Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"vascular models"”.
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An Investigation into the Vascular Phenotypes of Breast Patient- Derived Xenografts
… Photoacoustic imaging (PAI) can visualise vascular features in the tumour microenvironment at multiple scales, building a complete picture of the vascular phenotype in a single tumour, which can be monitored longitudinally over time and noninvasively in vivo. It’s high spatiotemporal …
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Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery
… distributed within healthy and atherosclerotic vascular models. In the first part of the thesis we investigated the effect of drug physicochemical properties on drug deposition, retention, and distribution in a healthy vascular model. We found that hydrophobic drugs are deposited to a far …
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A multimodal approach to investigate the effects of respiration on Fontan flow to inform strategies for circulatory support
… Fontan IVC but bench top simulators and animal models fail to recreate the interaction of breathing and venous flow adequately. The goal of this dissertation is to develop and validate a suit of bench top and computational models which recapitulate the interaction of respiratory biomechanics and …
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Recapitulating Dynamic Disease States from In Vitro to In Vivo: The Pathophysiology of Cell Fusion in Breast Cancer Metastasis and New Model Systems of Intracranial Aneurysm
… therapies are studied using a variety of models. The specific models, or particular set of experiments, determine what questions can be answered about the disease model system. Here we look at three different model systems for studying both cell fusion in breast cancer metastasis and …