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Showing 1 to 20 of 49 for “"verapamil"”.
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Aktivierung des nukleären Transkriptionsfaktors kappaB (NF-kappaB) durch Verapamil
… und Endothelzellen wurden mit verschiedenen Verapamilkonzentrationen und unterschiedlich lange mit Verapamil inkubiert. Die Proteine der Zellen wurden gewonnen. Anschließend wurden Western Blots zur Identifizierung von Bestandteilen des Transkriptionsfaktors NF-kappa B und dessen …
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The interaction of verapamil with the human malaria parasite : Plasmodium falciparum
Includes bibliographical references (leaves [129]-144).
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Toxicological Analysis of Tacrines and Verapamil on the Yellow Fever Mosquito, Aedes aegypti
… at solubility limits; however, the addition of verapamil enhances toxicity of both tacrine and bis(7)-tacrine to mosquitoes. Verapamil significantly increases the mortality of mosquitoes exposed to tacrine and bis(7)-tacrine compared to the tacrine- and bis(7)- tacrine-only treatments. Tacrine …
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Stereoselective metabolism of verapamil and four other chiral drugs by cDNA expressed CYP450's.
Stereoselective metabolism of verapamil and four other chiral drugs by cDNA expressed CYP450's.
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Design, synthesis and biological evaluation of verapamil analogues, reversed isoniazids and hybrid efflux pump inhibitors against Mycobacterium tuberculosis
… modification of a known efflux pump inhibitor, verapamil (VER), and the development of hybrid efflux pump inhibitors (HEPIs) incorporating a VER motif; and (ii) the development of antimycobacterial agents based on covalent linking or attachment of efflux pump inhibitor moieties to an anti-TB …
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ΜΕΛΕΤΕΣ ΠΑΝΩ ΣΤΗ ΦΑΡΜΑΚΟΛΟΓΙΚΗ ΘΕΡΑΠΕΙΑ ΤΗΣ ΑΧΑΛΑΣΙΑΣ ΤΟΥ ΟΙΣΟΦΑΓΟΥ. Ο ΡΟΛΟΣ ΤΩΝ ΑΝΤΑΓΩΝΙΣΤΩΝ ΤΟΥ ΑΣΒΕΣΤΙΟΥ
… BLIND FASHION WITH DLA CEBO THE EFFECTS OF VERAPAMIL AND NIFEDIPINE ON THE RESTING PRESSURE OF THE LOWER ESOPHAGEAL SPHINCTER AND THEAMPLITUDE OF CONTRACTION OF THE ESOPHAGEAL BODY USING MANOMETRY IN PATIENTS WITH ESOPHAGEAL ACHALASIA, AND TO DETERMINE THE EFFECTS OF THESE DRUGS ON THE …
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Effects of organophosphate esters on blood vessels: a physiological, pharmacological, and histological assessment of involvement in organophosphorus-induced delayed neuropathy (OPIDN)
… but does not induce OPIDN. The capability of verapamil, a calcium channel blocker, to attenuate these responses was examined, as this agent ameliorates OPIDN. For the in situ study, the ischiadic artery was cannulated and alterations in pressure measured at a constant flow used to indicate …
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Studies on the role of the autonomic nervous system in airway hyperreactivity.
… Ca2+ - channel (VDC) blocking drugs, verapamil and nifedipine, attenuated responses to applied ACh and stimulation of the vagus nerve in untreated tissues, indicating significant VDC involvement in the production of spontaneous and evoked tone. The calmodulin antagonist, …
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The Effects of total and partial inhibition of the sodium and pottassium-activated Adenosine Triphosphatase on the isolated perfused rabbit heart
… action of 0.51 and 2.04 umol. I"’ verapamil in- hearts perfused with ouabain, and 2.04 umol. 1"’ verapamil in preparations exposed to 1.1 mmol. 1“'' correlated with the drug's ability to preserve ATP and CP. This protective action on cardiac energy metabolism was not mediated by an …
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ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΤΟΥ PAF ΣΤΟ ΚΥΚΛΟΦΟΡΙΚΟ ΣΥΣΤΗΜΑ ΤΩΝ ΕΠΙΜΥΩΝ ΚΑΙ ΣΤΗ ΡΥΘΜΙΣΗ ΤΗΣ ΜΕΤΑΦΟΡΑΣ ΙΟΝΤΩΝ ΣΤΟ ΠΡΩΤΟΖΩΟ TETRAHYMENA PYRIFORMIS
… EXPLANATION OF THE AGEPC ACTION TWO DRUGS (VERAPAMIL AND DIGOXIN) WERE USED AS POSSIBLE INHIBITORS AND WHICH ARE OFTEN USED IN CARDIAC DISEASES. IN THIS STUDY THE CELL OF THE PROTOZOO TETRAHYMENA PYRIFORMIS WAS USED. AFTER I.V. ADMINISTRATION OF AGEPC IN RATS, IT CAUSES HAEMOCONCENTRATION, …
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Effect of combinations of drugs on glioma chemotherapy
… study was also carried out using P-gp inhibitor, Verapamil Hydrochloride. The study revealed that the cytotoxic effect of Paclitaxel increased in the presence of Verapamil Hydrochloride. In conclusion, the hypothesis that combinations of chemotherapeutic drug are more effective than single agent …
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Efflux-Mediated Multidrug Tolerance in Replicating Mycobacteria
… the addition of the calcium channel blocker, verapamil reverses this tolerance to the front-line drugs, isoniazid and rifampicin. If the tolerance mechanism revealed by my work is indeed a substantial contributor to the tolerance of active tuberculosis, then the addition of efflux pump …
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Physiology and pharmacology of flatworm muscle
… sensitive to the phenylalkylamine VOCC blocker verapamil, which reduced their amplitude in concentration-dependent manner. The platyhelminth-derived FMRFamide-like peptide (FLP) YIRFamide significantly increased current amplitude at 1muM. YIRFamide's ability to amplify the inward currents was …
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Cardioprotective Effect of Lipid Emulsion on Acute Exogenous Drug Intoxications // Кардиопротективен ефект на липидна емулсия при остри екзогенни интоксикации с медикаменти
… incident clinical administration of LE in acute Verapamil poisoning in humans and to determine whether LEs have a cardioprotective effect in an experiment with rats. Our study would have significant scientific and applied value for both clinical practice and experimental medicine. This knowledge …
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Development of a model cell culture system in which to study early effects of neuropathy-inducting organophosphates
… OPIDN in hens. The modifiers (aldicarb and verapamil) were used as a 5 minute pre-treatment, simultaneous treatment, and a 2 minute post-treatment. Significant prevention of most of mipafox-induced NTE inhibition and aging was observed. Effects on NTE inhibition and aging in differentiated …
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T-type calcium channels and human mesangial cell proliferation
… This effect was not seen upon incubation with verapamil, an L-type calcium channel antagonist. DNA synthesis in MC treated with each of the T-CaCN antagonists was significantly reduced by up to 50% as shown by BrdU incorporation. This anti-proliferative effect was not associated with direct …
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Mechanisms of Ionophore Toxicoses: Laidlomycin Propionate Toxicosis in the Horse and Monensin, Laidlomycin, and Laidlomycin Propionate in Muscle Cultures
… was not influenced by addition of nifedipine, verapamil, or magnesium.
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Proteasome Inhibition As A Potential Anti-Breast Cancer Therapy: Mechanisms Of Action And Resistance-Reversing Strategies
… therapeutic strategies has been warranted. When verapamil, a L-type calcium channel blocker with P-glycoprotein (P-gp) and CYP3A4 inhibitory properties, is combined with MG132 or bortezomib or carfilzomib, the cytotoxic effects and apoptosis in TNBC MDA-MB-231 cells were enhanced, compared to …
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