Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"vascular tone"”.
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Regulation of peripheral vascular tone in spinal cord-injured individuals.
Contains fulltext : 70982.pdf (Publisher’s version ) (Open Access)
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Role of Protein Kinase G in Regulating Vascular Tone in Hypoxic Ovine Cerebral Arteries
… phosphorylate its target proteins that mediate vascular relaxation and contraction. A prominent target of PKG involved with vasorelaxation is the BK channel alpha protein. To examine the influence of LTH on PKG-induced vasorelaxation, and to demonstrate the relative influence of the BK channel …
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Expression and Function of Ca2+-Activated K+ Channels in Uterine Arteries
… of the most common insults to the maternal cardiovascular system and fetal development, and is associated with increased uterine vascular tone and heightened risk of preeclampsia and fetal intrauterine growth restriction (IUGR). The present study tested the hypothesis that calcium-activated …
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The impact of fish oil fatty-acids on post-prandial vascular reactivity.
Progressive loss of vascular reactivity and increased vascular tone with age are being increasingly recognised as significant cardiovascular disease (CVD) risk factors. The vasculature has emerged as a target for dietary strategies to modify these progressions. Our previous data suggest that …
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Endothelin system in human cardiovascular physiology and pathophysiology
… vessels in health, and the influence of cardiovascular disease on the ET system. This work followed from the discovery of ET-1 as a peptide endothelial mediator of vascular tone in 1988. Publications are grouped into sections representing different aspects of the work.
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Gitelman & Gordon: Mirror image syndromes reveal the roles of WNKs in blood pressure homeostasis and novel anti-hypertensive targets
… these mice were also discovered to have reduced vascular tone, it suggests the WNK pathway may have extra-renal roles in vascular smooth muscle function and highlights inhibition of SPAK function as a promising anti-hypertensive strategy with multiple sites of action. To address these …
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Signal Transduction Mechanisms Mediating the Regulation of Vascular G Protein-Coupled Receptors
… of GRK2 expression leads to alterations in vascular reactivity, vascular tone, and vascular smooth muscle cell (VSMC) signaling. Genetic knockdown of GRK2 expression results in a mouse that shows indications of intrauterine growth retardation phenotype and becomes spontaneously hypertensive …
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Upregulation of COX-2 protein expression in porcine macula densa with L-NAME treatment
… which is very important in modulating vascular tone and renal blood flow. Nitric oxide is produced from enzyme called nitric oxide synthase. Macula densa is a specialized structure in the kidney which co-localizes these two enzymes and is very important in maintaining the renal blood …
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The mechanism(s) of post-transcriptional regulation of the human constitutive endothelial nitric oxide synthase gene by tumor necrosis factor-alpha
… NO, plays a crucial role in the maintenance of vascular tone and homeostasis. Being a gas, NO can diffuse out of the endothelial cells into the underlying smooth muscle cells to cause vasodilation and into the lumen to prevent the blood platelets and leukocytes from clumping and adhering to the …
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Methyl esterification of fatty acids and eicosanoids with a novel reagent trimethylsilyldiazomethane for analysis by gas chromatography-mass spectrometry
… roles in inflammation and in the regulation of vascular tone. The prostaglandins are naturally occurring 20-carbon cyclopentano fatty acid derivatives produced in mammalian tissue from polyunsaturated fatty acids (PUFAs) and are generated from endoperoxide precursors of arachidonic acid and …
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Resistance training for patients with chronic heart failure
… gauge venous occlusion plethysmography. Vagal tone was assessed using heart rate variability. No medical complications arose during training or testing sessions. There were increases in upper body strength (42 ± 8; P = 0.037) and increases in lower body strength (22 ± 9%, P = 0.044) and …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
Vascular smooth muscle cells (VSMCs) are phenotypically plastic. Thus, while the VSMCs in healthy blood vessels are ‘contractile’ and control vascular tone, these cells can increase their synthetic, migratory and proliferative capacities in response to vessel injury. While largely adaptive, actions …
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Mathematical Models of Major Arterial Occlusion
… major arterial occlusion in multiple tissues and vascular geometries. A network representing the vasculature of the rat hindlimb is used to study peripheral arterial disease characterized by femoral artery occlusion. This work couples responses that occur on different time scales, namely vessel …
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Isolation, identification and characterization of vasoactive substances from endothelial cells, platelets and mononuclear leukocytes
… (Up4A) in plasma is sufficient to affect the vascular tone. The second part of the thesis deals with the isolation and characterisation of hypertensive agents in chronic renal failure (CRF) patients. In the secretome of mononuclear leukocytes, both Angiotensin II (Ang II) and …
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Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
… peptide (CGRP) and norepinephrine (NE) on vascular tone in the BIAA using functional measurements of contraction. 5-HT potently contracted BIAA rings with an BC50 = 0,81 ± 0.28 pM and was used to pre-contract rings sub-maximally for relaxation experiments. Concentrations of ACH of less than …
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Regional differences in the control of the cutaneous circulation in humans
… in nine healthy volunteers. Baseline cutaneous vascular conductance (CVC) (laser-Doppler flow / blood pressure) was measured at a local skin temperature (Tloc) of 33 °C and 42 °C. All data are expressed as CVC. In study 1, forearm and calf sites were compared to determine if SkBF differed by …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… is a key regulator of local blood distribution, vascular resistance and overall blood pressure (BP). Arterioles and capillaries are two important components of the microcirculation, which can undergo remodeling such as arteriogenesis, angiogenesis, or capillary rarefaction. Vascular remodeling …
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Altered Hemodynamic Control in the Skeletal Muscle Microcirculation in the Metabolic Syndrome: The Emergence of a new Attractor
Peripheral vascular disease is a pathological disease state whereby the peripheral vascular system becomes progressively limited in its ability to adequately perfuse extremities despite increases in metabolic demand. One of the primary risk factors for development of peripheral disease is the …
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Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… Atherosclerosis is a major cause of cardiovascular diseases, driven by vascular inflammation that begins with endothelial dysfunction. The endothelium, which lines blood vessels, plays a critical role in regulating vascular tone and immune cell interactions. In response to inflammatory …
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