Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"vascularized."”.
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Fabrication of Vascularized Renal Constructs
… move forward these renal constructs must be pre-vascularized. The basis for this work is the development of a novel, biomimetic pre-vascularization strategy. We have demonstrated the creation of collagen vascular scaffolds molded off of polycaprolactone vascular corrosion casts of normal renal …
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Microfluidic Platform for Vascularized Tissue Models
… a microfluidic platform designed to support 3D vascularized tissue models for microphysiological systems. The platform delivers pneumatic pressure and vacuum signals to drive fluid flow and pressure on tissue culture devices with integrated pumps and back-pressure regulators. The mechanical …
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Biomimetic and vascularized 3-d liver cancer model
… In order to achieve a biomimetic and vascularized in vitro model that would better recapitulate the cancer environment, a vascularized 3D in vitro liver cancer model is proposed in which: 1) heterospheroids, agglomerations of liver cancer HepG2 and stromal cells, are fabricated and …
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Thermal regulation of vascularized fiber-reinforced polymer matrix composites
… the tensile properties and damage evolution of vascularized PMCs are compared to non-vascularized PMCs. Results show that reductions in performance are associated with misalignment of the fiber architecture. Vascular architectures that only remove matrix without altering the structural fibers …
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Mechanical characterization and self-healing in synthetic vascularized materials
Inspired by natural healing processes, a variety of synthetic self-healing materials have been developed that mechanically recover from structural damage autonomously. One strategy for creating self-healing materials is to distribute reactive fluids throughout the material volume using a …
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A 3-dimensional vascularized cardiac tri-culture model using chitosan nanofiber scaffolds
… objective of this project was to develop a 3-D vascularized cardiac tissue model in vitro for improved survival and function. The cellular mosaic of the myocardial tissue demands the intricate integration of an extracellular matrix-like scaffold, cellular constituents, and biological factors. …
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A Bottom-Up Assembly Of Vascularized Bioartificial Constructs Using Ecm Based Microscale Modules
… of a simple yet efficient method for fabricating vascularized tissue constructs by fusing biodegradable microcapsules with tunable interior environments. Parenchymal cells of various types, (i.e. trophoblasts, vascular smooth muscle cells, hepatocytes) were suspended in glycosaminoglycan (GAG) …
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Building blocks for regenerative medicine : vascularized models and immunomodulation to engineer hepatic cell therapies
Despite significant advances in our knowledge about liver pathology and regeneration, non-palliative regimens for most end-stage liver disorders are limited. The only definitive treatment for end-stage liver failure is an orthotopic liver transplant. Unlike other major causes of mortality, death …
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Development of a Vascularized Carotid Artery Plaque Phantom for the Investigation of Novel Ultrasound-Based Technologies
… project was undertaken to develop a model of vascularized atherosclerotic plaque compatible with CEUS, and to apply it in the validation of a novel IPN quantification tool that calculates a normalized IPN enhancement ratio (NER). A variety of plaque mimics (n=92) were created to simulate …
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IN-VITRO VASCULARIZED TISSUE EQUIVALENTS FROM HUMAN EMBRYONIC STEM CELL-DERIVED ENDOTHELIAL AND VASCULAR SMOOTH MUSCLE CELLS
… hESC-derived vascular cells to engineer in-vitro vascularized tissue equivalents (VTE). Under feeder-free and chemically-defined conditions, we demonstrate efficient differentiation of hESCs into vascular progenitor populations using sequential modulation of Wnt, FGF, BMP and VEGF signaling …
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THE EFFECTS OF BONE GRAFTING ON CALVARIAL HEALING IN A RAT MODEL
… this study is to 1) develop a model to study non-vascularized and vascularized calvarial grafts; and 2) compare effects o f bone graft vascularity on calvarial healing. Thirty-six rats were divided into Control and Experimental (EXP) groups. Parietal defects were left empty on one side. …
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Distribution and metabolism of antibodies and macromolecules in tumor tissue
… drug resistance. The low overall uptake in vascularized tumors constrains the therapeutic index and lowers signal to noise ratios for imaging applications. Since antibody therapies are currently used to treat both bulk tumors and residual disease, an understanding of the limitations in …
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Tear Film VEGF in Dogs with Vascularizing Corneal Disease
… in tears from dogs with normal and<br />vascularized corneas. The first study used polyester rods for tear collection in dogs. Fluid volume and VEGF recovery characteristics, as well as potential binding of VEGF to the rod, were determined. Tears were harvested from normal dogs using rods …
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Η αξία του ημιτενοντώδους στις παραμελημένες ρήξεις του πρόσθιου χιαστού συνδέσμου: Αρθροσκοπικός και ιστολογικός έλεγχος
… In 2 cases, there was difinite development of vascularized neoplastic connective tissue on the surface of the graft. New vessels were noted. This neoplastic tissue was covered by one layer of synovial cells. We concluded that the semitendinosus tendon can offer stabilization and the base for …
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Biodegradable polymer scaffold fabrication and the creation of tissue-engineered bone
… able to form a clinically significant mass of vascularized bone with substantial compressive strength which was comparable to normal bone. Appropriately designed PLGA foams implanted against the periosteum allowed vascularized tissue ingrowth. We believe this tissue may have a large number of …
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Developing a biomaterial model of the glioblastoma perivascular niche to investigate the effects of angiocrine signals on disease progression
… We establish design principles for developing vascularized tumor models in gelatin hydrogels and workflows for evaluating heterotypic cell-cell interactions. Furthermore, we demonstrate the ability to establish and utilized vascularized biomaterial platforms to investigate the role of …
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ENGINEERING STEM CELLS AND ORGANOIDS ON A CHIP FOR THE STUDY OF HUMAN HEALTH AND DISEASE
… and perfusable microvascular beds and vascularized 3D human microtissues and ii) blood-retina barrier of the human retina. Using our vascular engineering strategy, we further demonstrate advanced capabilities of our microengineered models to incorporate patient-derived induced …
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Transplantation of the Mammalian Pineal Gland: Studies of Survival, Revascularization, Reinnervation and Recovery of Function
… material).</p> <p>Pineal grafts were well vascularized by fenestrated capillaries surrounded by consistently wide perivascular spaces. Moreover, nerve fibers and terminals were seen in the grafts within the anterior chamber of the eye, the third cerebral ventricle, and the pineal region (in …
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Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia
In transplantation, vascularized organs often suffer the consequences of ischemic damage as well as reperfusion injury following the reestablishment of blood flow. The induced ischemialreperfusion (I/R) damage is usually associated with the accumulation of injurious complement components. The …
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