Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"ventral tegmental area"”.
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Examining cholinergic fuction in the ventral tegmental area and dorsal hippocampus
Midbrain dopamine (DA) neurons project from the ventral tegmental area (VTA) to the prefrontal cortex (PFC) and ventral striatum (NAc and OT) forming a key part of the well-defined mesocorticolimbic system, as well as the hippocampal-VTA loop. The mesocorticolimbic system, at least partly, mediates …
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DISRUPTED GABA SIGNALING IN THE VENTRAL TEGMENTAL AREA DRIVES ADDICTION-LIKE BEHAVIORS
… effects of many commonly abused drugs. The ventral tegmental area (VTA), a central hub of this circuitry, is well known for its robust dopaminergic projections to forebrain regions and their crucial roles in modulating reward, aversion, motivation and cognition. However, VTA GABA cells, …
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Nicotine Alters Gene Regulatory Networks in Dopaminergic Neurons in the Ventral Tegmental Area
… Dopaminergic (DA) neurons originating from the ventral tegmental area (VTA) of the brain are activated by nicotine and form the natural reward pathway that is known to contribute to addiction. In recent years, microRNAs (miRNAs) have been found to post-transcriptionally regulate gene expression …
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Role of the ventral tegmental area, cannabinoid receptors and GABA neurons in motor activity
… components of brain reward circuits, such as the ventral tegmental area (VTA), may offer important insights into modulation of behaviors associated with drug abuse. The VTA includes DA-containing and GABA-containing neurons which provide important forebrain control over the limbic system. The …
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Neuronal and Molecular Adaptations of GABA Neurons in the Ventral Tegmental Area to Chronic Alcohol
… and molecular adaptation of GABA neurons of the ventral tegmental area (VTA). GABA neurons are of interest with regards to ethanol intoxication, reinforcement, and dependence due to their widespread distribution and connectivity to mesocorticolimbic dopamine (DA) neurons implicated in alcohol …
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Ventral Tegmental Area Neuronal Responses to Methylphenidate Correlated to Behavioral Responses of Adolescent and Adult Rats
… effects of the drug on brain development. The ventral tegmental area (VTA) is a site of psychostimulant action thought to be involved in behavioral sensitization. The aim of the this study was to first determine if there are differences in neuronal responses between individuals, with respect to …
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Social isolation enhances calcium signaling and synaptic plasticity in dopamine neurons of the ventral tegmental area
… its effect on dopamine (DA) neurons of the ventral tegmental area (VTA) is unknown. The data presented in this dissertation demonstrate that social isolation of rats during a critical period in adolescence (postnatal days 21-42) enhances long-term potentiation (LTP) of N-methyl D-aspartate …
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Full-Gestational Exposure to Nicotine and Ethanol Results in Long-Term Dysregulation in the Ventral Tegmental Area
… acid (GABA) and glutamate modulators of ventral tegmental area (VTA) dopamine (DA) neurons that project to the nucleus accumbens (NAcc).</p> <p>Our animal model of full gestational exposure to Nic+EtOH exposes the developing brain to both drugs throughout the entire 3 trimester human …
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Serotonin 5-HT<sub/>2C</sub> receptors: Role in (+)-MDMA sensitization and distribution in the ventral tegmental area
… 5-HT<sub/>2C</sub>R protein expression in the ventral tegmental area (VTA), nucleus accumbens (NAc), or prefrontal cortex in either (+)-MDMA- or MK 212-pretreated rats. However, an up-regulation of 5-HT<sub/>2C</sub>R protein expression was observed in the VTA at 2 wks withdrawal in MK …
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Nucleus accumbens dopamine and investigatory behavior : modulation by the ventral subiculum of the hippocampus through the dopamine cell bodies of the ventral tegmental area
… both dopamine (DA) containing neurons of the ventral tegmental area (VTA) and glutamate containing neurons from the ventral subiculum (VS) of the hippocampus. VS projections to the NAS have been suggested to influence investigatory behavior, at least in part, by evoking glutamate-mediated …
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Electrical stimulation of reward sites in the ventral tegmental area of the rat increases dopamine transmission in the nucleus accumbens as measured by in vivo microdialysis
… of electrical brain-stimulation at sites in the ventral tegmental area (VTA) that supported intracranial self-stimulation (ICSS). In the first experiment, both ICSS and yoked-stimulation of the VTA evoked significant increases in extracellular concentrations of DA, its metabolites, and …
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Fos induction within the ventral tegmental area following infusions of phencyclidine, MK-801, and nomifensine into the core and shell subterritories of the nucleus accumbens septi
… GABAergic output neurons projecting to the ventral tegmental area (VTA). Independent groups of animals were tested to determine whether infusions of PCP, MK-801, or nomifensine directly into the core or shell subterritory of the NAS would induce Fos expression within the VTA. Each rat …
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Effects of blockade of muscarinic receptors in the ventral tegmental area : attenuation of cocaine reward, but enhancement of locomotor activity and dopamine overflow in the nucleus accumbens
… involvement of cholinergic projections to the ventral tegmental area in the rewarding effects of cocaine. Bilateral intracranial injections of the muscarinic receptor antagonist atropine into the ventral tegmental area attenuated the rewarding effects of intravenous cocaine self-administered on …
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The interactive and individual effects of orexin A and neurotensin in the brain on spontaneous physical activity.
… intake following injection of orexin A into this area. The acute effect is also observed with bicuculline-mediated stimulation of neurons in the rostrolateral hypothalamus. It is likely that there are other peptide signaling systems which are downstream of orexin receptor activation in the …
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Benzodiazepines and Dopamine Mediated Behavior
… effects of benzodiazepines on catalepsy and the ventral tegmental area.
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Maternal Behavior in the Rat: Neuroendocrine and Neuroanatomical Substrates
… pathway connecting the preoptic region and the ventral midbrain regulates the performance of maternal behavior by female rats. There Is also evidence that the facilitatory action of estrogen on maternal behavior is mediated via estrogen target cells In the medial preoptic region. Neither the …
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Variation in postpartum maternal care programs the development of neuroendocrine and mesolimbic dopamine pathways in female offspring
… maternal behavior such as the medial preoptic area of the hypothalamus. The first series of experiments within this thesis demonstrates that these neuroendocrine differences in ERalpha-immunoreactivity and mRNA emerge in offspring during the postnatal period (postnatal days 0-21). These studies …
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Haloperidol-Environment Interaction Modulates Expression of c-Fos Proteins in the Basal Ganglia in Rats
… neurons in the nucleus accumbens core and ventral pallidum was significantly lower in the Paired rats than in the Unpaired and Saline rats, even though all groups received haloperidol on the test day. Compared to the Saline group both the Paired and Unpaired groups showed evidence of lower …
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Activation of the corticolimbic brain by visual food cues; Effect of menstrual cycle phase and mood
… Activity was present in the hippocampus, ventral tegmental area and nucleus accumbens in response to high calorie images but not low calorie images during the follicular phase. The insula showed selective activity responding to high calorie pictures in the luteal phase and low calorie …
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