Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"vascular reactivity"”.
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Vascular Reactivity in Newly-Formed and Mature Arterialized Collateral Capillaries
… disease (PAOD) is a globally-prevalent cardiovascular disease in which atherosclerotic plaques narrow arterial lumen diameters and restrict blood flow to downstream tissues. The impact of these occlusions can be mitigated by collateral vessels that connect parallel arterial branches and act as …
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The impact of fish oil fatty-acids on post-prandial vascular reactivity.
Progressive loss of vascular reactivity and increased vascular tone with age are being increasingly recognised as significant cardiovascular disease (CVD) risk factors. The vasculature has emerged as a target for dietary strategies to modify these progressions. Our previous data suggest that …
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A study of vascular reactivity in women with pre-eclampsia using laser doppler fluximetry
… in-vivo technique, was used to assess cutaneous vascular reactivity in normotensive and pre-eclamptic women throughout pregnancy. The veno-arteriolar reflex was used as an index of peripheral vascular activity as it controls systemic resistance and thus blood pressure. Data collected …
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Vascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change
… implicated as a surrogate marker for impaired vascular reactivity in CAA. There have been no studies investigating how the BOLD amplitude changes in other Aβ diseases that present with CAA (Alzheimer’s disease (AD) or mild cognitive impairment (MCI)), or how it changes over time in CAA. BOLD …
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Sex differences in mesenteric endothelial function of streptozotocin-induced diabetic rats: The role of endothelium-derived relaxing factors
… suggest that diabetes affects male and female vascular beds differently. However, the mechanisms underlying the interaction of sex and diabetes remain to be investigated. This study investigates whether there are 1) sex differences in the development of abnormal vascular responses and 2) …
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LA VARIANTE ASSOCIATA ALLA LONGEVITA' (LAV) DEL GENE BPIFB4 MODULA eNOS E LA FUNZIONALITA' VASCOLARE
… BPIFB4, LAV-BPIFB4, to induce an improvement in vascular reactivity in opposition to changes in age. Thus, LAV-BPIFB4 may provide a potential tool for innovative therapeutic strategies aimed at fighting age-related dysfunction.
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Aspects of the interrelation between hypertension and insulin resistance: A preliminary study
… are again risk factors for other cardiovascular diseases such as atherosclerosis and heart fai lure. The nature of the association between hypertension and insulin resistance has not heen clearly elucidated. Spontaneously hypertensive rats are the ideal models to study the aspects of the …
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Sympathetic nervous system in the development of mild DOCA-salt hypertension
… sympathetic activity specifically to splanchnic vascular bed is required for full development of hypertension. I concluded that sympathetically mediated vasoconstrictor effects to the splanchnic organs are likely enhanced in mineralocorticoid hypertension due to increased responsiveness of the …
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Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis
… mediate or modulate one or more renocardiovascular effects of this peptide and have been implicated in hypertension. Since AA release is the rate limiting step in eicosanoid production, it is possible that cPLA2α might play a central role in the development of Ang II-induced hypertension. …
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Prenatal exposure to maternal obesity and SFLT-1 overexpression and cardiovascular function in the adult offspring
Cardiovascular disease is the leading cause of death in the United States. Adult smoking, type II diabetes, and other environments and conditions, have been identified as risk factors for cardiovascular diseases; however, the effects of prenatal development cannot be overlooked. In the 1980s Barker …
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Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
Cardiovascular disease remains the leading cause of mortality in the developed world. Over the past decades, investigations have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates cardiovascular disease including myocardial infarction. The impact of …
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The Impacts of Arterial Occlusion, Sex, and Exercise on Arteriogenesis and Functional Vasodilation
… and dilated diameters were increased, while vascular reactivity was minimal. By day 28, resting diameter decreased while maximal diameter was unchanged, causing an increase in functional vasodilation. Exercise training also improved vasodilation by decreasing collateral resting diameter. …
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A murine model of developmental programming of atherosclerosis
… activity and blood pressure measurements and vascular reactivity experiments in 4-month old animals did not demonstrate significant differences among study groups. No marked variation in serum cholesterol levels among genetically similar dams was detected.\r\n
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The role of fibroblast growth factor-2 (FGF2) in vascular remodeling and adaptation
… (FGF2) is required during diseased-related vascular growth and remodeling in the adult organism. Given previous research, it is generally assumed that FGF2 is an important regulator of vessel growth during various pathophysiological processes (e.g. tissue ischemia, vessel injury, and …
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Signal Transduction Mechanisms Mediating the Regulation of Vascular G Protein-Coupled Receptors
… and signaling molecules regulating blood vessel reactivity, members of the G protein-coupled receptor (GPCR) family are known to play a central role. GPCR activity represents a delicate, but coordinated balance between molecular mechanisms governing receptor signaling, desensitization, and …
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Mathematical Modelling of Brain Haemodynamics and Pressure-Volume Compensation
… on the performance of indices describing vascular dynamics were also examined. The background of this project is discussed in Chapters 1 to 4 of this thesis. Chapter 1 provides a description of the anatomical and physiological aspects of the cerebrospinal space, including the circulation …
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Characterisation of cardiac cellular and vascular function in Ischemic heart disease
… mostchronic cases of IHD are focused on the revascularisation of the ischemic region and the subsequentrestoration of blood flow. As such, the most prevalent therapeutic option is the coronary artery bypassgraft (CABG). In these procedures, the internal mammary artery (IMA) is deemed to be the …
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Anti-asthmatic and anti-cough activities of the essential oil Of Eucalyptus Grandis W. Hill Ex Maiden
… contraction studies where carried out using the vascular reactivity on aortic smooth muscle, and cytotoxicity assay done using the MTT assay on human embryonic kidney cells (HEK293) and human hepatocellular carcinoma cells (HepG2). The percentage yield of the essential oils from the fresh and dry …
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Maternal Obesity During Pregnancy: Cardiovascular Outcomes for Mother and Baby
… one risk factor for the development of cardiovascular disease (CVD), and CVD is the leading cause of death across the globe. Therefore, maternal obesity during pregnancy is associated with poor cardiometabolic health both during pregnancy and in later life. Children of obese women are at an …