Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"venetoclax resistance"”.
-
Dissecting The Mechanisms of Venetoclax Resistance In Myelodysplastic Syndromes
… clinical response to BCL2 inhibition by venetoclax-based therapy. Our preliminary data reveal that MCL1 is one of the determinants of venetoclax resistance in MDS patients and that combining MCL1 inhibition and venetoclax can synergistically eradicate venetoclax-resistant MDS blasts and …
-
Modelling the effect of loss of function CREBBP mutations in the evolution and treatment of B cell acute lymphoblastic leukaemia (B-ALL)
… in B cells. A new potential use of Venetoclax in CREBBP mutated B-ALL cell lines or in combination with CREBBP inhibitors (Inobrodib) was discovered widening the use of Venetoclax to B-ALL. The hypothesised mechanism relies on the intrinsic ferroptosis sensitivity of CREBBP mutated …
-
Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
… of chronic lymphocytic leukemia (CLL), drug resistance remains a major challenge. CLL resistant to venetoclax (VEN) have limited available therapeutic options, especially when the leukemic cells have dysfunctional p53 and have relapsed on Bruton’s tyrosine kinase inhibitors (BTKi). The broad …