Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"ventral striatum"”.
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Νευροφαρμακολογία και λειτουργική ανατομία των βασικών γαγγλίων του εγκεφάλου: Πειραματική μελέτη σε επίμυες
… years however it has become apparent that the neostriatum is not an homogeneous structure. Thus in order to investigate regional differences within striatum concerning asymmetric locomotor behaviours, rats with unilateral, total, dorsal or ventral ibotenic acid induced striatal lesions were …
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Characterizing Reward Function During Social Feedback: Associations with Anhedonia in Socially Anxious Adolescents
… victimization) are associated with the degree of ventral striatum suppression and anhedonia symptoms in a social stress context. A total of 29 adolescents between the ages of 13 and 17 years old (Mage = 15.31; SD = 1.51; 55.2% cisgender girls) participated in the present study. Participants were …
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Hedonics, Reward Prediction, and Reinforcement Learning in Schizophrenia: Relationships to Anhedonia and Avolition
… activity in response to positive stimuli in ventral striatum and amygdala, regions associated with salience and reward. The second process we examined was reward prediction, which describes anticipatory responses to cues that predict reward. This process is thought to be mediated by the …
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Mechanisms Underlying the Adverse Consequences of Stress: A Role for the Dynorphin/Kappa Opioid Receptor System, p38α MAPK, and the Serotonin Transporter
… serotonin transporter (SERT) specifically in the ventral striatum in a GRK3 and p38α MAPK dependent manner, and hypothesize that this regulation leads to a hyposertonergic tone. Future work elucidating the downstream effects of hyposerotonergic tone in the ventral striatum is required, but the …
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Expectation, the placebo effect and Parkinson's disease : an investigation using high-resolution positron emission tomography
… improvement stimulates dopamine release in the striatum. In the work described in this dissertation, positron emission tomography with [¹¹C] raclopride was used to investigate the relationship between the strength of expectation of benefit and the degree of dopamine release in PD, and how this …
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Brain substrates of behavioural endophenotypes predictive of compulsive drug-seeking
… grey matter volume in the infralimbic cortex and ventral striatum. Functionally, compulsivity and stickiness were predicted by decreased connectivity between the prelimbic cortex and the anterior cingulate cortex with the posterior dorsomedial striatum. In summary, this thesis supports previous …
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Neural and Behavioral Evidence for a Link Between Mobile Technology Usage and Intertemporal Preference
… usage and white matter connectivity from the ventral striatum (vSTR) to the ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC), pathways that have been previously implicated as biological markers for individual differences in intertemporal preference. Regression …
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Predicting learning success from patterns of pre-training magnetic resonance images
… (BOLD) brain activity in the dorsal but not the ventral striatum, recorded before training, predicts subsequent learning success with high accuracy. The fact that the high prediction accuracy of the data did not depend on the task subjects were performing during the recording might suggest that …
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The Neurobiology of Reward Processing in Adolescence
… Monoamine Oxidase A (MAOA) is associated with ventral striatal brain activation during reward anticipation and 4) to investigate whether MAOA stratifies the relationship between ventral striatal activation and ADHD symptoms in boys. Objectives 1 and 2 were explored using the full IMAGEN dataset …
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Enhanced striatal glutamatergic function upon chronic antipsychotic action
… enhances glutamatergic function in the ventral striatum through translational alterations and increased synaptic function. Cell type-specific mRNA profiling on spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways following chronic antipsychotic …
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Separating Within-trial Activities in the Stop Signal Task Using fMRI
… innervated by midbrain dopamine neurons (dorsal striatum and ventral anterior cingulate cortex (ACC)), followed by deactivations during post-error adjustment in structures that modulate the ascending dopamine response (ventral striatum and caudal orbitofrontal cortex), which encode error …
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Probing the Mechanisms of Reinforcement Learning: Reinforcement Learning, Ventral Striatal Astrocytes, and the Dynamic Coordination of Information Seeking with Learning
… task, and attenuated the astrocyte activity in Ventral Striatum (VS), Dorsolateral Striatum (DLS), and Dorsomedial Striatum (DMS). We found that mice, whose astrocytes in VS were targeted, showed decreased bandit performance and increased win-stay behavior. Throughout computational modeling, we …
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Defining Genes and Circuits Affecting Naïve and Experience-Dependent Alcohol Preference in Drosophila melanogaster
… RSU1 are associated with brain activation in the ventral striatum during reward anticipation in adolescents and alcohol consumption in both adolescents and adults. Together, these data suggest a conserved role for integrin/Rsu1/Rac1/actin signaling in modulating reward-related phenotypes, …
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The role of frontal cortical-basal ganglia circuits in simple and sequential visuomotor learning
… to elucidate the role of frontal cortex and striatum in visuomotor learning. Several tasks were used to characterize motor function including: a visuomotor reaction time (VSRT) task, measuring response speed and accuracy to luminance cues; simple stimulus-response (S-R) learning, measuring …
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Examining cholinergic fuction in the ventral tegmental area and dorsal hippocampus
Midbrain dopamine (DA) neurons project from the ventral tegmental area (VTA) to the prefrontal cortex (PFC) and ventral striatum (NAc and OT) forming a key part of the well-defined mesocorticolimbic system, as well as the hippocampal-VTA loop. The mesocorticolimbic system, at least partly, mediates …
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The influence of anesthesia and nicotine on dopamine signaling in the rat dorsal striatum
<p>The striatum is highly innervated by dopamine neurons and is involved in movement control (dorsal striatum) reward learning (ventral striatum). Fast-scan cyclic voltammetry (FSCV) is a technique that uses microelectrodes (diameter ~5 μm, length ~150 μm) to monitor dopamine signaling in the …
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Cortical - Basal Ganglia Circuits: Control of Behaviour and Alcohol Misuse
… and limbic (ventromedial prefrontal cortex and ventral striatum (VS)) processes. In addition, cognitive and behavioural programs that pass through the cortical – basal ganglia circuitry can be subject to filtering by the subthalamic nucleus (STN), which receives direct projections from the …
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EXAMINING THE NEUROBIOLOGY OF NON-SUICIDAL SELF-INJURY IN CHILDREN AND ADOLESCENTS: THE ROLE OF REWARD RESPONSIVITY
… differences between regions of interest (ROIs; ventral and dorsal striatum [VS, DS], anterior cingulate cortex [ACC], orbitofrontal cortex [OFC], ventrolateral and ventromedial prefrontal cortex [vlPFC; vmPFC], and insula) and whole-brain connectivity (utilizing bilateral DS, mPFC, and insula …
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Functional organisation of behavioural inhibitory control mechanisms in cortico-basal ganglia circuitry: implications for stimulant use disorder.
… with the control group. In contrast, the ventral striatum was linked to incentive specific activation to reward anticipation. Task-based fMRI demonstrated that interactions between dorsal striatum and cingulo-opercular “cold cognition” networks underlie failures of impulse control in the …
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