Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"vascular pathology"”.
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Characterization of The Vascular Pathology In The Acta2 R258C Mouse Model and Cerebrovascular Characterization of The Acta2 Null Mouse
… α-actin, predispose patients to a wide range of vascular diseases and is most commonly associated with thoracic aortic aneurysms (TAAD) and dissections (TAAD) and strokes. TAAD in patients is characterized by aortic media degeneration and loss in contractile force generation followed by aortic …
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Prospective Follow-up of Patients with Beta-Thalassemia Major for Cardio-vascular Status and Cardio-vascular Pathology /// Проспективно проследяване на сърдечно-съдовия статус и сърдечно-съдовата патология при пациенти с таласемия майор
Цел: Да се съпоставят ехокардиографски показатели при пациенти с Таласемия майор(ТМ) и здрави контроли; да се корелират тези показатели с биомаркер за сърдечна недостатъчност- NT-proBNP, за да се обхванат рано тези пациенти, при които има данни за сърдечна недостатъчност и да се оптимизира …
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Isolation, characterization, and functional assessment of novel smooth muscle like stem progenitors
Vascular smooth muscle cells (VSMC) are one of the key players in the pathogenesis of cardiovascular diseases. The origin of neointimal VSMC has thus become a prime focus of research. VSMC originate from multiple progenitors cell types. In embryo the well-defined sources of VSMC include; neural …
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Vascular biology in the menstrual cycle, pregnancy and pre-eclampsia
… cell (EPC) number are established indicators of vascular pathology and prognosis.
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Observations on cerebral amyloid angiopathy and microvascular pathology in Alzheimer's disease and vascular dementia
… dementing disorders are Alzheimer's disease and vascular dementia. Although Alzheimer's disease is very common and was described almost a century ago, the pathomechanisms are imperfectly understood, and mainly symptomatic therapy is available. Treatment options are even more meagre in vascular …
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Identification of biological markers for neuropsychiatric disorders
… with the hypothesis of a common substrate of vascular pathology in both dementia and depression in late-life.
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Investigating the role of TREM2 and neuroinflammation in an experimental model of chronic cerebral hypoperfusion
… cerebral hypoperfusion resulting from cerebrovascular disease is associated with the development of white matter damage, cognitive impairment and dementia. Although incompletely understood, recent studies suggest neuroinflammation is a key mechanism driving vascular pathology, white matter …
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Biomarkers of neurological tissue injury and inflammation in paediatric tuberculous meningitis
… high frequency of asymptomatic disease. Cerebral vascular pathology was documented frequently on imaging but did not predict infarcts. Low brain oxygenation was common and in keeping with physiological events and outcome. [ Conclusion ] CSF neuro- and inflammatory markers are elevated in TBM. …
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Notch signaling pathway in human vascular smooth muscle cell differentiation
… inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to mechanical stimuli. VSMC differentiation is a crucial developmental process regulating angiogenesis and vasculogenesis, with phenotypic modulation of SMC a key factor in vascular pathology. It …
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Cerebrovascular dysfunction : associations with midlife risk factors
… of dementia, a myriad of modifiable cardiovascular risk factors exacerbates and accelerate such risk. Identifying the individual and combined effect earlier in life is crucial to reduce their impact and to introduce positive changes in health behaviors. This dissertation focused on …
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The role of platelets in the pathogenesis of and immunity to helminth infections
… often the first to respond to tissue damage and vascular inflammation caused by pathogens. Here they not only maintain tissue integrity and prevent bleeding, but also initiate and regulate a vast variety of immunologic responses. Little is known on the role of platelets in helminth infections, …
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Endothelial progenitor cells, uraemic toxins, and the development of endothelial dysfunction in chronic kidney disease.
Morbidity and mortality rates for cardiovascular disease (CVD) are increased among end stage kidney disease (ESKD) patients receiving dialysis treatment, and not corrected with kidney transplantation (KTx). Classic CVD risk factors do not fully predict the increased risk, with novel factors causing …
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Gender differences in risk of neuropathology, cognitive decline and dementia in the Cognitive Function and Ageing Study (CFAS)
… group differences in the accumulation of cardiovascular risk factors and protective ‘cognitive reserve’ across the life course. The Cognitive Function and Ageing Study (CFAS) is a multi-centre population-representative study of ageing and dementia. This longitudinal study collected data on …
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Cerebral Amyloid Angiopathy-Causing Beta-Amyloid Variants Have Altered Effects on the Clotting System
… blood vessels, is a major contributor of vascular dysfunction in Alzheimer's disease (AD) patients. However, the molecular mechanism underlying CAA formation and CAA-induced cerebrovascular pathologies, including intracerebral hemorrhage (ICH) is unclear. Hereditary cerebral amyloid …