Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"vertebrate embryo"”.
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DEVELOPMENT OF SINGLE-CELL MASS SPECTROMETRY TOOLS TO INVESTIGATE METABOLIC REORGANIZATION DURING EARLY EMBRYOGENESIS
… during tissue induction in the early developing vertebrate (frog) embryo. The work presented herein illustrates the strategies devised to advance single-cell analysis using capillary electrophoresis (CE)-MS. Additionally, this work features several contributions to our understanding of cell …
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Function of core promoters in differential gene regulation during embryogenesis
… differential gene regulation using the zebrafish embryo as an in vivo model system. To analyse the functional requirement for the general transcription factor TATA-box binding protein (TBP), a diverse set of promoters was tested for their TBP dependence. This analysis revealed a differential …
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Pumilio Regulates the Epithelial-Mesenchymal Transition and Gastrulation During Zebrafish Development
… to control developmental patterning events of invertebrates, germline stem cell maintenance, and neuronal growth through deadenylation, inhibition of translational elongation, and allow access of microRNAs to their targets. pumilio proteins have yet to be identified and functionally characterized …
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Endodermal Patterning in Xenopus laevis
The endoderm is the inner germ layer of the vertebrate embryo from which the respiratory and digestive systems are derived. These include organs such as the liver, pancreas, stomach, lungs and intestine. Recent research has helped our understanding of early vertebrate endoderm specification and …
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Regulation of morphogen signalling during neural patterning in the Xenopus embryo
… need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and …
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Molecular and biochemical characterisation of phosphorylation-dependent NICD1 turnover: novel roles for CDK1 and CDK2
In the developing vertebrate embryo, segmentation initiates very early and in a species-specific manner through the formation of somites, which later give rise to the vertebral column, most skeletal musculature and dermis. Somites are gradually and periodically pinched off from the anterior end of …
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The regulation of tissue proportions: analysis of progenitor behavioural dynamics in response to cell ablation in the zebrafish tailbud.
In order to form a correctly patterned embryo the behaviour of cell populations and tissues must be coordinated so that different structures form with the correct relative proportions. The fundamental body plan of the vertebrate embryo is laid down in a head to tail progression known as primary …
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The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord
Neural tube is a structure within the developing vertebrate embryo that gives rise to the central nervous system consisting of the brain and the spinal cord. Within the neural tube, there are pools of specific neural progenitors that give rise to specialised types of neurons. Those progenitors are …
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Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons
… never before been reported. It is certain that embryonic tissue will not be routinely used as a cell source for transplantation therapy in PD. Yet, stem cells bear a great potential for future PD therapy. Recent publications show that DNs of the midbrain subtype could be differentiated from stem …
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Cell Memory and Fate in Human Development
… development, particularly in organisms such as vertebrates, where embryonic cells become progressively restricted in their potential through a hierarchy of decision points guided by the signals they receive. All cells contain the same genetic information in the form of DNA, and we now know that …
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Elektroporation: Eine Methode zur Transfektion von Wirbeltierembryonen
… die Veränderung ihres Schicksals während der Embryogenese des Vertebratenembryos kann durch gezielte Überexpression morphoregulatorisch wirkender Proteine erreicht werden. Neben viralen Gentransfersystemen bieten sich aufgrund ihrer leichten Handhabung verschiedene auf physikalischen …