Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"ventricular zone"”.
-
Retinal development and age related degeneration following gestational lead exposure
… post-mitotic rod and bipolar precursors in the ventricular zone of developing retina; and increased and accelerated the age-related degeneration of rod photoreceptors and bipolar cells. CONCLUSIONS: Gestational exposure to environmental toxicants such as lead can produce differential …
-
Confirmation of Emx2 Protein Binding Partners
… the progenitor layer of the neocortex, the ventricular zone. Despite the vast amount of progress that has been made in describing how these transcription factors impact the organization of the neocortex, much more work is still needed to elucidate the molecular mechanisms that involve these …
-
Dividing the Preplate: Characterization of Neuronal Subpopulations in the Early Murine Cerebral Cortex
… the preplate is split into an upper marginal zone and the lower subplate layer by the radial migration of projection neurons from the cortical ventricular zone. Cajal-Retzius and subplate neurons have important developmental functions in regulating radial migration and in pioneering …
-
A Map of Transcription Factor Expression in Neuronal Precursors of the Chicken and Mouse Embryonic Cerebellum
… radial glial fibers in their transit from the ventricular zone (VZ) to the differentiating mantle zone. As cerebellar histogenesis proceeds, granule cell progenitors (Meis1+/Math1+) form the external granule layer and cerebellar nuclei neurons (Irx3+/Meis1+/Meis2+) migrate circumferentially off …
-
Analysis of Novel Genes Whose mRNAs are Enriched in the HVC-Associated Telencephalon of Songbirds
… song control nuclei or the neurogenic ventricular zone), and whether the RNA's abundance changes at times when anatomical and functional changes are known to occur in these regions. Sequence analysis demonstrated that 4 of these clones encode novel proteins with suggestive or …
-
Radial Glia and the Migration of Young Neurons in the Adult Avian Brain
… functional circuits. These cells are born in the ventricular zone (VZ) of the lateral ventricle, sometimes up to 5-6 mm away from the location were some of these neurons finally mature (Nottebohm, 1985). How do new neurons find their way through the adult parenchyma away from the ventricle and …
-
Characterization of subtypes of precursor cells in the developing central nervous system
… we could show by morphologically tracing ventricular zone precursor cells, that cells with a radial morphology constitute the majority of precursor cells in the CNS during neurogenesis. Furthermore, we here present indications showing that radial glial cells divide without retracting their …
-
Removal of Pax6 from cortical progenitors renders them abnormally likely to switch fate in response to Sonic Hedgehog activity
… expressed by neural progenitors in the cortical ventricular zone (VZ) where it regulates neurogenesis and fate specification. The complex processes of neurodevelopment are also regulated by morphogens such as Sonic Hedgehog (Shh) that promotes ventralization of the ventral telencephalon (vTel), …
-
Spatial and temporal regulation of cerebral cortex development by the transcription factor pax6
… laminar positions and accumulate in the ventricular zone (VZ) of the postnatal mutant cortex. Collectively, these gain- and loss-of-function studies suggest that disruption of Pax6 levels during different developmental time points leads ultimately to impaired formation of superficial …
-
PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS
… cell (RGC) fate. Disruption of AJs can lead to ventricular zone disruption, loss of normal apicobasal polarity, and RGC detachment from the apical surface. Since proper cortical layering depends on RGC detachment from the AJ belt, differentiation and subsequent neuronal migration, we developed a …
-
Characterisation of a conserved motif found within the Dlx cis-regulatory element URE2 and its effect on mouse URE2-lacZ activity in transgenic mice
… were modified, was active in the cortex and the ventricular zone of forebrain of the transgenic mice produced with the mutant enhancer, where Dlx1/Dlx2 are not usually expressed. This indicated a loss of binding by a protein with a transcriptional repressor function. Previous analyses suggested …
-
Temporal and spatial controls of cell fate specification in the cerebellum
… rise to all the cells of the cerebellum: the ventricular zone and the cerebellar rhombic lip. The rhombic lip comprises a dorsal progenitor population, defined by the expression of the transcription factor Atoh1, which gives rise to different cell types contributing to both extra-cerebellar …
-
Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
… expressed in the progenitor population in the ventricular zone but not in mature neurons in the mantle zone. When isolating the Ngn2-expressing cells and their direct descendants by FACS from an Ngn2-GFP-KI mouse, I found that the Ngn2-GFP-positive cell fraction contained dopaminergic neurons, …
-
Serum Response Factor Regulates Multiple Aspects of Central Nervous System Development
… in the number of proliferative cells in the ventricular zone from embryonic day 14 to day 18, suggesting that SRF-deficient precursor cells accumulate as they fail to acquire post-mitotic glial cell-fates. In contrast, conditional SRF deletion in developing forebrain neurons: Srf-NEX-cKO) did …
-
Distinct Roles for Dynein Regulatory Proteins NudE and NudEL in Brain Development
… downward (apical) movement in the proliferative ventricular zone (VZ) of the brain. Research from our lab has identified dynein, along with LIS1, as being responsible for apical movement, and the unconventional kinesin Kif1a as the driving force behind basal movement. The aim of this thesis has …
-
Uncovering the role of notch signaling in development of hypothalamic nuclei in vivo and using in vitro microenvironments
… controlled in two nuclei: the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (ARC). Although the function of a large number of these functional cell types has been studied in great detail, the developmental cues associated with fate decisions of a common progenitor remain …
-
Effect of Rat Strain Stereotactic Coordinates on Infarct Volume
Ischemic stroke makes up 87% of all hospital-admitted stroke cases annually; the primary treatment for these cases is intravenous administration of tPA within a 3.5 hour window from stroke onset. A long-term delayed ischemic stroke treatment proposed by this study was a combination of the …