Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"vasculogenesis"”.
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Heparan sulfate glycosaminoglycan regulation of vasculogenesis
… Furthermore, recent studies have shown that vasculogenesis contributes to adult neovascularization in multiple settings. Harnessing the vasculogenic potential of embryonic stem cells is an emerging concept to generate neovasculature. The differentiation of embryonic stem cells into …
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Alternatively spliced isoforms of Fibronectin, Tenascin-R and other potential players in early vasculogenesis
The absence of both the EIIIA and EIIIB domains of fibronectin (FN) has been shown to negatively affect blood vessel formation and maintenance. Vascular defects have been observed in the yolk sacs of EIIIA/B double-null embryos by as early as embryonic day E9.5, and these defects are likely due to …
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Vasculogenic Scaffolds: How Cell-Cell and Cell-Matrix Interactions Regulate Vascular Differentiation and Morphogenesis
… cells seeded onto the VM exhibited more rapid vasculogenesis than cells seeded on the CCC regardless of cell type. Future work will look into developing a scaffold using collagen and other biomolecules that mimics the structure of the VM to determine its role in promoting vasculogenesis.</p>
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Delta Like Ligand 4 Is A Critical Regulator of Bone Marrow Cell Differentiation Into Pericytes/Vascular Smooth Muscle Cells and Is Essential For The Vasculogenesis That Supports The Growth of Ewing’S Sarcoma
We have previously shown that vasculogenesis, the process by which bone marrow-derived cells are recruited to the tumor and organized to form a blood vessel network de novo, is essential for the growth of Ewing’s sarcoma. We further demonstrated that these bone marrow cells differentiate into …
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Stromal Derived Growth Factor Alpha (Sdf-1Α) Induces The Differentiation of Bone Marrow Progenitor Cells (Bmcs) Into Pericytes By Regulating Platelet Derived Growth Factor B (Pdgf-B) Transcription
… This process of neo-vascularization, known as vasculogenesis, is essential for Ewing’s sarcoma growth with the soluble vascular endothelial growth factor, VEGF<sub>165</sub>, being the chemotactic factor for BMC migration to the tumor site. Inhibiting VEGF<sub>165</sub> in TC71 tumors …
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Characterizing the Phosphorylation State of Tie2 using SH2 Domain Fusion Proteins
… through two distinct processes in embryogenesis: vasculogenesis, whereby the primary plexus in the heart is formed along with embryonic and extraembryonic vasculature, and angiogenesis, which begins after vasculogenesis and results in the refinement and maturation of the branched vessel system. In …
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Mesothelial and Mural Cell Contribution to Vascular Development through PDGF Signaling
… embryogenesis and adulthood occurs through vasculogenesis and angiogenesis. Vasculogenesis is the de novo formation of blood vessels from mesoderm precursor cells. Angiogenesis is the formation of new vessels from existing vessels. Both processes involve hematopoietic, endothelial, and mural …
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Evaluation of Biomimetic and Alloy-based Materials for Orthopedic Applications
… On the other hand, given the crucial role of vasculogenesis in cell nutrition in the scaffolds, ECM mimics found to support osteogenesis were further evaluated for endothelial cell adhesion and migration. For the hydrogel systems presented in this manuscript, poly(ethylene glycol) diacrylate …
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The Role of Snail Homolog 1 in Embryonic Stem Cell Differentiation
… has also been demonstrated to be important in vasculogenesis. Snail-deficient mice display early vascular defects while Snail overexpressing tumors are associated with increased angiogenesis. We utilized our ES cell model as a means to better understand Snail's relationship with vasculogenesis. …
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Blood Vessel Development
… Chapter 3 focuses on the function of Rasip1 in vasculogenesis, angiogenesis and vessel maintenance in developing embryo and in adults. An observation of transient Rasip1 localization at apical membranes in endothelial cells during in vitro tube formation provided an insight where Rasip1 possibly …
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A 3D synthetic extracellular matrix that can be dissolved to interrogate the cellular local microenvironment on demand
… and cell-mediated matrix deposition. We use vasculogenesis of human iPSC-derived endothelial cells as a case study. Understanding vasculogenesis is a crucial requirement for engineering tissue models exceeding 100 gm due to nutrient diffusion limitations. Here we define microenvironment …
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THE ROLE OF SDF-1[alpha] AS A VASCULOGENIC CHEMOKINE AND ENDOTHELIUM-ASSOCIATED CELL ADHESION MOLECULE FOR THE RECRUITMENT OF BONE MARROW-DERIVED PROGENITOR CELLS TO DEVELOPING TUMORS
… SDF-1 alpha is an important mediator of tumor vasculogenesis, recruiting bone marrow-derived endothelial progenitor cells to tumors. We evaluated the role of SDF-1 alpha in the adhesion of bone marrow-derived lineage-negative cells to the murine Lewis lung adenocarcinoma (LLCaB subclone), both …
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Experimental estimate of the diffusivity of Vascular Endothelial Growth Factor
… crucial processes such as angiogenesis and vasculogenesis. This study aimed at obtaining an estimate of the diffusivity of VEGF by using a simple system consisting of an insert with a collagen membrane placed within the well of a cell culture plate. A solution of VEGF was added to the …
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In vitro study of cancer cell extravasation in microfluidic platform
… generated in the microfluidic system through vasculogenesis with addition of mural cells and pro-angiogenic factors to better replicate the normal physiological vasculature of the remote site for metastasis. Lastly, the vasculogenesis approach was combined with the bone-mimicking model to …
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Engineered, perfusable, human microvascular networks on a microfluidic chip
… the physiologic processes of angiogenesis and vasculogenesis to further elucidate their underlying mechanisms. In addition to using our platform for real-time observation of physiological processes, we also took advantage of the ability to influence these processes through precise control of …
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Peripheral arterial disease and diabetes: effects on endothelial progenitor cell differentiation and nitric oxide metabolism
… and properties. They can promote postnatal vasculogenesis by homing to, differentiating into an endothelial phenotype, proliferating and incorporating into new vessels. Consequently, EPCs are critical to endothelium maintenance and repair and their dysfunction contributes to vascular …
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The effect of the interstitial flow on the directional cell migration and sprouting of capillaries
… system, angiogenesis during wound healing, vasculogenesis during fetal development and lymphoangiogenesis are a few examples that depend heavily on interstitial flow. Pathologically, interstitial flow is observed when the vessels are abnormally leaky, such as the case in tumor-induced …
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
… brain endothelial cells and stromal cells during vasculogenesis. To integrate these features into a physiologically relevant blood-brain barrier model, we designed an in vitro microvascular network platform formed via vasculogenesis, using endothelial cells derived from human induced pluripotent …
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Endothelial injury and repair in vasculitis of the young
… growth factors involved in angiogenesis/vasculogenesis and endothelial progenitor cells. Circulating endothelial cells are mature endothelial cells which have become detached from the vessel wall and represent a highly damaged vasculature and were found to be significantly higher in …
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Integrated Disposable Microfluidic Tissue Chips
… of the system is validated in studies promoting vasculogenesis in a co-culture of endothelial and stromal cells.
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