Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"vascular physiology"”.
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Regulatory mechanisms of epithelial sodium channel
… we employed various techniques including electrophysiology and molecular biology approaches to investigate the mechanisms underlying the regulation of ENaCs by lipid metabolites, oxygen and mechanical stress. We have identified profound regulation mechanisms of ENaC in distal renal epithelial …
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Interaction between RSNO and H2S: The formation, stability, and NO-donating capacity of SSNO- and the effect of SSNO- on platelet activation
… mediator that has its own beneficial effects on vascular physiology. It has been implicated in the modulation of cellular processes including vessel tone/constriction, blood pressure, and tissue reperfusion. When S-nitrosothiols (RSNOs) react with excess H2S, they form several intermediates …
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Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle
… wall stress or sympathetic activity stimulate vascular wall angiotensin signaling, resulting in smooth muscle contraction which directly increases peripheral resistance. Calcium influx through voltage-gated L-type calcium channels underlies vascular smooth muscle contraction. Roughly half of …
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The BOLD MRI response of the brain to alterations in arterial blood pressure
… models. The first model represented cerebral vascular physiology (Ursino) and this fed into a second model (Buxton), which predicted the resulting BOLD signal changes. This allowed comparison with experimental BOLD data. TMD data was also compared to intracranial pressure changes predicted by …
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Regulation of the myogenic response and stretch-induced calcium signaling in the vascular wall: Novel insights into the role of microRNAs and protein tyrosine kinase 2
Intraluminal pressure has a significant impact on vascular adaptability, phenotype and regulation of blood flow and pressure. On one hand, increased pressure/stretch for a prolonged time can cause structural changes in vessel wall; on the other hand, lack of pressure/stretch can promote a phenotype …
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Histone Deacetylase 7 and Transcriptional Regulatory Networks of the Vascular Endothelium
… on HDAC7, a class II HDAC that is expressed in vascular endothelial cells and whose function is essential for the maintenance of vascular integrity during embryogenesis. Mice lacking HDAC7 die by e11.5 with complex cardiovascular malformations including endothelial, vascular smooth muscle, and …
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A novel in vivo tumor oxygen profiling assay: Combining functional and molecular imaging with multivariate mathematical modeling
… to obtain hemodynamic images. Finally, the vascular physiology measurements obtained from an anti-angiogenic therapeutic study in pancreatic tumors was applied to MPO2 and compared to therapeutic response. ^ Results: The simulation results using Green's function pO2 as standard showed that …
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Peripheral and Cerebrovascular Function during the Female Lifespan
… female hormone oestrogen is thought to influence vascular physiology throughout the female lifespan particularly during life events such as menopause and pregnancy. The rapid decline in oestrogen during the menopause is associated with increased cardiovascular (CV) risk, potentially via reduced …
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Functional neuroimaging studies of peripheral inflammation-related depression
… immune signals within the brain, and CNS vascular physiology, that can together better delineate mechanisms of interaction between the brain and the body as demonstrated here in inflammation-related depression.