Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"vascular response"”.
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Organ Specific Vascular Response to Fibrosis Affects Breast Cancer Metastatic Organotropism
… factor Angiopoietin 2 that increased vascular permeability of the lungs, but not the kidneys. In fact, while fibrotic lungs showed decreased expression of endothelial tight gap junction protein Claudin-5, the fibrotic kidneys had an elevated expression of Claudin-5.</p> <p>Our findings …
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THE VASCULAR RESPONSE WITHIN THE ISLET DURING BETA CELL DEVELOPMENT AND REGENERATION
… this mechanism and the potential role of the vascular system, neonatal rats were injected with streptozotocin to exacerbate this normal loss of β cells. Immunohistochemical and quantitative RNA analysis was performed to observe the ontogeny of changes to microvasculature, endocrine tissue, and …
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Role of angiotensin in the vascular response to chronic renal tubular obstruction
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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In Vivo Metabolic and Vascular Response to Hypoxia in Twist Knockdown Murine Breast Cancer
… should promote a shift away from glycolysis in response to reperfusion. </p> <p>To study the effects of Twist on metabolism in vivo tumors were grown in the dorsal skinfold window chamber and stressed by exposure to hypoxia. Knowledge of metabolism without information on the oxygen availability …
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The Role of Age and Model Severity on Cortical Vascular Response Following Traumatic Brain Injury
… of the mechanism(s) underlying cerebral vascular regulation will aid in establishing more effective treatment strategies aimed at improving cerebral blood flow restoration and preventing further neuronal loss. Our studies reveal an age-at- injury dependence on the Angiopoetin-Tie2 axis, …
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Isolation and purification of a vascular hyperreactivity factor from rabbit kidney cortex
Altered vascular response to agonist has been a consistently observed phenomenon in experimental animal and human hypertension. Much evidence suggests that a circulating factor of renal origin is, in part, responsible for this vascular hyperreactivity. The focus of this study was to isolate, purify …
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Mineralocorticoid receptor involvement in vascular dysfunction associated with vascular injury
… signaling has recently been implicated in cardiovascular dysfunction associated vascular injury. Specifically, MR blockade has been shown to treat coronary microvascular dysfunction in obesity and has been implicated in the regulation of capillary density in ischemic conditions. The fundamental …
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Cardiovascular Characterization of Cx40/Panx1 Single and Double Knockout Mice
… role in certain physiological processes such as vascular response.
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Intrinsic Optical Imaging of Cortex During Deep Brain Stimulation: Parameters, Spatiotemporal Dynamics and Neurovascular Coupling
… its spatial spread (two measures of hemodynamic response) increased linearly with increases in current amplitude or pulse width and had a non-linear relationship with frequency. Using simultaneous imaging and electrophysiology, I studied the relationship between DBS-induced neural and vascular …
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Cardiovascular and respiratory reflex control systems in the regulation of pulmonary blood flow and ventilation during exercise
… numerous factors, yet the role of certain cardiovascular and pulmonary reflex control systems is unknown. Therefore this thesis investigated the pulmonary vascular response to the activation of the muscle metaboreflex alone, and combined with activation of the muscle mechanoreflex. The …
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Computational model of local intravascular drug delivery
… and extrinsic to the device impact local intravascular drug delivery. Computational models of local fluid mechanics and drug transport were formulated to study how arterial drug uptake is modulated by local blood flow, stent placement, administered drug dose and release kinetics, and the …
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Postsynaptic Cholinergic Control Of Cardiac Function In Aging
… inotropic and coronary vasoconstriction responses of the aging heart to postsynaptic cholinergic stimulation.;The approaches used and the results demonstrated were the following. (i) Acetylcholinesterase activity measured by the method of Ellman et al (1961) declined significantly in the …
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THE RELATIONSHIP BETWEEN AEROBIC TRAINING AND CARDIOVASCULAR RESPONSE TO EXERCISE
… to be an important determinant of cardiac and vascular adaptations to aerobic training. In order to examine the relationship between hypervolemia and cardiovascular adaptations to aerobic exercise a series of cross-sectional and longitudinal studies were performed. Study 1 examined …
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Mathematical Models of Major Arterial Occlusion
… major arterial occlusion in multiple tissues and vascular geometries. A network representing the vasculature of the rat hindlimb is used to study peripheral arterial disease characterized by femoral artery occlusion. This work couples responses that occur on different time scales, namely vessel …
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Determination of physiologic states during mechanical circulatory support through characterization of device-organ interactions
… over the cardiac cycle during changing cardiovascular states. Parametric analysis revealed a hysteretic state-responsive relationship between the device and subject physiology. Since device operation is characterized using the MCL, unaccounted hysteresis changes can be attributed to variation …
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Pharmacokinetics of local growth factor delivery in myocardial tissue
… within heart tissue the compounds elicit a vascular response that is hoped to perfuse ischemic myocardium. There is, however, little quantitative data on macromolecular transport in myocardium, their fate after being delivered, how their transport is affected by structural properties of …
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Effects of oestrogen on haemodynamic and vascular reactivity - A study in animal models and humans
Effects of Oestrogen on Haemodynamic and Vascular Reactivity A study in animal models and humans Lisa Brandin Institute of Medicine, Department of Emergency and Cardiovascular Medicine, Sahlgrenska University Hospital/Östra, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden ABSTRACT …
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Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha
Vascular complications of diabetes account for the majority of morbidity and mortality among diabetic patients. Large clinical trials have identified hyperglycemia as a risk factor in the development of diabetic vascular complications. The effects of hyperglycemia on the vessel wall are not fully …
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Multi-modal molecular imaging of radiation therapy response in the tumour vascular microenvironment
… have shown that PAI could be used to assess response to radiation therapy and chemo-radiation therapy based on changes in the tumour vascular architecture and blood oxygen saturation, which are closely linked to tumour hypoxia. Given the strong relationship between hypoxia and …
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Renale Effekte von Angiotensin I und seinen Metaboliten bei experimenteller Hypertonie
Gegenstand der vorliegenden Arbeit war es, die Effekte von allen als aktiv angesehenen Metaboliten des Renin – Angiotensin – Systems sowohl auf den renalen Gefäßwiderstand, als auch auf die stimulationsinduzierte Freisetzung des Neurotransmitters Noradrenalin am Modell der isoliert perfundierten …