Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 495 for “"vesicle"”.
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Exploring Synaptic Vesicle Exocytosis
… This reporter is incorporated into synaptic vesicles and increases its fluorescence when those vesicles fuse with the presynaptic membrane. Using this reporter, we measure the size of the primed pool of vesicles (n), a privileged subset of synaptic vesicles which are docked at the active zone …
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Dissecting Synaptic Vesicle Endocytosis
<p>Synaptic vesicle endocytosis is critical for ensuring rapid local recycling of synaptic vesicles to enable ongoing neuronal activity. We utilized the sensitivity and robustness of the pHluorin assay of synaptic vesicle recycling to probe the control of endocytosis spatially and in response to …
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Calcium Triggered Synaptic Vesicle Exocytosis
… in neuroscience is how Ca 2+ promotes synaptic vesicles from rest to fusion leading to release of neurotransmitters. In this thesis, I first addressed if synaptogmin-1/SNARE binding is important for synaptic vesicle release. Using two knock-in mouse lines each with single amino-acid …
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Genetic Dissection of Synaptic Vesicle Endocytosis
… through the fusion of discrete synaptic vesicles with the presynaptic membrane. To maintain reliable transmission, synaptic vesicles and proteins must be recycled after release of neurotransmitters. A key protein in this recycling process is dynamin. Dynamin is a GTPase that catalyzes the …
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Molecular Mechanisms Controlling Synaptic Vesicle Fusion
… fusion events occur immediately upon a vesicle interacting with its target membrane. But, in certain circumstances, such as in synaptic vesicles, spontaneous fusion is not desired, so a clamp protein is necessary to prevent this fusion until signaled to do otherwise. In synapses, this …
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A tensed pathway to vesicle clustering
Embargo set by: Seth Robbins for item 109802 Lift date: 2021-02-07T20:39:46Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system
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Extracellular Vesicle Capture and microRNA Detection
… biomarkers via liquid biopsies. Extracellular vesicles have shown promise as a noninvasive biomarker for disease diagnosis and monitoring, and have become a treasure trove of information because they have been found to carry proteins, DNA, mRNA and microRNA as well surface markers indicative of …
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Dysfunction of ciliary vesicle trafficking in ciliopathies
Contains fulltext : 181326.pdf (Publisher’s version ) (Open Access)
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Molecular analysis of vesicle biogenesis during autophagy
… is degraded in the vacuole. The release of PMN vesicles at the NV-junctions requires at least three membrane fusion events. Krick et al. reported that the standard homotypic vacuolar fusion machinery is not required for the formation of PMN vesicles. This study indicates the requirement of Cdc48 …
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Synaptic vesicle recycling <i>in Vivo</i>
Die Grundlagen der Reizweiterleitung an Synapsen sind prinzipiell gut verstanden: Wenn ein Aktionspotenzial die Synapse erreicht, induziert es einen Kalziumeinstrom, der wiederum zur Fusion synaptischer Vesikel mit der Plasmamembran führt, woraufhin die in den Vesikeln enthaltenen Neurotransmitter …
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Regulation of Synaptic Vesicle Trafficking at Central Synapses
… in the brain. At presynaptic terminals, synaptic vesicles fuse with plasma membrane in response to electrical stimulation, followed by rapid retrieval to the terminal and re-organization for reuse. Thus, synaptic vesicle trafficking is of interest as to where presynaptic regulations of synaptic …
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Vesicle-associated Membrane Proteins in Airway Mucin Secretion
… protein. One type of SNARE protein, a Vesicle-Associated Membrane Protein (VAMP), has been shown to regulate exocytosis in multiple cell types.</p> <p>Here, we report that VAMP8 has the highest gene expression among all VAMP isoforms in human airway secretory cells, as revealed by an …
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Cell behaviour during optic vesicle morphogenesis in medaka
… starts with the bilateral evagination of optic vesicles from the forebrain. A failure of evagination leads to the complete absence of eyes. Despite a good knowledge about patterning and retina differentiation, the mechanism underlying evagination remained largely unknown. Studies on optic …
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Munc18 function in large dense-core vesicle exocytosis
… studied the role of Munc18 in large dense-core vesicle exocytosis in adrenal chromaffin cells. We combined complementary techniques (electrophysiology, electronmicroscopy) to assay docking, priming and Ca2+ triggered fusion of the vesicles. First, we further confirmed the view that Munc18-1 is a …
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Dense Core Vesicle Heterogeneity in Anterior Pituitary Cells
<p>Peptides, which are packaged in dense core vesicles, are an integral part of the function of the endocrine and neurological systems. The dense core vesicles function as an efficient form of peptide storage prior to regulated exocytosis. Two different dense core specific transmembrane proteins …
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Neurons under tension: A study of vesicle dynamics
… and present my Ph.D. research on the dynamics of vesicles in neurons under tension. To understand the role of mechanics in neuron function, we must take a closer look at the underlying subcellular dynamics. The basic goal of this research is to explore the currently unknown relationship between …
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Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therapy
Extracellular vesicle (EV) release from tumour cells plays an important role in cancer drug resistance. It is essential that chemotherapeutic drugs are retained within target cells for increased efficacy in inducing apoptosis and as microvesiculation influences drug retention, this study has …
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Membrane Lipids and Synaptic Vesicle Trafficking in the CNS
Most vesicles within a synapse are dormant. The rest participate in synaptic neurotransmission, with a portion of these preferentially fusing first. Moreover, all synapses experience spontaneous neurotransmitter release which may originate from the random exocytosis of vesicles prepared to fuse …
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Molecular Determinants of Synaptic Vesicle Exocytosis and Endocytosis Coupling
Synaptic vesicle recycling is essential for maintaining normal synaptic function. The reuse of vesicles maintains the size of the presynaptic terminal and ensures the availability of synaptic vesicles for subsequent exocytosis. The coupling of exocytosis and endocytosis allows for continued rapid …
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