Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"vesicular glutamate transporter"”.
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PHYSICO-CHEMICAL STUDIES OF THE VESICULAR GLUTAMATE TRANSPORTER 1 (VGLUT1)
The vesicular glutamate transporter 1 (VGLUT1) is an important membrane protein located in glutamatergic synaptic vesicles. It is responsible for the storage and release of the excitatory neurotransmitter glutamate. VGLUT1 is a highly hydrophobic integral membrane protein with a molecular weight …
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PHYSICO-CHEMICAL STUDIES OF THE VESICULAR GLUTAMATE TRANSPORTER 1 (VGLUT1)
The vesicular glutamate transporter 1 (VGLUT1) is an important membrane protein located in glutamatergic synaptic vesicles. It is responsible for the storage and release of the excitatory neurotransmitter glutamate. VGLUT1 is a highly hydrophobic integral membrane protein with a molecular weight …
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The vesicular glutamate transporter (VGLUT): heterologous expression, proteoliposome, computational and mass spectral studies
<P>Vesicular glutamate transporters (VGLUTs) are integral membrane proteins that uptake glutamate into synaptic vesicles and are involved in glutamatergic neurotransmission. Since VGLUTs were identified and cloned, efforts have been made to characterize their functional roles. However, due to …
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The vesicular glutamate transporter (VGLUT): heterologous expression, proteoliposome, computational and mass spectral studies
<P>Vesicular glutamate transporters (VGLUTs) are integral membrane proteins that uptake glutamate into synaptic vesicles and are involved in glutamatergic neurotransmission. Since VGLUTs were identified and cloned, efforts have been made to characterize their functional roles. However, due to …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
As the primary excitatory amino acid, glutamate is essential to proper functioning of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
As the primary excitatory amino acid, glutamate is essential to proper functioning of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the …
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The JBS-associated E3 Ligase UBR-1 Maintains Synaptic Glutamate Homeostasis and Regulates Neurotransmitter Balance
… I find that the absence of UBR-1 disrupts glutamate homeostasis, and further identified three components of a UBR-1-regulated signaling pathway - a glutamate metabolic enzyme GOT/GOT-1.2, a vesicular glutamate transporter VGlut3/EAT-4, and a glutamate-gated chloride channel GluCl/AVR-15 - …
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Effects of Neuronal Nogo-A on Properties of Excitatory Synapses of the Sensorimotor Cortex
… by regulating the maturation and stability of glutamatergic synaptic input. To examine the roles of Nogo-A at the excitatory synapse of the neocortex, we used RNAi directed against Nogo-A and delivered it to the developing rat sensorimotor cortex via AAV2/8, a neurotropic vector. This resulted …
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Spinal interneurons in sensorimotor integration
… terminals that were immunoreactive for the vesicular glutamate transporter 1 (VGLUT1) but those cells from the second group received few contacts of this type and were predominantly contacted by terminals immunoreactive for vesicular glutamate transporter 2 (VGLUT2). This result was as …
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Genetic Dissection of Synaptic Vesicle Endocytosis
… endocytosis, assessed by the trafficking of vesicular glutamate transporter fused to pHluorin, is unperturbed. Synaptic vesicle endocytosis in the absence of dynamin 2 was assessed at both room temperature and 32 oC. At both temperatures, my results reveal that synaptic vesicle recycling …
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Exploring Synaptic Vesicle Exocytosis
… variant of the green fluorescent protein and the vesicular glutamate transporter. This reporter is incorporated into synaptic vesicles and increases its fluorescence when those vesicles fuse with the presynaptic membrane. Using this reporter, we measure the size of the primed pool of vesicles (n), …
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The Role of the Serotonergic Neurotransmitter System in the Development and Treatment of Affective Disorders
… reduced social behaviors. Because the serotonin transporter, the target of these drugs, is expressed primarily in serotonergic neurons of the raphe, I sought to identify biological mechanisms for behavioral effects of both adult and postnatal SSRI treatment in this cell population. Initially, we …
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Unmasking Impulsivity as a Glutamatergic Dysfunction Phenomenon: Presynaptic and Postsynaptic Considerations
… (DA) and serotonin (5-HT) systems, however the glutamate (Glu) system, localized throughout the central nervous system and responsible for most excitatory signaling, has largely been left untouched. This is striking because like impulsivity, Glu is heavily involved in many neuropsychiatric …
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DEVELOPMENTAL REMODELING OF RELAY CELLS IN THE DORSAL LATERAL GENICULATE NUCLEUS (dLGN) OF THE MOUSE AND THE ROLE OF RETINAL INNERVATION
… RGC-specific presynaptic machinery in dLGN (e.g. vesicular glutamate transporter 2), and ultrastructural analysis at the electron microscopy level demonstrated that the dLGN is devoid of retinal innervation. We examined the functional and morphological characteristics of relay cells in WT and …
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Synaptic vesicle protein 2A-dependent function and dysfunction at the presynapse
… observed effects of the drug on synaptophysin, vesicular glutamate transporter 1 (VGLUT1) and SYT1 recycling were observed, suggesting that LEV is unlikely to function as a modulator of excitatory presynaptic activity or by influencing SV2A function. In conclusion, this work demonstrates that …
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Spinothalamic tract neurons in laminae I, III and IV of the rat: a retrograde neuronal tracing study
… and have a very high density of input from glutamatergic axons that contain vesicular glutamate transporter 2 (VGLUT2). These "large gephyrin-coated cells" in the lumbar cord are known to project to the LPb, but it is not yet known whether they project to thalamus and PAG. Therefore, another …
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CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse
… of rat brain that construct dopamine (DA) and glutamate (GLU) pathways such as ventral tegmental area (VTA), substantia nigra (SN), and nucleus accumbens (NAc). In the central nervous system (CNS), activation of CXCR4 on dopaminergic neurons and astrocytes initiate cascade of events that leads …