Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"vascular permeability"”.
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Identifying Tumor Vascular Permeability Heterogeneity Using Reduced Encoding Techniques
"In our model, female Sprague Dawley rats with N-ethyl-N-nitrosourea (ENU) induced mammary tumors imaged with fast T1-weighted gradient echo DCE MRI following a Gd-DTPA injection, there is a window of resolutions that detects similar PS ""hot spots"" compared to those obtained from the clinical …
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Measurement of retinal vascular permeability in a rat model using spectroscopic optical coherence tomography
… is investigated to detect and quantify retinal vascular permeability changes in a small animal model. By injecting an intravascular dye that can act as a wavelength-dependent absorbing contrast agent into the bloodstream of a small animal, retinal vascular permeability changes induced by retinal …
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Vascular Permeability of the MDA-MD-231BR and RG-2 Brain Tumor Using Quantitative Fluorescence Microscopy
Embargo status: Restricted to TTU community only. To view, login with your eRaider (top right). Others may request the author grant access exception by clicking on the PDF link to the left.
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Improved Techniques For Acquisition and Analysis of Dynamic Contrast-Enhanced Magnetic Resonance Imaging For Detecting Vascular Permeability In The Central Nervous System
… quantitative assessment of regions with very low vascular permeability. In conclusion, applications of the improved DCE-MRI acquisition and analysis methods developed in this thesis work can improve the accuracy of the DCE-MRI results.</p>
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… MC activation in vitro to modulate vascular permeability, rosacea, cutaneous anaphylaxis, and itch in vivo. Utilizing peritoneal MCs (PMCs) that express MrgprB2, we showed that the absence of GRK2 resulted in enhanced β-hexosaminidase release in response to compound 48/80 (C48/80) …
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Studies on the immunopathologic mechanisms of intestinal lesion formation in turkey poults infected with hemorrhagic enteritis virus
… villus, there was also a concurrent increase in vascular permeability within the lamina propria which was demonstrated using colloidal carbon and vascular permeability within the lamina propria which was demonstrated using colloidal carbon and ferritin as vascular markers. The results of these …
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Notch deficiency leads to arteriovenous malformations and altered pericyte function
… membrane with the endothelium to provide vascular support. Pericytes are a critical component of the blood-brain barrier and regulate endothelial cell proliferation, vessel diameter, and vascular permeability. Endothelial cells express Notch1, whereas pericytes express both Notch1 and …
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Unraveling the Dynamics of Ser126 Phosphorylation in Paxillin: A Focus on Phosphatase Activity
… a key role in processes like angiogenesis and vascular permeability. This study aimed to identify the phosphatase responsible for dephosphorylating Ser126, a previously unexplored mechanism. Using recombinant paxillin and in vitro kinase assays, we confirmed that PKC phosphorylates Ser126. …
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Estudo comparativo do efeito de warifteína e metil-warifteína, alcaloides de Cissamplelos sympodialis ECHL (Menispermaceae), no processo inflamatório agudo.
… of paw edema induced by phlogistic agents in vascular leakage and cell migration in models of acute inflammation . Swiss mice (n = 4 - 6 ) were treated with phosphate buffered saline - PBS , 10mg/kg indomethacin , warifteíne or methyl warifteíne at doses of 2mg/kg and 10 mg / kg and were …
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Functional and Molecular Imaging Using Nanoparticle Contrast Agents for Dual-Energy Computed Tomography
… with dual energy CT in order to measure tumor vascular functional parameters, including tumor fractional blood volume and vascular permeability. These dual energy CT measurements were confirmed with ex vivo tissue analysis to demonstrate the validity and accuracy of the in vivo dual energy CT …
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Investigations into endothelial cell permeability and adherens junction disruption induced by Junín virus infection.
… hemorrhagic fever (AHF) characterized by vascular dysfunction and fluid distribution abnormalities. Clinical, as well as experimental studies, have implicated involvement of the endothelium in pathogenesis of AHF, although the role it may play is poorly understood. Junín virus has been …
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ROLE OF HYDROCORTISONE 21-HEMISUCCINATE DURING CARRAGEENAN-INDUCED ACUTE INFLAMMATION
… in the inflammatory site without affecting the vascular permeability. Levels of exudate leucocytes, volume, histamine and PGE2 were not significantly different from the control when hydrocortisone 21-hemisuccinate was injected directly into the air pouch, suggesting that the anti-inflammatory …
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Imaging biological water permeability barriers using CARS microscopy
Alterations in the water permeability of the vasculature are attributed to several disease processes including atherosclerosis, reperfusion injury, diabetes mellitus, aging, chronic inflammation, and cancer. While vascular permeability has been extensively studied throughout the years, many of …
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Cell penetrating peptide for ocular drug delivery
… population of the developed world. Choroidal neovascularisation (CNV), the hallmark of neovascular AMD, results in the loss of sharp central vision due to breakdown of the blood retinal barrier (BRB), unregulated blood vessel proliferation and vascular leak, particularly into the macula of the …
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Losartan, an angiotensin II receptor blocker, fails to attenuate pulmonary dysfunction in ovine burn and smoke model
… lung water content, and increased pulmonary transvascular fluid flux, and vascular permeability index. Although there was a trend for the reduction of lung lymph flow and permeability index, none of these alterations could be shown to be statistically affected by this dosage of losartan in this …
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Dynamics of vascular normalization during anti-angiogenic therapy : implications for combination therapy
… show that DC101, a monoclonal antibody targeting Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), prunes immature blood vessels, reduces vascular diameter and improves pericyte and basement membrane coverages. Functionally, the vascular permeability to macromolecules and interstitial fluid …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… by the blood-brain barrier (BBB), a selective vascular interface restricting passage of most molecules from blood into brain. Specific transport systems have evolved allowing circulating polar molecules to cross the BBB and gain access to the brain parenchyma. However, to date, few ligands …
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Premature vascular senescence during diabetic retinopathy
… dysfunction, which is characterised by increased vascular permeability, deficit in blood perfusion, vessel loss and increased inflammation. Cellular senescence has been implicated in the pathogenesis of diabetes; however, a role for cellular senescence in diabetic retinopathy is unclear. …
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G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
… responses including vasodilatiation, increased vascular permeability, and pain. GPER1 (G protein-coupled estrogen receptor 1) has recently been suggested as a novel estrogen receptor. Much controversy surrounds this receptor regarding its subcellular localization and activation. The aim of the …
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The multiple migratory mechanisms of systemically infused mesenchymal stem cells to sites of inflammation
… interactions with endogenous immune cells and vascular permeability. Finally, we conclude by proposing an integrated model of mesenchymal trafficking versus hematopoietic trafficking, and highlight the potential role of the intravascular compartment as a major site of MSC immunomodulation. We …
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