Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"vascular inflammation"”.
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Crosstalk between CX3CL1 and the Cytoskeleton during Vascular Inflammation
… contributes to two critical aspects of vascular inflammation. Initially in Chapter 2, I focus specifically on endothelial cells and the unique transmembrane chemokine, CX3CL1, which is strongly implicated in the recruitment of leukocytes to the vascular intima and the progression of …
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Investigating the impact of flavonoid metabolites on endothelial function and vascular inflammation
… has been associated with reduced cardiovascular disease risk, however, many in vitro studies have demonstrated effects using supraphysiological concentrations of flavonoids, overlooking the potential bioactivity of flavonoid metabolites and additive effects in combination. This thesis …
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The A2A adenosine receptor: its role in suppressing vascular inflammation and its regulation by phosphorylation
Endothelial inflammation leading to vascular dysfunction is a major contributor to the development of atherosclerosis. The release of adenosine at sites of inflammation represents an endogenous mechanism for limiting excessive inflammation and tissue damage. The majority of the anti-inflammatory …
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ESTROGEN, VASCULAR INFLAMMATION, AND INTERLEUKIN-17 IN RELATION TO ATHEROSCLEROSIS IN A FEMALE NONHUMAN PRIMATE MODEL
The role of T helper 17 (Th17) cells and interleukin-17A (IL-17A), a signature pro-inflammatory cytokine for Th17, in atherosclerosis is unknown. Postmenopausal estrogen therapy (ET) mediates atheroprotection in part through anti-inflammatory effects; however, the effects of ET on Th17 cells and …
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MITOCHONDRIA FACILITATE VASCULAR INFLAMMATION: THE ROLE OF CANONICAL INFLAMMATORY SIGNALING IN THE REGULATION OF MITOCHONDRIAL MORPHOLOGY
Vascular inflammation is an underlying cause to numerous diseases and is characterized by classical NF-κB activation and downstream physiological responses including inflammatory gene induction and immune cell recruitment. Although inflammatory based diseases are associated with mitochondrial …
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Mechanism of local IL-6 production and its role in accelerating vascular inflammation leading to aortic diseases
Vascular inflammation plays a significant role in aortic diseases and involves enhanced recruitment and local activation of circulating monocytes along with cytokine production, but the mechanisms responsible for these processes are unclear. The cytokine interleukin-6 (IL-6) is highly induced in …
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Molecularly Targeted Nanoparticles for Modulation of Inflammatory Mediators in Atherosclerosis
… studies to play a crucial role in mediating both inflammation and thrombosis in atherosclerosis. The cellular effects of thrombin in promoting atherosclerosis involve the activation of signaling pathways that result in the secretion of a host of various chemokines, cytokines, cell adhesion …
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Obesity as a Risk Factor for Preeclampsia: Role of Inflammation and the Innate Immune System
… to preeclampsia by mechanisms involving inflammation and the innate immune system. First, we used immunohistochemical studies to identify neutrophil infiltration, NF-κB activation and COX-2 expression in vascular tissue of obese women. We then demonstrated similar neutrophil infiltration …
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Investigation of the mechanisms underlying the development of atherosclerosis.
… by aging males are associated with cardiovascular disease. Clinical trials have shown that testosterone replacement therapy (TRT) can improve symptoms of cardiovascular disease and reduce the inflammatory burden, evident in the early stages of atherosclerosis. Thus, a potential role of …
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Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha
Vascular complications of diabetes account for the majority of morbidity and mortality among diabetic patients. Large clinical trials have identified hyperglycemia as a risk factor in the development of diabetic vascular complications. The effects of hyperglycemia on the vessel wall are not fully …
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Unraveling The Effects of Aerobic Exercise and Erk5 Signaling In The Solid Tumor Microenvironment Using Murine Models
… models and that the ERK5 axis regulates tumor vascular permeability. By utilizing a novel mouse model, we demonstrated that knockout of endothelial cell specific ERK5 causes vascular inflammation and eventual death of mice. We then explored the role of exercise in vascular inflammation and …
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Mechanisms of Cerebral Autoregulation in Traumatic Brain Injury
… techniques, I show that proteins relating to vascular inflammation are associated with deranged PRx and intracranial pressure following brain injury. Notably, proteins of the complement cascade emerged as key candidates (Chapter 5). As a natural next step of investigation, complement …
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Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… Atherosclerosis is a major cause of cardiovascular diseases, driven by vascular inflammation that begins with endothelial dysfunction. The endothelium, which lines blood vessels, plays a critical role in regulating vascular tone and immune cell interactions. In response to inflammatory …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… tamoxifen in both adventitial fibroblasts and in vascular smooth muscle cells (VSMCs). Interestingly, I observed that deletion of RelA from aortic VSMCs and fibroblasts, using Col1a2-CreERT mice containing RelA-flox alleles, protects from Ang II mediated AAA formation. Furthermore, aortic-RelA …
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Atherosclerotic inflammation imaging using somatostatin receptor-2 positron emission tomography
… pathogenic mechanisms relating clinical cardiovascular disease (CVD) risk factors to atherosclerotic plaque progression and rupture. Imaging vascular inflammation affords a valuable marker of atherosclerotic disease activity to reveal important mechanistic insights for CVD research, to quantify …
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Does military combat-related traumatic injury increase cardiovascular disease risk?
… (CRTI) is associated with an increased cardiovascular (CV) disease (CVD) risk. However, data from a contemporary military population with CRTI is lacking. Hypotheses: The main hypotheses addressed in this thesis are: 1. Military servicemen who have had suffered severe CRTI with limb …
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Endothelial injury and repair in vasculitis of the young
… spectrum of disorders which are characterised by vascular inflammation. Endothelial injury can occur as a consequence of inappropriate inflammation and is central to the pathogenesis of these varied diseases. This thesis documents the development of assays for detection of novel biomarkers of …
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The Effect of Chronic Hypertension on Neuropathology in the TGSWDI Mouse Model of Alzheimer's Disease
<p>Numerous epidemiological studies link vascular disorders, such as hypertension, diabetes and stroke, with Alzheimer's disease. Hypertension, specifically, is an important modifiable risk factor for late onset Alzheimer's disease. Despite the abundance of clinical data connecting these …
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Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… to examine the hypothesis that the degree of vascular inflammation correlates with the expression of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In …
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Cerebral Amyloid Angiopathy and Transition Metals in Alzheimer's Disease
… disease brain and specifically whether microvascular bleeding is a major contributor to Alzheimer's disease-related iron overload. Cerebral amyloid angiopathy (CAA) is a vascular manifestation of Alzheimer's disease present to some degree in up to 95% of Alzheimer's disease patients. This …
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