged depletion in 5-HT, and structural damage to serotonergic nerve terminals. …
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The nongenomic effects of physiological and environmental estrogens on dopamine transporter function
… regulatory machinery such as the dopamine transporter (DAT). In this dissertation we tested the rapid nongenomic effects of several physiological estrogens [estradiol (E2) estrone (E1), and estriol (E3)] and xenoestrogens (XEs), such as organochlorine pesticides [dieldrin, endosulfan, and …
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Analysis Of The Role Of Amphetamine In The Induction Of Changes In Histone Modifications Of Dopaminergic Pathway Genes
… regulates the expression of dat-1, the dopamine transporter and cat-1, vesicular monoamine transporter by reducing the enrichment of tri-methylated H3K4. Amphetamine treatment also increases the expression of cat-2, tyrosine hydroxylase by reducing the enrichment of tri-methylated H3K27.Our …
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I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission
… of fluorescent optical tracers of monoamine neurotransmitters for use in the study of monoamine transporter activity and distribution, as well as synaptic transmission in the brain. The second section details early studies concerning experimental therapeutics recently identified by …
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Neuropharmacological Properties of the Histaminergic System in the Zebrafish
… second study, pharmacological inhibition of the vesicular monoamine transporter 2 (VMAT2) was shown to result in an almost total loss of histamine immunoreactivity in neuronal fibres and a decreased number of histamine neurons. Additionally, levels of histamine and other amine neurotransmitters …
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Molecular and Neurochemical Effects of Methylphenidate on the Developing Brain
… effects of acute and chronic MPH treatment on monoaminergic protein markers, genes and their corresponding proteins involved in synaptic plasticity, as well as the drug’s effect on metabolic pathways. The investigations were conducted on brain regions implicated in the symptoms of ADHD in …
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Assoziationsstudien von Kandidatengenen (VMAT2, DAT, BDNF) mit Persönlichkeitsmerkmalen und psychiatrischen Erkrankungen
… Kandidatengene (vesikulärer Monoamintransporter VMAT2, Dopamintransporter DAT, Brain Derived Neurotrophic Factor BDNF) bei Persönlichkeitsmerkmalen und psychiatrischen Erkrankungen näher zu beleuchten. C. Robert Cloninger postuliert in seiner biosozialen Persönlichkeitstheorie eine …