Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"vesicle recycling"”.
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Synaptic vesicle recycling <i>in Vivo</i>
… mit Neurotransmitter gefüllt, was als Vesikelrecycling bezeichnet wird. Überraschenderweise können Synapsen bis zu einer halben Millionen Vesikel enthalten, von denen die meisten in vielen Präparationen in vitro durch Hochfrequenz-Stimulierung zum Recycling angeregt werden können. Es ist …
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Developmental trajectory of synaptic vesicle recycling in wild type and neurodevelopmental disorder mqodels
… This is made possible by exocytosis of synaptic vesicles (SV) that package the neurotransmitters, and these SVs are recycled via endocytosis. However, the sequence of events through which a presynapse acquires functionality is relatively poorly understood, which is surprising since mutations in …
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MUNC13 PROTEINS REGULATE STRAIN-DEPENDENT EFFECTS OF ETHANOL-MEDIATED INHIBITION OF SYNAPTIC VESICLE RECYCLING
Alcoholism is a chronically relapsing disorder characterized by an inability to remain abstinent from alcohol for prolonged periods of time. One of the major factors contributing to relapse is the development of profound anxiety during abstinence. Our lab has previously demonstrated that chronic …
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Regulation of Synaptic Vesicle Trafficking at Central Synapses
… in the brain. At presynaptic terminals, synaptic vesicles fuse with plasma membrane in response to electrical stimulation, followed by rapid retrieval to the terminal and re-organization for reuse. Thus, synaptic vesicle trafficking is of interest as to where presynaptic regulations of synaptic …
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Genetic Dissection of Synaptic Vesicle Endocytosis
… through the fusion of discrete synaptic vesicles with the presynaptic membrane. To maintain reliable transmission, synaptic vesicles and proteins must be recycled after release of neurotransmitters. A key protein in this recycling process is dynamin. Dynamin is a GTPase that catalyzes the …
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Analysis of the Interaction and Functional Determinants of Arc and Its Regulation of Dynamin
… neuronal isoform required for rapid pre-synaptic vesicle recycling, but does not stimulate its activity or assembly. The Arc-dynamin interaction is strongly dependent on ionic strength and the polymerization state of dynamin, which Arc enhances. Consequently, biophysical studies were used to …
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Molecular Determinants of Synaptic Vesicle Exocytosis and Endocytosis Coupling
Synaptic vesicle recycling is essential for maintaining normal synaptic function. The reuse of vesicles maintains the size of the presynaptic terminal and ensures the availability of synaptic vesicles for subsequent exocytosis. The coupling of exocytosis and endocytosis allows for continued rapid …
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Characterisation of a novel Rab18 mouse model for Warburg Micro syndrome
… and identified no abnormalities in synaptic vesicle recycling and no atrophy of peripheral muscles or aberrant development or stability of neuromuscular connectivity. However, loss of RAB18 resulted in gross accumulations of neurofilament and microtubule proteins at the neuromuscular junction …
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Synaptojanin1 is involved in endolysosomal trafficking in cone photoreceptors
… of neurotransmitter and subsequent synaptic vesicle recycling. Although both ends of the photoreceptor require efficient membrane trafficking, the majority of studies of protein trafficking in photoreceptors have focused on the outer segment. In addition, photoreceptors do not need to degrade …
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Dissecting Synaptic Vesicle Endocytosis
<p>Synaptic vesicle endocytosis is critical for ensuring rapid local recycling of synaptic vesicles to enable ongoing neuronal activity. We utilized the sensitivity and robustness of the pHluorin assay of synaptic vesicle recycling to probe the control of endocytosis spatially and in response to …
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Studies of viral and cellular proteins involved in herpes simplex virus type-1 egress
… Nipsnap2 have been proposed to contribute in vesicle transport and membrane fusion in cells. Using CRISPR-Cas9 technology these proteins were knocked out in a keratinocyte cell line (HaCaT) to investigate their role in HSV-1 egress. However, little or no effect on HSV-1 egress could be …