Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"vertical transmission"”.
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Viral and Host Factors Associated with HIV-1 Vertical Transmission and Pathogenesis
… and infants acquire HIV-1 infection through vertical transmission. In addition these HIV-1 infected infants have a higher viral load and progress to AIDS faster than adults, often times more rapidly than their own infected mothers. However, the mechanisms of this differential disease …
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Evaluating the Impact of Antibody Epitope and Function on HIV-1 Vertical Transmission
… the design of an effective HIV vaccine. Vertical transmission of HIV is a natural setting where the role of pre-existing antibodies on HIV acquisition can be directly studied. During gestation, infants receive maternal HIV-specific antibodies via placental antibody transfer and these …
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Placental co-culture model reveals Listeria monocytogenes utilization of monocytes for vertical transmission
… use of the “Trojan horse” method for vertical transmission. Human monocyte THP-1 cells were exposed to L. monocytogenes (MOI 100) for one hour to ensure infection. The co-culture model was exposed to varying treatments including the L. monocytogenes-infected THP-1s for two hours to …
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Vertical transmission in the culicoid vector as a possible mechanism for bluetongue virus transeasonality
… objective of this study was to determine if vertical transmission of BTV in the culicoid vector is the mechanism for BTV transeasonality in regions of temperate climate.
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The experience of being pregnant and HIV positive and undergoing treatment against vertical transmission of HIV
Bibliography: leaves 76-81.
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Exploring the Experiences of HIV Positive Pregnant Women on Prevention of Vertical Transmission of HIV/AIDS in Rural Malawi
<p>Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) continues to be the primary conduct that HIV is transmitted to children worldwide. The problem of HIV/acquired immunodeficiency syndrome (AIDS) is having a great impact on the world's children. The prevalence of HIV/AIDS …
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Unravelling the role of Bacteroides and Phocaeicola in the human gut: exploring evolutionary dynamics, mother-to-infant vertical transmission, and functional characteristics
… metabolites, genetic and evolutionary features, vertical transfer, persistence and relative abundance of Bacteroides and Phocaeicola in early life. Characterization of a new species of Bacteroides and a potential Phocaeicola probiotic strain were also carried out. In Chapter 1, the current …
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Syphilis in Pregnancy: Exploring the prevalence and vertical transmission prevention cascade of syphilis using routinely collected electronic health data, Cape Town Metropolitan District, 2017–2022
… is notifiable in South Africa. CS results from vertical transmission of inadequately treated syphilis in pregnancy, a treatable sexually transmitted infection caused by Treponema pallidum. Gaps in our understanding of syphilis epidemiology exist amidst concerns of penicillin stockouts increasing …
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The formulation and refinement of a polymerase chain reaction (PCR) assay for early diagnosis of paediatric HIV infection and genetic analysis of variants involved in vertical transmission of HIV-1
… infants are infected through mother-to-child transmission, with the frequency of vertical transmission varying between 12,9% and 65%. In order to implement appropriate management and possible treatment of these infected neonates, it is essential to have reliable laboratory tests for the early …
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Approaches towards vaccine development against Neospora caninum
… 1.5 x107 tachyzoites per mouse delivered i.p. Vertical transmission rates in C57BL/6 mice infected with N. caninum tachyzoites during mid-gestation were determined and found to be in the range of 96-100%. Putative protective antigens of N. caninum that included MIC1, MIC3, GRA2, GRA6 and SRS2 …
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Maintaining pathogens with short infectivity in seasonally structured tick populations: relative importance of three transmission pathways
… in tick populations. In addition to systemic and vertical transmission, cofeeding transmission has been proposed as an important route for the persistence of pathogens with short infectivity (e.g., tick-borne encephalitis causing viruses, TBEv). Because cofeeding transmission requires ticks to …
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Molecular Mechanisms of HIV-1 Infection: Viral and Host Determinants in Transmission and Pathogenesis
HIV-1 vertical transmission is the predominant cause of AIDS in children. In addition, HIV-1 infected infants have a higher viral load and progress to AIDS more rapidly than infected adults. However, the molecular mechanisms of HIV-1 vertical transmission and pathogenesis are not known. Work …
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The prognostic value of HIV viral load in predicting viraemic outcomes of post-partum women on antiretroviral therapy: a secondary analysis of two randomised controlled trials from Gugulethu, Cape Town
Background: Vertical transmission of HIV continues to be a significant health concern for HIV-infected women in pregnancy and postpartum, especially in Southern Africa, despite decreasing rates of infection. While better access to effective and acceptable antiretroviral therapy (ART) regimens has …
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Feasibility, validity and utility of HIV testing data as key components of HIV case-based surveillance
… to ascertain sentinel events within the HIV and vertical transmission prevention cascades. Temporal trends in HIV prevalence, HIV testing, linkage to care, ART coverage and vertical transmission estimates were evaluated and where relevant, triangulated with other key data sources historically …
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Mixing it up: Multiple symbiont acquisition strategies as an adaptive mechanism in the coral Stylophora pistillata
… from parent to offspring via direct inheritance (vertical transmission) or acquired anew each generation from the environment (horizontal transmission). Vertical transmission ensures progeny acquire their obligate symbionts, but progeny encountering an environment that differs from that of their …
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The influence of maternal HIV status on mortality in children under the age of five years
… five years get infected with HIV mainly through vertical transmission (Fishel, Ren, Barrère et al. 2014). In the absence of treatment, vertical transmission of HIV is high and can range between 15 and 45 per cent, reducing below 5 per cent with effective interventions (Barral, Oliveira, Lobato et …
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Microbial Communities of Spinach at Various Stages of Plant Growth From Seed to Maturity
… were grown in the field and growth chambers. Vertical transmission of bacterial community members was evident; the developmental stage of the plant affected the richness and abundance of select bacterial phyla. The bacterial richness of plants grown in the two environments was not affected. …
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Efetividade do pré-natal especializado para o controle da Infecção pelo HIV na gestação, no puerpério e na transmissão vertical, em um serviço de referência de Salvador – Bahia
Introduction: The transmission of HIV infection from mother to child during pregnancy, labor, birth and breastfeeding is still a severe public health problem in Brazil. The adherence to antiretroviral treatment (ART), during pregnancy and in the post partum period, is essential for strengthening …
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Congenital Chagas Murine Model Development and Nanovaccine Efficacy Against Maternal-fetal Trypanosoma cruzi Pathogenesis
… Trypanosoma cruzi (Tc) parasite can lead to the vertical transmission from mother to fetus known as congenital Chagas’ disease (cCD). The objective was to develop a murine model of cCD to test the efficacy of a DNA nanovaccine developed by our laboratory. In this dissertation, we demonstrate that …
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