Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"vascular endothelial growth factor-A (VEGF-A)"”.
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Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes
… sensing pathways including the Hypoxia Inducible Factor (HIF)-Vascular Endothelial Growth Factor-A (VEGF-A) and HIF-Erythropoietin (EPO) pathways. RNA sequencing (RNA-Seq) data from our previously published experiments revealed a potentially novel VEGF-A splice variant with excision of the VEGF …
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A Kinetic Study of Anti-VEGF-A Polyclonal Antibodies and Anti-VEGF-A ssDNA Aptamers
… aptamers perform similarly to antibodies, anti-VEGF-A polyclonal antibody and anti-VEGF-A ssDNA aptamer were evaluated against vascular endothelial growth factor A (VEGF-A) using Surface Plasmon Resonance (SPR). It was hypothesized that the anti-VEGF-A aptamer had the same, if not better, …
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Effects of ionizing radiation on normal and tumor-associated lymphatic vessels
… study the radiation dose response of lymphatic endothelial cells. Putative lymphatic endothelial cell mitogens and antiproliferative agents, including vascular endothelial growth factor-A (VEGF-A), VEGF-C and AZD2171, a tyrosine kinase inhibitor of the VEGF receptors, were tested as radiation …
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Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease
… and promoted the expression of pro-angiogenic factors including leptin and vascular endothelial growth factor-A (VEGF-A). To investigate the potential involvement of anti-angiogenic factors in mediating the capillary remodelling response in obesity, I investigated the role of forkhead box O …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… is a key regulator of local blood distribution, vascular resistance and overall blood pressure (BP). Arterioles and capillaries are two important components of the microcirculation, which can undergo remodeling such as arteriogenesis, angiogenesis, or capillary rarefaction. Vascular remodeling …
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G-Protein-Coupled Estrogen Receptor-1 (GPER): A Potential Target For Xenoestrogens During Vertebrate Embryogenesis.
… data, we hypothesized that the developing cardiovascular system was the primary target organ for G-1-induced toxicity. Using quantitative in vivo imaging assays and transgenic zebrafish (fli1:egfp), we then demonstrated that G-1 exposure resulted in impaired cardiac morphology and performance as …
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Transcription Factor Engineering: Tools and Applications
Transcription factors play a vital role in the biology of every organism. By controlling gene expression they regulate growth, development, metabolism, reproduction, signaling, and response to the environment. They have also provided the basis for many useful tools in molecular biology. The …
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Analysis of the expression and effects of vascular endothelial growth factor family of molecules on Fragile X Syndrome abnormalities in a mouse model
… have all failed, attributing to various factors such as a need for optimized dosage, developmental time for intervention, better metrics for human studies, and most prominently complexity of the mGluR pathway (Scharf et al., 2015). With this ubiquitous failure of mGluR inhibitors, new …
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Expression of Vascular Endothelial Growth Factor-A and its Receptors in Uteroplacental Tissues of the Normotensive and Hypertensive Pregnant Rat
… leading to preeclampsia and fetal intrauterine growth retardation. Many studies have shown that vascular endothelial growth factor A (VEGF-A) is a potent angiogenic factor, that is, it is responsible for the formation of new blood vessels from existing vessels. VEGF-A has been shown to be …
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Evaluation of suboptimal health status and prospective levels of oxidative stress biomarkers and angiogenic growth mediators with placental anatomy and pathology in normotensive and preeclamptic births
… oxidative stress (OS) biomarkers and angiogenic growth mediators (AGMs) with placental anatomy and pathology in normotensive and preeclamptic births in a Ghanaian Population. This longitudinal nested case-control study was based on the Ghanaian Suboptimal Health Status Cohort Study (GHOACS) that …
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Hypoxiemarker im equinen Endometrium im klinisch-pathomorphologischen Kontext
… der Antikörper gegen hypo-xia-inducible factor 1α (HIF-1α), Glucosetransporter 1 (GLUT1), vascular endothelial growth factor A (VEGF A) und vascular endothelial growth factor receptor 2 (VEGF-R2) hinsichtlich der Expression dieser Hypoxiemarker immunhistologisch untersucht. Für …
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Micrornas That Affect Breast Cancer Growth, Metastasis And Estrogen-Independent Growth
… cell proliferation and anchorage-independent growth as well as cell invasion. Furthermore, mir-205 was shown to suppress lung metastasis in a mouse model. Finally, western blot combined with the luciferase reporter assays demonstrated that ErbB3 and vascular endothelial growth factor A …