Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"ventral midbrain"”.
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The role of the dopaminergic neurotrophin growth/differentiation factor-5 in the developing rat ventral midbrain
… been shown to be a trophic factor for embryonic midbrain dopaminergic neurons in vitro (Krieglstein et al. 1995) and after transplantation to adult rats in vivo (Sullivan et al. 1998). GDF-5 has also been shown to have neuroprotective and neurorestorative effects on adult dopaminergic neurons in …
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Engrailed genes are cell autonomously required for the survival of the mesencephalic dopaminergic neurons
… dopaminergic neurons of the substantia nigra and ventral tegmentum are the main source of dopamine in the central nervous system. The progressive loss of dopaminergic neurons in the substantia nigra compacta over several decades leads to one of the most prominent human neurodegenerative disorder, …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
… only compromise a very small percentage of the ventral midbrain, the Lund Human Mesencephalic cell line (LUHMES) was used in our study. LUHMES cells can be differentiated into mature dopaminergic neurons following a two-step differentiation procedure. The p75NTR was found to be activated and …
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The Role of Substance P in Opioid Induced Reward
… pathways to promote pain but also found in the ventral tegmental area associated with dopamine neurons. Studies have shown that Substance P can potentiate positive reinforcement of opiates and may play a role in opioid reward. Here using in vivo microdialysis, we show that systemic morphine …
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Maternal Behavior in the Rat: Neuroendocrine and Neuroanatomical Substrates
… pathway connecting the preoptic region and the ventral midbrain regulates the performance of maternal behavior by female rats. There Is also evidence that the facilitatory action of estrogen on maternal behavior is mediated via estrogen target cells In the medial preoptic region. Neither the …
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A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor
… be expressed in the dopaminergic neurons of the ventral midbrain and to function in the presynaptic modulation of dopamine release in the striatum. Results from dopamine release studies suggest that the abrogation of AGAP1-mediated recycling decreases the magnitude of presynaptic M5-mediated …
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mRNA EXPRESSION ANALYSIS OF MIDBRAIN DOPAMINE NEURONS IN RESPONSE TO NICOTINE INTAKE DURING MATURATION
… of dopamine (DA) neurons are located in the ventral midbrain comprising of the substantia nigra (SN) and the ventral tegmental area (VTA). Nicotine has been suggested as both neuroprotective and neurotoxic on the central nervous system (CNS). For many neurological disorders, nicotine has been …
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Effects of chemogenetic inhibition of dopamine transporter- or A2A-expressing neurons on spontaneous activity and motivation to consume a palatable food reward
… potentially dissociable roles of DA-releasing ventral midbrain and striatopallidal neurons on motivational processes, we employed double transgenic mice that expressed inhibitory DREADDs—designer receptors that are activated only by otherwise inert ligands—only in dopamine transporter (DAT) or …
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Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
… dopaminergic neuroblasts derived from fetal ventral mesencephalon (VM) are transplanted to the striatum, may be an alternative to pharmacological treatment of PD patients. The limited access and ethical concerns with using fetal tissue have prompted the use of stem cells as a renewable and …
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Tetrahydroisoquinoline Neurotoxins in Parkinson Disease
… dopamine synthesis and turnover such as the ventral midbrain and striatum, respectively. Significantly lower levels of (<em>R</em>)salsolinol, (<em>S</em>)salsolinol, <em>N</em>-methyl-(<em>R</em>)salsolinol and<em>N</em>-methyl-(<em>S</em>)salsolinol were found in the caudate nuclei of PD in …
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The role of Ubiquitin ligases Nedd4-1 and Nedd4-2 in the brain and their crosstalk with alpha-synuclein and other dementia-related proteins
… in the SN as Nedd4-2-deficient mice did. In the ventral midbrain the Mammalian Target of Rapamycin (mTOR) inhibitor RTP801 was found to be increased in Nedd4-1 and Nedd4-2 deficient mice, AKT phosphorylation only in Nedd4-1 deficient mice and the autophagy related p62 protein only in double …
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The role of the immune system in Parkinson’s Disease: from neuropathology to treatment.
… source of cells than previously used foetal ventral midbrain (fVM) tissue, which provided proof of principle for the replacement of DAn in PD but was associated with ethical and logistical issues. Work using the hESC-derived NPCs has now matured into early clinical trials (including STEM-PD, …
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Investigating the mechanisms by which PINK1 protects against Parkinson's disease
… and reductions in neurite length in cultured ventral midbrain neurons, in response to overexpression of wildtype or mutant α-synuclein, and to deletion of PINK1. Increased Golgi fragmentation and mitochondrial fission induced by the PD risk genes were significantly correlated with reductions …
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Specific connectivity and molecular diversity of mouse rubrospinal neurons
… the CNS. Descending pathways from the cortex and midbrain are involved in the control of voluntary motor output. This is made possible by their projections onto spinal interneurons and, to a degree that varies between species, directly onto motor neurons. However, the somatotopic organization and …
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Systems Genetics and Systems Biology Analysis of Paraquat Effects in BXD Recombinant Inbred Mice
… nuestros fenotipos de hierro en el cerebro medio ventral con fenotipos de conteos TH+ y determinar si existe una relación significativa entre ellos y validar o complementar nuestro grupo de genes ya determinados en este trabajo. Los resultados presentados aquí muestran el valor heurístico del …