Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"ventricular arrhythmias"”.
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Computer simulation of a novel technique for Radio-Frequency Ablation of ventricular arrhythmias
Ventricular Tachycardia (VT) is a rapid arrhythmia, most commonly due to reentrant electrical activity in the heart. A common treatment for VT is Radio-Frequency Ablation (RFA), which is minimally invasive, but requires maintenance of VT until the target site for ablation is determined. Most …
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Electrophysiologic Characterization of the Arrhythmogenic Substrate in Reentrant Atrial and Ventricular Arrhythmias Insights from the Clinical and Experimental Electrophysiology Laboratories
… in patients with structural heart disease and ventricular arrhythmias. Such advancements in elucidating the mechanisms and pathophysiology underlying scar-related ventricular tachycardia have yielded improved clinical outcomes for patients with drug-refractory ventricular arrhythmias. Chapter 1 …
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Agreement between gadolinium-enhanced cardiac magnetic resonance and electro-anatomical maps in patients with non-ischemic dilated cardiomyopathy and ventricular arrhythmias
… procedural outcome after catheter ablation of ventricular arrhythmias (VA). We identified 50 patients with NIDCM who underwent CMR and ablation for VA. LGE was detected in 16 patients (32%), mostly in those presenting with sustained VT (15 patients). Low-voltage areas (<1.5 mV) were observed in …
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Synchronous rhythms in coronary heart disease: an hypothesis concerning the anomalous nature of some common ventricular arrhythmias - investigation with an electronic analogue
Various temporal aspects of arrhythmias containing frequent, single ventricular ectopic complexes are investi¬ gated using 24 hour tape recordings of ECGs, High-speed electronic analysis of records containing such complexes reveal characteristics difficult to reconcile with existing theories of the …
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Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias
Ventricular arrhythmias are difficult to study in man. The current experimental models are arrhythmias induced by electrical stimulation, coronary artery ligation or by subsequent reperfusion. An electrophysiological model will be useful for exploring the cellular mechanism of arrhythmias and for …
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Improving Patient Safety by Calculating the QT Correction in Critical Care Patients
… precursor to Torsades de Points and other lethal ventricular arrhythmias. 52% or patients in critical care units have prolonged QTc and 69% or critical care patients have risks of developing QTc. Many commonly administered medications in the critical care unit are known to prolong QTc yet a …
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New Paradigm of Defibrillation: Towards Painless Therapy
… year in the United States. It usually starts as ventricular tachycardia: VT) and then degenerates into ventricular fibrillation: VF). Implantable cardioverter defibrillator: ICD) therapy is the only reliable treatment of VT/VF and has been shown to effectively reduce mortality by many clinical …
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Mechanisms of ventricular arrhythmogenesis in the age dependent Pgc-1β -/- model of mitochondrial dysfunction.
… death is a leading cause of mortality worldwide. Ventricular arrhythmias, both ventricular tachycardia and ventricular fibrillation, are the primary arrhythmias that lead to sudden cardiac death. A large proportion of ventricular arrhythmias are ischaemic in origin. However, increasing clinical …
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Arrhythmia heart disease classification using deep learning
… 80% of sudden cardiac death is the result of ventricular arrhythmias. Arrhythmias may occur at any age but are more common among older people. Arrhythmias are caused by problems with the electrical conduction system of the heart. Therefore, we have designed a model using supervised deep …
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Electrocardiographic predictors of clinical outcome in ST-elevation myocardial infarction
Malignant ventricular arrhythmias, particularly ventricular fibrillation (VF), remain an important contributor to mortality in ST-elevation myocardial infarction (STEMI). The size of myocardial injury is one more important factor influencing the prognosis of STEMI patients. The search for new …
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The relationship between repolarisation alternans and the production of ventricular arrhythmia in heart failure
… alternans is thought to predict the risk of ventricular arrhythmias in patients with heart disease, although recent clinical studies have conflicting results. Understanding the cellular basis for alternans may not only inform more effective utilisation of the clinical test, but also provide …
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Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations
… opsin (GtACR1) to terminate atrial and ventricular arrhythmias in 3D patient-derived models. Additionally, a 2-state photocurrent model for GtACR1 is introduced. Chapter 4 studies the use of subthreshold optogenetic stimulation to up- and down-regulate early afterdepolarization …
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Cardiac PI3Kα Signaling and K+ Channel Regulation in Cardiac Hypertrophy and Heart Failure
… and increased risk of life-threatening ventricular arrhythmias. Previous studies demonstrated that repolarizing K<super>+</super> current densities are decreased in pressure overload-induced left ventricular hypertrophy, resulting in action potential and QT prolongation. Cardiac …
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The pharmacological modification of reperfusion injury with particular reference to calcium fluxes in the isolated rat heart
… in the genesis of reperfusion stunning and arrhythmias. The study was also aimed at elucidating the possible sources and entry pathways contributing to this proposed cytosolic Ca²⁺ overload. In order to investigate the possible role of altered reperfusion Ca²⁺ fluxes in reperfusion injury, …
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Multiple Electrode Recording of Cardiac Activation.
… signal analysis. This is inadequate for studying arrhythmias which can be transitory in duration. The improved electrode array consisting of 64 (or more) electrodes can be applied directly to the epicardial surface and can record the total epicardial activation sequence within a few beats. The …
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Sodium Channel Loss of Function Sensitizes Conduction to Changes in Extracellular Sodium Concentration
… death is largely attributable to sudden onset ventricular arrhythmias. Alterations in cardiac conduction, particularly the slowing of conduction velocity is one major factor in arrhythmogenesis. By understanding the mechanisms and factors that modulate cardiac conduction velocity, we can assess …
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Incidence and Clinical Predictors of Risk Factors for Inappropriate Shock in Patients with Implantable Cardioverter-Defibrillators
… in diagnosing and treating life threatening arrhythmias, inappropriate shock therapy (IST) occurs in approximately 5-20% of ICD recipients. IST results in pain, anxiety, induction of ventricular arrhythmias, decreased battery longevity, and even death. Researchers studying clinical predictors …
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Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
… associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these pathologies due to their sudden and transient etiologies has hindered successful translation of therapies to the clinic. Given the multi-billion-dollar economic burden that …
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Cardiovascular magnetic resonance and right ventricular angiography in assessment of right ventricular volumes, function and wall motion abnormalities in arrhythmogenic right ventricular cardiomyopathy: a comparative study
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterised by structural changes to mostly the right ventricle (RV) that predisposes to ventricular arrhythmias heart failure and sudden cardiac death. ARVC is diagnosed using the 2010 Task Force …
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