Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"ventilator induced lung injury"”.
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Partielle Flüssigkeitsbeatmung im Vergleich zur konventionellen Beatmung und zur Hochfrequenzoszillation mit Surfactanttherapie : Auswirkungen auf Gasaustausch und Lungenpathologie im Neugeborenen-Tiermodell
… respiratory distress syndrome and to reduce ventilator associated lung injury. The aim of this study was to compare the effects of partial liquid ventilation combined with conventional ventilation (PLV/CV), CV combined with surfactant (S + CV) and High frequency oscillatory ventilation …
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A Patient-Specific Multiscale Model of Mechanical Ventilation of COVID-19-afflicted Lungs
… ventilation, which has a high risk of causing ventilator-induced lung injury. However, COVID-19 is a relatively recent disease, and there is a lack of detailed understanding of its response to mechanical ventilation. This thesis aims to create a multiscale physics-based computational modeling …
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Understanding mechanisms of, and risk factors for, lung injury in the critically ill
Ventilator-induced lung injury (VILI) can be associated with multiple organ dysfunction, yet the mechanisms underpinning it are unclear. It has been proposed that injurious mechanical ventilation can drive lung and distal organ injury through a process of biotrauma, and this was the focus of my …
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Effekte teilunterstützter Beatmungsmodi auf Hämodynamik, respiratorische Funktion und Gasaustausch beim experimentell induzierten akuten Lungenversagen im Schwein
… ventilation, which aimed to recruit injured lung tissue, revealed to be harmful to the lung itself (VILI, ventilator induced lung injury). The ARDS-Network study showed that an additional lung injury can be avoided by the use of low tidal volume via low peak pressure, which significantly …
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Tierexperimentelle Untersuchungen zu Praktikabilität und Hämokompatibilität einer miniaturisierten extrakorporalen Membranoxygenierung
… hypoxemia but causes further damage to the lungs. The ventilator-induced lung injury leads to irreversible lung damage and increases mortality. With extracorporeal membrane oxygenation using capillary membrane oxygenators specialized centers have the possibility to provide sufficient gas …
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Investigating the cerebral/pulmonary axis following traumatic brain injury in a preclinical model
Traumatic Brain Injury (TBI) accounts for 1,000,000 hospital admissions in the European Union every year and is the leading cause of death in individuals under 45 years of age in both Europe and the United States. This thesis examines the consequences to both the brain and lung following TBI using …
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VE-cadherin mechanotransduction signaling and its regulation by extracellular matrix
… (ECM) proteins and rigidity regulate the force-induced signaling pathway. In pathological situations like pulmonary fibrosis, the change of ECM can affect the endothelium permeability in response to mechanical perturbations. In this chapter, I showed that ECM proteins and the substrate rigidity …
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Conséquences hémodynamiques de l'application de la Ventilation Liquidienne Totale (VLT) dans un modèle expérimental de syndrome de détresse respiratoire aigue (SDRA) chez l'agneau nouveau-né
… être la cause d'une agression pulmonaire appelée Ventilator-Induced lung Injury (VILI), et aggraver le pronostic vital et fonctionnel des agressions pulmonaires aigue. La recherche de méthodes alternatives d'un support respiratoire pour les patients avec les SDRA les plus sévères qui permettraient …
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VENTILAZIONE MECCANICA E VOLUTRAUMA: STUDIO IN VIVO IN UN MODELLO SUINO
… is an essential support for patients with acute lung pathologies, such as acute respiratory distress syndrome and acute lung injury, and it is generally applied in chirurgical practice. Specialists are however aware that, despite of its “life saving” role, this practice presents several negative …
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Development of novel in vitro platforms to model the lung
… platforms to capture the complexity of the lung within in vitro devices. Specifically, we developed a breathing alveolus-on-a-platform that utilizes a microfluidic-pneumatic mechanism to subject the cells to heterogeneous strain arising from out-of-plane stretching akin to expansion and …