Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"ventromedial hypothalamus"”.
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Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
… expressed in the ventrolateral region of the ventromedial hypothalamus (vlVMH), a sex-dimorphic structure that directly modulates brown adipose tissue (BAT) thermogenesis. We previously showed that an ERαvlVMH-originated neural circuit responds to changes in ambient temperature and nutritional …
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Role of the ventromedial hypothalamus in control of innate defensive behaviours
… of the circuit controlling these behaviours. Ventromedial hypothalamus (VMH) is a key brain region for controlling responses to predators; it has been shown that inactivating the VMH can reduce defensive behaviours. Interestingly, activating the VMH output neurons (SF1+ cells) can produce a …
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Role of Ceramide Accumulation in the Ventromedial Hypothalamus in Driving Systemic Metabolic Impairments During Obesity
… that during obesity ceramides accumulate in the hypothalamus, the region of the brain known to regulate many aspects of metabolism. As hypothalamic lipid metabolism is rapidly being established as a key player in whole-body metabolic homeostasis, we became interested in whether this ceramide …
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Possible role of the ventromedial hypothalamus in estrus termination following vaginocervical stimulation of the rat
… the present study investigated the role of the ventromedial hypothalamus (VMH) in estrus termination using sexually experienced ovariectomized female rats. First, females were administered subcutaneous injections of estradiol benzoate and progesterone before being assigned to 4 different …
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Effects of progesterone on newly synthesized proteins in the ventromedial hypothalamus of the estrogen-primed female rat
… dependent on exposure of the medial basal hypothalamus to estrogen and progesterone. These hormones are thought to exert their effects by acting on DNA to alter protein synthesis. Alternatively, due to its short latency to act, progesterone may work by affecting cyclic nucleotide activity.
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Does the Stria Terminalis Carry Information Concerning Feeding and Body Weight Regulation from the Posterodorsal Amygdala to the Hypothalamus?
… the brain, 2) coronal knife-cuts anterior to the ventromedial hypothalamus, and 3) axon-sparing lesions of the posterodorsal amygdala using ibotenic acid. Both lesions of the dorsal stria terminalis and coronal knife-cuts anterior to the ventromedial hypothalamus resulted in significant weight …
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CHARACTERIZATION OF TRANSMEMBRANE PROTEIN 35 EXPRESSION: CONSIDERATIONS OF SEX AND OVARIAN HORMONES
… identified high expression of TMEM35 in both the ventromedial hypothalamus (VMH) and the limbic circuit of the mouse brain. Due to the known functions of these two regions, this pattern of expression indicates possible roles of this neuropeptide in social behavior and reward processing. …
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The Effects of Progesterone on Extracellular Serotonin Levels in Rat Hypothalamus
… on extracellular serotonin were monitored in the ventromedial hypothalamus (VMN), midbrain central grey (MCG) and medical preoptic area (POA) using microdialysis. Rats primed with estradiol benzoate (5 μg) were anesthetized with choral hydrate (400 mg/kg, i.p.). Samples were collected at 20 minute …
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Opioid induction of Fos in the female rat brain : modulation by ovarian hormones
… in the lateral septum, medial preoptic area, ventromedial hypothalamus, medial amygdala, and mesencephalic central gray. The present study found that Fos immunoreactivity was induced differentially by the opioid agonists within the different brain regions, and the hormones either augmented or …
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Exploring INSL5 and RXFP4 in the gut-brain axis and their potential role in feeding behaviour
… cells in the colon, DRG, NG and the ventromedial hypothalamus (VMH), a known feeding centre in the brain. Transcriptomic analysis of Rxfp4-expressing cells in the hypothalamus revealed enriched expression of multiple feeding-related neuropeptides and receptors. Circuit mapping of …
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Food intake in birds: hypothalamic mechanisms
… regions including the lateral hypothalamus, paraventricular nucleus, ventromedial hypothalamus, dorsomedial nucleus, and arcuate nucleus and I measured gene expression of various appetite-associated factors in the whole hypothalamus and individual nuclei. These data provided …
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Hypoglycemia-induced changes in glucose metabolism in the hypothalamus
… understood (3), but changes occurring in the ventromedial hypothalamus (VMH), a brain region that is responsible for initiating the counterregulatory response to hypoglycemia (4) is the most promising target. In the following studies, we utilized metabolomic (Chapter 2), transcriptomic …
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Mechanisms of intake depression in parasitised lambs
… experiment involved blocking the activity of the ventromedial hypothalamus (VMH) using mederantil, a compound with the active ingredient brotizolam, which blocks the diazapem receptor in the VMH. The second eXI)eriment utilised loxiglumide (CR1505) which antagonises the peripheral receptor of …
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Hypothalamic Regulation of Food Intake in Obese and Anorexic Avian Models
… homeostatic regulation of appetite is the hypothalamus, and hence this dissertation was focused on understanding how the hypothalamus is different between LWS and HWS lines. Experiments 1 and 2 were performed as follows: whole hypothalamus as well as individual hypothalamic nuclei, …
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Neurological - Molecular Interface in Food Intake and Metabolism in Birds and Mammals
… regulation in the brain, particularly the hypothalamus, is the main factor governing food intake. Neuropeptide Y (NPY), known as a potent orexigenic factor, also promotes energy storage in fat in mammals and thus has a dual role in promoting energy intake via appetite regulation in the …
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Metabolic signalling and neuroendocrine stress responses in pregnancy
… in the lateral hypothalamic area (LPIA), ventromedial hypothalamus (VMH) and dorsomedial hypothalamus (DMH). Supraoptic and magnocellular PVN oxytocin responses to centrally administered NPY were reduced during late pregnancy. Endogenous opioids are involved in the attenuation of HPA axis …
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Mechanisms of hypothalamic regulation of food intake in birds
… central and peripheral neural signaling. The hypothalamus is responsible for integrating and processing these signals and thus is regarded as the regulatory center for balancing energy homeostasis. Eating disorders, such as compulsive eating behavior associated with obesity, and anorexia, are …
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The development and plasticity of visuo-spatial orienting behaviors and underlying circuitry in adolescent mice
Sex differences in visual processing during behavior exist across a wide variety of species, from flies to humans. However, it remains unclear whether sexual dimorphism in natural visual behavior exists for standard laboratory strains of mice, a prominent model for understanding the neural basis of …
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A neural and behavioural investigation of aberrant feeding in animal models of autism spectrum disorder
… in the central amygdala (CEA), dorsomedial hypothalamus (DMH), ventromedial hypothalamus (VMH) and the nucleus accumbens (Acb). Excessive consumption palatable sucrose sucrose was was ameliorated in mutants by intraperitoneal administration of oxytocin (OT), a satiety promoting neuropeptide …
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Effects of Ventromedial Hypothalamic Lesions on Food-Reinforced Fixed Ratio Responding
… shown that rats with experimental lesions in the ventromedial area of the hypothalamus become obese due to hyperphagia. This striking effect on ad libitum food intake is sometimes accompanied by an increase and sometimes by a decrease in other measures of propensity to eat such as food-rewarded …