Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"vascular injury"”.
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Mineralocorticoid receptor involvement in vascular dysfunction associated with vascular injury
… signaling has recently been implicated in cardiovascular dysfunction associated vascular injury. Specifically, MR blockade has been shown to treat coronary microvascular dysfunction in obesity and has been implicated in the regulation of capillary density in ischemic conditions. The fundamental …
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A translational approach to understanding cellular responses to vascular injury
… is essential for maintaining open arteries after vascular injury. Connexin 43 is a channel protein that facilitates cell to cell communication and regulates cell proliferation as well as migration, yet it's role in vascular cell types is poorly understood. Here, I hypothesized that Cx43 and its …
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Vascular Injury In Col3A1+/- Mice Model of Vascular Ehler-Danlos Syndrome
<p>Vascular type of Ehlers-Danlos Syndrome (vEDS) is an inherited cardiovascular disease affecting the middle to large sized arteries, with an incidence rate of 1/5000. vEDS patients also show a significant phenotype of easily bruised skin, indicating aberrant wound healing and injury repair …
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Promoting endothelialisation to reduce vascular injury following coronary angioplasty and stent implantation
… that promote repair of the vasculature following injury are necessary to improve the clinical outcomes in patients undergoing angioplasty and stenting for coronary artery disease. I sought to establish a new cellular model to study the coronary endothelium in patients with acute myocardial …
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Development and validation of an in vitro human model of drug-induced vascular injury
… drug reactions (ADRs). Among these, cardiovascular (CV) ADRs occur with a high incidence. Affecting the heart, blood vessels and blood components, CV ADRs can lead to hypertension, heart failure, cardiac arrhythmias and thrombosis. The prompt identification of CV toxicity would reduce both …
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Deep Photoacoustic Imaging and Acoustic Cavitation Mapping in Shockwave Lithotripsy
… in small blood vessels may result in renal vascular injury. Current imaging modalities used in SWL (e.g., C-arm fluoroscopy and B-mode ultrasound) are not sensitive to vascular injuries. To better understand the mechanism of tissue injury and improve treatment safety and efficiency, it is …
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Penetrating cardio-thoracic injuries at a district level hospital in Cape Town South Africa : A retrospective case audit
… pulse, presence of a precordial stab wound, vascular injury, base deficit (BD) and lactate. A logistic regression analysis was performed to investigate the relationship between the selected variables and the 48-hour mortality. The relationship between fluid, BD and lactate was compared using …
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Sulfatides mediate Disabled-2 membrane localization and stability during platelet aggregation
… platelet aggregation. During the repair of vascular injury, clotting usually occurs when platelets adhere to each other at the site of vascular injury in order to stop bleeding.2 Distinct protein receptors and adhesive ligands together with the blood flow conditions govern this process. One …
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Charakterisierung des proinflammatorischen Phänotyps neointimaler glatter Gefäßmuskelzellen nach Gefäßverletzung
… recruitment is cruicial for the response to vascular injury in spontaneous and accelerated atherosclerosis. Whereas the mechanisms of leukocytes to endothelium or matrix-bound platelets have been characterized, less is known about the proadhesive role of smooth muscle cells that get exposed …
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CT angiogram findings in patients presenting with mechanical strangulation and near hanging injuries
Background: Blunt cerebrovascular injury (BCVI) is relatively uncommon in near-hanging and strangulation injuries but may have devastating neurological outcome. In developed countries, CT angiography (CTA) of the head and neck is performed as a screening tool in the acute clinical setting. This …
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Role of ANLN in post ischaemic angiogenesis
… develop new therapeutic strategies for cardiovascular disease. One such gene identified in the Caporali lab is Anillin (ANLN) an F-actin binding protein with functions in cytokinesis, asymmetric cell division and potential roles in migration and proliferation in multiple cell types. We …
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A genome-wide, single-cell analysis of vascular smooth muscle cell plasticity
Vascular smooth muscle cells (VSMCs) possess a remarkable capacity to change phenotype in response to injury or inflammation. In healthy arteries, VSMCs exist in a contractile state, but upon vascular inflammation or injury, they can switch into an activated state, in which they downregulate the …
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Endovascular Optical Coherence Tomography Imaging in Cerebrovascular Disease
… focused on the diagnosis and treatment of vascular diseases of the central nervous system. The appeal of treating vascular diseases through minimally invasive techniques without the need for open surgery has led to continued technological innovation and device development. Endovascular …
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A platelet-mediated paradigm for the targeted delivery of microencapsulated, clot-augmenting biotherapeutics
… of a clot-augmenting therapeutic to a site of vascular injury. In this system, platelets target microencapsulated drugs through their natural aggregation behavior in the clot formation process and then deliver the drug by physically rupturing the microcapsule through contractile forces exerted …
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Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease
Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation and the phenotypic changes within individual VSMCs, which underlie vascular disease remain unresolved. In particular, it is not known if all VSMCs …
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Fine Particulate Matter, Neuropathologies, & Dementia
… and short-term PM2.5 exposure and biomarkers of vascular injury (E-selectin, vascular cell adhesion molecule-1 (VCAM-1)) in the cerebrospinal fluid (CSF). This question is important to investigate because of the growing evidence of the role of cerebrovascular disease in dementia as well as …
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Applications of blood biomarkers of traumatic brain injury across the severity spectrum---a focus on pathophysiological mechanisms
INTRODUCTION. Traumatic Brain Injury (TBI) is a global health concern. Spanning mild cognitive disturbances to unsurvivable trauma, the clinical challenges of TBI range from acute life-saving predicaments to the management of chronic cognitive impairment. While the primary insult leading to injury …
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Identification of a vascular smooth muscle cell transition associated with fibrous cap formation and induced by thrombin receptor activation
Introduction: Vascular smooth muscle cells (VSMCs) accumulate in atherosclerotic plaques and display phenotypic plasticity that influences both plaque growth and stability. The fibrous cap, a stabilising feature of plaques, contains an abundance of VSMC-derived cells. However, the cellular …
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Penetrating injuries of the thoracic aorta and its branches
… the First World War no survivors with thoracic vascular injury were recorded among soldiers treated with penetrating injuries to the chest as recorded by Makins. The first record of successful repair of a penetrating thoracic aortic injury was in 1922 by Dshanelidze in Russia. Similar to Makins' …
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Roles of coagulation factor XIII in the functions of blood platelets
Haemostasis is initiated following blood vessel injury to preclude loss of blood. It involves concerted actions of blood platelets and soluble coagulation factors in forming blood clots at sites of vascular injury. Platelets are recruited from flowing blood and become activated to fulfil their …
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